[PDF] Top 20 Cell and small animal models for phenotypic drug discovery
Has 10000 "Cell and small animal models for phenotypic drug discovery" found on our website. Below are the top 20 most common "Cell and small animal models for phenotypic drug discovery".
Cell and small animal models for phenotypic drug discovery
... quantify cell-specific ...of cell behavior, such as migration. The analysis of cell migration is not always straightforward and can generate ...during cell extension (Figure ...entire ... See full document
11
Inaugural Charles River World Congress on Animal Models in Drug Discovery and Development
... in cell-to-cell propagation of pathology, and can adopt conformations with cytotoxic ...B cell memory. We hypothesized that selected B cell clones triggered by neo-epitopes of pathological ... See full document
7
Tumor xenograft animal models for esophageal squamous cell carcinoma
... and phenotypic properties as the donor tumors. Since the stromal and cell components of the patient-derived tumor xenografts are maintained as in the donor tumors, the use of this model can exclude the ... See full document
8
Stem cell biology and drug discovery
... stem cell biology as a route to novel therapeutic drugs arose from the convergence of three separate lines of ...druglike small molecules that inhibit hedgehog signaling and are effective in various cancer ... See full document
11
3 Dimensional cell culture: the missing link in drug discovery
... a drug on the ...higher drug resistance, but that it is a combi- nation of the specific drug and the cellular environment that influence the cells’ reaction ...tumour models as relevant for ... See full document
10
Role of G-Protein Coupled Receptors in Cancer Research and Drug Discovery
... therapeutic drug target ...therapeutic drug target for cancer ...for drug discovery for treatment and control of ...and drug discovery as a therapeutic ...squamous cell ... See full document
5
Investigating long noncoding RNAs using animal models
... human cell line, the binding of lncRNAs to the protein complex Mediator promotes permissive chromatin states necessary for gene expression, and mutations in Mediator that result in intellectual disability have ... See full document
10
PHARMACODYNAMIC AND PHARMACOKINETIC DRUG INTERACTION OF GLIMEPIRIDE AND IRBESARTAN IN ANIMAL MODELS
... of drug interactions and the results can be extrapolated to humans, which will provide information regarding rational usage of this combination in a clinical ... See full document
5
Revisiting the Stress Concept: Implications for Affective Disorders
... Steroid hormones were recognized in the 1960s as having major action via epigenetic regulation of gene expression. Upon their cloning, the corticosteroid hormone receptors GR and MR were classified as ligand-dependent ... See full document
10
Synthetic biology for pharmaceutical drug discovery
... in drug synthesis culminated with the bioproduction of artemisinin by microorganisms, a tour de force in protein and metabolic ...as cell-based screening platforms for both target-based and ... See full document
18
Translational challenges of animal models in Chagas disease drug development: a review
... of animal models designed for Chagas disease drug ...and models designed for translation to human disease. Existing animal models address both disease pathology and treatment ... See full document
17
Toxins and drug discovery
... While venoms featured in several systems of traditional healing, the modern translation of toxins into medicines began in the 1940s with the introduction of tubocurarine into anaesthetic practice as a selectively acting ... See full document
8
Finding the needle in the haystack: why high throughput screening is good for your health
... of drug development targets (or target path- ways), in addition to those already mentioned in the previ- ous section, that may have particular ...various cell-cycle regulation targets (in particular, the ... See full document
7
Drug discovery and development for neglected diseases: the DND<em>i</em> model
... DNDi is a needs-driven organization (ie, the needs of patients suffering from NTDs are the driving force for all drug discovery and development programs). DNDi, through consultation with expert committees ... See full document
7
Drug discovery in jeopardy
... of drug companies. Reduced pro- ductivity in the drug industry is caused mainly by corporate policies that discourage ...for drug discovery are ... See full document
7
3 D Printing a Revolutionary Approach in Medicinal Science- Review
... complex drug- release profiles. Complex drug manufacturing processes could also be standardized through the use of 3D printing to make them simpler and more ... See full document
11
DNA Tumor Viruses and Their Contributions to Molecular Biology
... Among these technical advances are developments in high-resolution structural biology coupled with incredible increases in computer power, which will continue to enhance our understanding of macromolecular structures and ... See full document
10
PHARMACODYNAMIC DRUG INTERACTIONS OF METFORMIN AND LACIDIPINE IN ANIMAL MODELS
... Oral hypoglycemic agents are used in the treatment of Type-2 diabetes, among which a biguanide derivative known to be Metformin is widely prescribed and preferred in therapy because of its multiple beneficiary effects in ... See full document
6
Immunity against fungi
... The discovery of β-glucan–induced trained immunity and conserved sterilizing immunity-mediating epitopes lays the foundation for clinical trials to test vaccine protection against multiple fungal genera and ...in ... See full document
18
Animal models of ulcerative colitis and their application in drug research
... the drug candidate does not pertain to any specific pathway/process, chemically induced colitis mice may be a good ...spontaneous models, is the ease of controlling the chemical dosage, which affects the ... See full document
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