[PDF] Top 20 Ceramide synthase 5 mediates lipid induced autophagy and hypertrophy in cardiomyocytes
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Ceramide synthase 5 mediates lipid induced autophagy and hypertrophy in cardiomyocytes
... LV hypertrophy (Table ...RV hypertrophy and increased cardiomyocyte cross-sectional area (Figure 1, B and ...CD, induced concentric cardiac hypertrophy and reduced cardiac function in the ... See full document
13
Endothelin 1 is an autocrine/paracrine factor in the mechanism of angiotensin II induced hypertrophy in cultured rat cardiomyocytes
... II-induced hypertrophy of neonatal rat cardiomyocytes by use of synthetic ET-1 receptor antagonist and antisense oligonucleotides to preproET-1 (ppET-1) ...in cardiomyocytes, but, to a lesser ... See full document
7
CDC20 regulates cardiac hypertrophy via targeting LC3-dependent autophagy
... in cardiomyocytes (Figure ...of autophagy (Figures 5 and ...inhibited autophagy to study its role in cardiomyocyte hypertrophy and demonstrated that LC3 is required for Ang ... See full document
13
Cardiac fibroblast–derived microRNA passenger strand enriched exosomes mediate cardiomyocyte hypertrophy
... overload–induced hypertrophy after aortic constriction and determined miR-21* levels (Figure ...cardiac hypertrophy compared with that in sham-operated mice (Figure ...in cardiomyocytes after ... See full document
12
Reactive Oxygen Species Related Noncoding RNAs as Regulators of Cardiovascular Diseases
... including cardiomyocytes, cardiac fibroblasts, vascular smooth muscle cells (VSMCs), endothelial cell (ECs), and resident and infiltrating leukocytes [44, ...II) induced cardiac hypertrophy ... See full document
8
G Protein-Coupled Estrogen Receptor 1 Inhibits Angiotensin II-Induced Cardiomyocyte Hypertrophy via the Regulation of PI3K-Akt-mTOR Signalling and Autophagy
... of autophagy [44]. Cardiac autophagy plays an important role in maintaining cell homeostasis, which at the basal level protects cells against various ...excessive autophagy can cause autophagic cell ... See full document
12
Mouse Sirt3 promotes autophagy in AngII-induced myocardial hypertrophy through the deacetylation of FoxO1
... program. Autophagy serves as a dynamic recycling mechanism and provides energy or metabolic ...whether autophagy is a protective or detrimental ...myocardial hypertrophy with chronic angiotensin II ... See full document
12
Effects of Hypoxia on Oxidative Stress, Autophagy and Apoptosis in Cardiomyocytes
... Chemistry Autophagy acts as a survival mechanism under stress conditions, maintaining the cellular integrity by regenerating metabolic precursors and clearing subcellular debris ...During autophagy, ... See full document
14
Macrophage-derived MCPIP1 mediates silica-induced pulmonary fibrosis via autophagy
... MCPIP1 plays a role in regulating autophagy and sub- sequently promoting cell apoptosis [67]. In this study, we observed that MCPIP1 was critical for autophagy in our model of silica exposure. Moreover, ... See full document
17
Carcinoembryonic Antigen Expression and Resistance to Radiation-and 5-Fluorouracil-Induced Apoptosis and Autophagy
... The human colorectal carcinoma cell lines SW742, HT29/219 and the Chinese hamster ovary (CHO) cell line were obtained from the National Cell Bank of Iran (NCBI, Pasteur Institute, Tehran). All cell lines were cultured in ... See full document
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Lipid induced insulin resistance mediated by the proinflammatory receptor TLR4 requires saturated fatty acid–induced ceramide biosynthesis in mice
... Infusion of lard oil, but not soy oil, induces inflammation and insulin resis- tance in rats. Experimental infusion of triglyceride-heparin emul- sions into the bloodstream of rodents and humans has become a common ... See full document
14
Differential Regulation of Ceramide Synthase Components LAC1 and LAG1 in Saccharomyces cerevisiae
... of ceramide synthesis by multiple mechanisms in ...the ceramide synthase reaction may be withdrawn from the path- way by either enzymatic breakdown (54) or transport out of the cell by the recently ... See full document
13
Nitric oxide synthase mediates the apelin induced improvement of myocardial postischemic metabolic and functional recovery
... NO has previously been implicated in endothelium- dependent vasorelaxation triggered by apelin [34,35]. This effect is reduced in the presence of L-NAME, indi- cating that the peptide exerts vasodilation via activation ... See full document
7
Ceramide/Long-Chain Base Phosphate Rheostat in Saccharomyces cerevisiae: Regulation of Ceramide Synthesis by Elo3p and Cka2p
... vitro ceramide synthase activity ...of ceramide synthase and that CKA2 mutants accumulate ceramide synthase substrates define a new impor- tant cellular role for CK2 kinase in ... See full document
11
-induced apoptosis in neonatal cardiomyocytes
... on cardiomyocytes before H 2 - O 2 ...cond, cardiomyocytes were treated with 100 μM H 2 O 2 for another 24 ...ment, cardiomyocytes were either transfected with IGF1R_siRNA to down-regu- late IGF1R, ... See full document
6
Cell-specific ablation of Hsp47 defines the collagen-producing cells in the injured heart
... cold sterile 1× Hanks’ Balanced Salt Solution (HBSS, Gibco, 14025092) and treated as described previously (68). Briefly, tissues were thoroughly minced with sterile fine scissors and digested in 2 ml DMEM containing a ... See full document
19
Insulin receptor Thr1160 phosphorylation mediates lipid induced hepatic insulin resistance
... In vitro insulin receptor kinase assays. Recombinant human IRK domain (INSR [residues 978–1283]; WT, T1160A, and T1160E) was expressed in Sf9 insect cells and purified by ion-exchange chroma- tography (Source Q; GE ... See full document
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Stress Induced Changes in the Lipid Microenvironment of β (1,3) d Glucan Synthase Cause Clinically Important Echinocandin Resistance in Aspergillus fumigatus
... Alternative mechanism of echinocandin resistance. Echinocandin resistance in Aspergillus is a relatively new phenomenon that involves modulation of the drug-target interaction mediated via two separate mechanisms of ... See full document
15
Nitric oxide and the control of coronary vascular tone
... view of the apparent differences in ACh response by species and vascular bed. Amezcua et al (1989) in the isolated rabbit heart found no effect of L-arginine (lOOpM) on the ACh response (while demonstrating marked ... See full document
153
Lipid A’s Structure Mediates Neisseria gonorrhoeae Fitness during Experimental Infection of Mice and Men
... gonorrhoeae lipid A influences gonococcal inflammatory signaling and susceptibility to innate host defenses in in vitro ...gonococcal lipid A in com- petitive infections in female mice and in male ... See full document
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