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[PDF] Top 20 Cell type specific epigenetic links to schizophrenia risk in the brain

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Cell type specific epigenetic links to schizophrenia risk in the brain

Cell type specific epigenetic links to schizophrenia risk in the brain

... other cell types compared to our cell-sorted ...between cell types, which we refer to as “differentially methylated positions (DMPs),” using a statistical method that allows us to explicitly take ... See full document

21

The effect of the neurogranin schizophrenia risk variant rs12807809 on brain structure and function

The effect of the neurogranin schizophrenia risk variant rs12807809 on brain structure and function

... a risk variant for schizophrenia in recent genome-wide association ...of risk variants may be more apparent at the level of brain, the aim of this investigation was to delineate whether NRGN ... See full document

9

The Effect of the Neurogranin Schizophrenia Risk Variant rs12807809 on Brain Structure and Function

The Effect of the Neurogranin Schizophrenia Risk Variant rs12807809 on Brain Structure and Function

... a risk variant for schizophrenia in recent genome-wide association ...of risk variants may be more apparent at the level of brain, the aim of this investigation was to delineate whether NRGN ... See full document

8

DNA methylation in schizophrenia: progress and challenges of epigenetic studies

DNA methylation in schizophrenia: progress and challenges of epigenetic studies

... that epigenetic status, especially DNA methylation, could also be altered by chance ...to epigenetic variation and might be an im- portant factor in complex diseases such as ...the brain has a ... See full document

13

Integrative network analysis of nineteen brain regions identifies molecular signatures and networks underlying selective regional vulnerability to Alzheimer’s disease

Integrative network analysis of nineteen brain regions identifies molecular signatures and networks underlying selective regional vulnerability to Alzheimer’s disease

... 19 brain regions by systematically comparing the number of gene signatures identified for six phenotypic traits encompassing the cognitive, NFT, and NP dimen- ... See full document

21

Time Shift Homotopic Connectivity in Mesial Temporal Lobe Epilepsy

Time Shift Homotopic Connectivity in Mesial Temporal Lobe Epilepsy

... This study combined time-shift functional connectivity analysis with VMHC analysis and observed ts-VMHC alteration in pa- tients with mTLE. The results showed the whole-brain pattern of aberrant interhemispheric ... See full document

7

Gender Specific Associations between CHGB Genetic Variants and Schizophrenia in a Korean Population

Gender Specific Associations between CHGB Genetic Variants and Schizophrenia in a Korean Population

... in schizophrenia, addi- tional statistical analyses in both sexes were performed to de- termine the effect of sex on disease ...with schizophrenia in male subjects (minimum ... See full document

7

Bayesian approach to the assessment of the population-specific risk of inhibitors in hemophilia A patients: a case study

Bayesian approach to the assessment of the population-specific risk of inhibitors in hemophilia A patients: a case study

... precision of the rates of inhibitor in PUPs in EUHASS for the specific molecule and for any factor VIII concentrate by 75% and 95% each, respectively. This is equal to the human process of any perceived ... See full document

15

Epigenetic profiling of human brain differential DNA methylation networks in schizophrenia

Epigenetic profiling of human brain differential DNA methylation networks in schizophrenia

... any specific methylated gene patterns identified for schizophrenia, there are significant associations between promoter CG islands (CGIs) hypermethylation ...and specific methy- lation levels of the ... See full document

12

Epigenetic sampling effects : nephrectomy modifies the clear cell renal cell cancer methylome

Epigenetic sampling effects : nephrectomy modifies the clear cell renal cell cancer methylome

... (Dynamic epigenetic changes to VHL occur with sunitinib in metastatic clear cell renal cancer, Stewart et al, Oncotarget), we demonstrated an epigenetic change in the VHL gene upon clear cell ... See full document

19

Epigenetic supersimilarity of monozygotic twin pairs

Epigenetic supersimilarity of monozygotic twin pairs

... of cell heterogeneity using an established method that uses methylation data to estimate the relative proportions of six white blood cell types ...without cell composition adjust- ment to assess ... See full document

20

Epigenetic features of testicular germ cell tumours in relation to epigenetic characteristics of foetal germ cells

Epigenetic features of testicular germ cell tumours in relation to epigenetic characteristics of foetal germ cells

... of epigenetic events takes place, leading to differentiation of the surrounding niche into male or female ...and epigenetic reprogramming involv- ing linker histone H1, H3K9ac, H3K9me2, H3K27me3, DAPI ... See full document

10

Visuospatial working memory in children and adolescents with 22q11.2 deletion syndrome; an fMRI study

Visuospatial working memory in children and adolescents with 22q11.2 deletion syndrome; an fMRI study

... whole brain coverage and was later used to register the fMRI datasets acquired from each individual in standard stereotactic ...whole brain: TE 40 ms, TR 2 s, in-plane resolution ... See full document

15

Global and gene-specific DNA methylation in adult type 2 diabetic individuals: a protocol for a systematic review

Global and gene-specific DNA methylation in adult type 2 diabetic individuals: a protocol for a systematic review

... an epigenetic mechanism that could be involved in the pathogenesis of type 2 diabetes mellitus ...Furthermore, epigenetic therapy has been suggested as a future possibility for T2DM ...treatment. ... See full document

5

Decreased serum levels of brain-derived neurotrophic factor in schizophrenic patients with deficit syndrome

Decreased serum levels of brain-derived neurotrophic factor in schizophrenic patients with deficit syndrome

... matched healthy individuals who were selected from the hos- pital staff were included in the study. Detailed psychiatric and medical family histories were received from the HC group, and none of them had a family history ... See full document

8

Evidence for genetic contribution to the increased risk of type 2 diabetes in schizophrenia

Evidence for genetic contribution to the increased risk of type 2 diabetes in schizophrenia

... In addition, there is evidence that the increased pre- valence of T2D in patients with SCZ is not purely medi- cation induced: Proteomic studies have revealed perturbed expression of genes involved in glucose meta- ... See full document

11

Cell type-specific response to high intracellular loading of polyacrylic acid-coated magnetic nanoparticles

Cell type-specific response to high intracellular loading of polyacrylic acid-coated magnetic nanoparticles

... Despite general similarities in NP uptake and their intracellular trafficking, there were also some differences between the three selected cell types. Morphologically, one of the main differences was the number of ... See full document

14

Schizophrenia and sleep disorders: links, risks, and management challenges

Schizophrenia and sleep disorders: links, risks, and management challenges

... of schizophrenia patients compared to the general ...of schizophrenia patients to engage in self- care behaviors such as exercising and maintaining a healthful ...at risk for OSA may go unnoticed, ... See full document

13

Recent quantitative genetic research on psychotic experiences: new approaches to old questions

Recent quantitative genetic research on psychotic experiences: new approaches to old questions

... on specific indi- vidual PEs, which brings greater clarity to what causes individual experiences such as paranoia, hallucinations, and negative symptoms individually, rather than assum- ing that PEs form part of a ... See full document

9

Brain Perivascular Spaces as Biomarkers of Vascular Risk: Results from the Northern Manhattan Study

Brain Perivascular Spaces as Biomarkers of Vascular Risk: Results from the Northern Manhattan Study

... the brain, it encounters first the lenticulostriate penetrating branches of the middle cerebral arteries supplying the subtantia innominata and the basal ganglia and, posteriorly, the vertebro- basilar system that ... See full document

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