Top PDF Cell-Selective Chemoproteomics for Biological Discovery
Cell-Selective Chemoproteomics for Biological Discovery
... in cell-specific translatomics and proteomics—fueled in part by the development of bioorthogonal chemistries, more sensitive mass spectrometers and more advanced mining ...
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Cell-selective proteomics for biological discovery
... Notably, all amino acids and enrichment media needed for BONCAT experiments are commercially available. Stochastic Orthogonal Recoding of Translation (SORT) Chin and coworkers have developed a residue-specific ...
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Biological effects of selective COX-2 inhibitor NS398 on human glioblastoma cell lines
... GBM cell lines treated with NS398 or with drug vehicle DMSO (CNTR), immediately after the scratch at the initial time (T0) and after 8 h and 24 ...GBM cell lines after incubation with EV derived from ...
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Chemoproteomics reveals Toll-like receptor fatty acylation
... previous discovery of the critical role of palmitoylation of IFITMs in the innate antiviral immune response [7,14,15], we sought to determine whether any additional IFN-induced proteins are regu- lated by ...these ...
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Discovery of selective, antimetastatic and anti cancer stem cell metallohelices via post assembly modification
... Introduction Lehn envisaged in the original report 1 that helicates 2–4 – self- assembling multimetallic coordination compounds – may nd uses in biochemistry. Indeed, while their underlying chemistry is very different to ...
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Discovery of orbital selective Cooper pairing in FeSe
... 20 Figure 1 Bogoliubov Quasiparticle Interference Model for FeSe (A) Top view of FeSe crystal structure. Dashed lines represent the 1-Fe unit cell, and the actual unit cell is shown using solid lines. The ...
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The discovery of I-BRD9, a selective cell active chemical probe for bromodomain containing protein 9 inhibition
... the biological role and therapeutic potential of this reader ...BRD9 selective chemical probes described in the literature to ...the discovery of I-BRD9, the first selective cellular chemical ...
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The discovery of I-BRD9, a selective cell active chemical probe for bromodomain containing protein 9 inhibition
... the biological role and therapeutic potential of this reader ...BRD9 selective chemical probes described in the literature to ...the discovery of I-BRD9, the fi rst selective cellular chemical ...
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Knowledge discovery for stochastic models of biological systems
... a cell cycle model, while the approach to identify and estimate the parameter effects on a desired model output has been tested on a predator- prey model to evaluate the relationship among parameters and ...
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Selective Green Device Discovery for Device-to-Device Communication
... Copyright © 2017 Universitas Ahmad Dahlan. All rights reserved. 1. Introduction Due to the explosion of the mobile service and user demand [1], the mobile network is expected to be highly congested in the near future ...
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MicroRNA in Oral Squamous Cell Carcinoma and Oral Potentially Malignant Lesions: from biological discovery to clinical utility.
... 5. Discussion Histological diagnosis cannot evaluate the risk of malignant transformation. Thus, miRNA has revealed to be good biomarkers for the management of these lesions. It seems that miRNAs can regulate important ...
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Innovation of System Biological Approach in Computational Drug Discovery
... to cell biology, however, seem more likely to contribute to the large-scale compound and gene function analyses desired by industry and required as a basis for modeling ...
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Stem cell biology and drug discovery
... starting cell population, but a population of partially reprogrammed intermediate cells that appeared 1 to 2 weeks after virus ...real biological process: cell ...
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Discovery of functionally selective C5aR2 ligands: novel modulators of C5a signalling.
... the discovery of two functionally selective ligands (P32, P59) for C5aR2, which are partial agonists (when compared to C5a) for β-arrestin 2 ...functionally selective ligands for ...the ...
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Integration of Genomic Data Enables Selective Discovery of Breast Cancer Drivers
... drivers can impact more patients ( Figure 1 A). However, to date, this possibility has been limited by the difficultly of distinguishing passengers and drivers in the majority of SCNAs. Here, we have presented a major ...
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Discovery of biological networks from diverse functional genomic data
... these biological processes has not yet been well characterized, evidence in the literature supports these predicted ...complex, cell cycle-related proteins, and MCM pro- ...exhibit cell cycle arrest, ...
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Advancing Biological Understanding and Therapeutics Discovery with Small-Molecule Probes
... 178 cell-based screens were available (Wawer et ...induced cell morphology and gene expression patterns not seen within the 12,000 bioactives, likely hinting at novel mechanisms of ...
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Chemical Genomics: A Systematic Approach in Biological Research and Drug Discovery
... mRNAs are prepared from the treated and untreated cell or organism, and then used to produce fluorescence- labeled cDNAs to hybridize DNA microarrays and generate gene expression profiles. By comparing the ...
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Induced cancer stem-like cells as a model for biological screening and discovery of agents targeting phenotypic traits of cancer stem cell
... initiating cell population therefore resulting in complete cure of the ...stem cell (iPSC) technology to reprogram and partially differentiate human mammary epithelial MCF-10A ...by cell viability, ...
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Induced cancer stem-like cells as a model for biological screening and discovery of agents targeting phenotypic traits of cancer stem cell
... initiating cell population therefore resulting in complete cure of the ...stem cell (iPSC) technology to reprogram and partially differentiate human mammary epithelial MCF-10A ...by cell viability, ...
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