[PDF] Top 20 'Cell or Not to Cell' that is the question : for intervertebral disc regeneration?
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'Cell or Not to Cell' that is the question : for intervertebral disc regeneration?
... of disc degeneration was furthered by the observation that spontaneous IVD degeneration occurred in a knockout mouse model where the natural inhibitor of IL-1 (IL-1Ra) was removed [47], which is further supported ... See full document
10
Effect of coculturing canine notochordal, nucleus pulposus and mesenchymal stromal cells for intervertebral disc regeneration
... in disc development, have been suggested to stimulate the regenerative capacity of the resident cells of the degenerated disc (NPCs), as well as the add- itionally introduced exogenous MSCs ... See full document
12
Hyaluronan: its potential application in intervertebral disc regeneration
... vitro cell culture study showed that the seeded human articular chondrocytes were able to proliferate and form cartilage specific extracellular matrix in the ...constructs. Regeneration of bovine articular ... See full document
10
To test or not: occurrence of sickle cell trait and assessment of the awareness toward its screening among patients attending Magale Health Center IV, Namisindwa District, Eastern Uganda
... Materials and methods: We conducted a cross sectional study, in which we consecutively enrolled participants aged ≥18 years at Magale Health Center IV. Four milliliters of EDTA blood were collected by venipuncture and ... See full document
7
Adipose-Derived Stromal Cells Protect Intervertebral Disc Cells in Compression: Implications for Stem Cell Regenerative Disc Therapy
... the question re- mains open on the impact of ADSCs’ upon NP cells in abnormal compressive load, which might be a similar scenario with the actual IVD biomechanical environ- ...stem cell therapy for inter- ... See full document
11
Current strategies for treatment of intervertebral disc degeneration: substitution and regeneration possibilities
... Background: Intervertebral disc degeneration has an annual worldwide socioeconomic impact masked as low back pain of over 70 billion ...prolonged intervertebral disc mistreatment triggers a ... See full document
19
Notochordal cell disappearance and modes of apoptotic cell death in a rat tail static compression induced disc degeneration model
... second question concerns with the causative roles of notochordal cell disappearance and increased apoptosis of non-notochordal cells in intervertebral disc degener- ...that cell death ... See full document
11
Cell based therapies for intervertebral disc and cartilage regeneration Current concepts, parallels, and perspectives
... cartilage regeneration in chondron coculture with allogeneic MSCs amenable to a single stage surgery which is currently in Phase 1/2 evaluation in the IMPACT ...primary cell based ventures (Figure 2B) in ... See full document
41
Identification and characterization of human nucleus pulposus cell specific serotypes of adeno associated virus for gene therapeutic approaches of intervertebral disc disorders
... positive cell detection (Table 2 and ...during cell division [34, 35, ...prolonged regeneration time (weeks to ...NP cell viability, MTT assays were per- ...the cell viabilities by 9 % ... See full document
12
Stem cell horizons in intervertebral disc degeneration
... NP cell type is not well charac- terized, but NP cells identifi ed by their production of the req- uisite ECM components can suffi ...IVD regeneration with stem cell therapy could be a viable treatment ... See full document
10
TGF-β1 reduces the oxidative stress-induced autophagy and apoptosis in rat annulus fibrosus cells through the ERK signaling pathway
... Oxidative stress can activate the mitogen-activated pro- tein kinases (MAPKs) pathway [27], including ERK1/2, JNK, and p38, to regulate cell autophagy and apoptosis. However, the main pathway may be different for ... See full document
13
Measuring Dimensions of Lumbar Intervertebral Discs in Normal Subjects
... anterior disc height, middle disc height, posterior disc height and horizontal length from verte- bra L1 to vertebra S1(including five lumbar interverte- bral spaces) on 178 outpatients who had low ... See full document
6
JAG2/Notch2 inhibits intervertebral disc degeneration by modulating cell proliferation, apoptosis, and extracellular matrix
... the DISC was initiated by the activation of RIP1 trigger apoptosis following TNF-α induction ...In cell lines sensitive to TNF-α-induced apoptosis, it has been shown that two types of signaling complexes ... See full document
14
Degeneration of the intervertebral disc
... between disc degeneration and gene polymorphisms of matrix ...between disc degeneration and polymorphisms of the major collagens in the disc, col- lagen types I and II [103], mutations of two ... See full document
11
Intervertebral disc disease in Dachshunds radiographically screened for intervertebral disc calcifications
... Our results support radiography as an effective screening tool for IDC and also by implication as a tool to diminish incidence of IDD in Dachshunds. Our results of a high positive association between IDC and IDD are in ... See full document
7
Exosomes as potential alternatives to stem cell therapy for intervertebral disc degeneration: in-vitro study on exosomes in interaction of nucleus pulposus cells and bone marrow mesenchymal stem cells
... Cell–cell communication is based on paracrine, connex- ons or cell–cell direct contact. In recent years, researchers turned attention to a special paracrine mechanism: that of exosomes. ... See full document
11
Over-production of therapeutic growth factors for articular cartilage regeneration by protein production platforms and protein packaging cell lines
... packaging cell lines such as GP- 293 cells may be used as “cellular factories” for large-scale production of therapeutic proteins and pro-anabolic growth factors, particularly in the context of cartilage ...live ... See full document
20
INTERVERTEBRAL DISC PATHOLOGY AND AYURVEDA .......
... The disc can prolapse or protrude as a result of the pressure of the nucleus and the lack of ability of the annulus fibro- sus to sustain ...of disc height, which causes all ligaments to be placed on ... See full document
10
Intervertebral disc and vertebral endplate subchondral changes associated with Modic 1 changes of the lumbar spine: a cross sectional study
... bral disc (IVD) and vertebral endplate subchondral bone (VESB) associated with Modic 1 changes, were first described and classified by Modic et ...degenerative disc disease (DDD) also occur, and include ... See full document
7
Original Article Identification of notochordal cell-specific molecular markers in mouse intervertebral disc
... For light microscopy, tissues from 1-week- and 22-month-old mice were fixed in 4% parafor- maldehyde (PFA)/phosphate buffered saline (PBS) (pH 7.4) for 24-48 h at 4°C followed by decalcification in fresh 10% ... See full document
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