[PDF] Top 20 Chemical scale investigations of ligand gated ion channels using unnatural amino acids
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Chemical scale investigations of ligand gated ion channels using unnatural amino acids
... 5-HT 3 R and nAChR in which a series of progressively fluorinated tryptophans is used to identify the cation- binding site of the 5-HT 3 R and to compare and contrast ligand- recognition properties between the two ... See full document
14
Structure-function Studies of Nicotinic Acetylcholine Receptors Using Unnatural Amino Acids
... of ligand-gated ion channels, a global conformational change, initiated by agonist binding, results in channel opening and the passage of ions across the cell ...the ligand binding ... See full document
157
Chemical-Scale Studies of Ligand-Gated Ion Channels
... of ion channels, which are large, multi-subunit proteins, is essential to understanding the biological function of these neuroreceptors and their interactions with ...different ion channels ... See full document
203
Chemical-Scale Studies of G Protein-Coupled Receptors and Ligand-Gated Ion Channels
... in ligand binding nor conformational changes, is generally tolerant of mutations and does not show any obvious trends in the mutagenesis ...Conventional amino acids are modestly to substantially ... See full document
209
Biophysical Studies of Ligand-gated Ion Channels
... Unnatural Amino Acid Mutagenesis Since being first reported in 1989, unnatural amino acid (UAA) mutagenesis has proven to be a powerful tool for engineering novel functionalities into proteins ... See full document
121
A chemical-scale study on the ligand-binding site of a serotonin-gated ion channel
... an unnatural amino acid using this ...desired unnatural amino acid but no other tRNAs in the ...with unnatural amino ...novel amino acids have been ... See full document
145
Non-Canonical Amino Acids As Biochemical Probes of Ligand-Gated Ion Channel Structure and Function
... the ligand-gated ion channels Communication among cells in the nervous systems of higher organisms is conducted by electrochemical impulses called action potentials (Figure ...the ... See full document
146
Investigating Structure Function Relationships in Ion Channels Using Unnatural Amino Acids
... studies using traditional site-directed mutagenesis, incorporation of unnatural amino acids at each site resulted in channels with normal gating, substantially simplifying the ... See full document
345
Single-Molecule Studies of Ion Channels Expressing Unnatural Amino Acids
... mutagenesis of putative binding residues or single-channel analysis, where possible, for gating residues (Figure 3.8). The kinetic model of Scheme 3.1 refers to the nAChR, but it contains the essential features of any ... See full document
361
I Chemical Scale Studies of Ligand Gated Ion Channels, and II Novel Methods for Phosphonate Synthesis
... bound. Using nonsense suppression methodology, we have been able to specifically remove the backbone N-H in question by replacing αS191 with its α- hydroxy ... See full document
142
Ligand-Gated Ion Channels in Sensory Neurons
... A n o th e r p a r t of th e p ro ject w as to in v e s tig a te p o ssib le m ec h an ism s by w hich N G F m ig h t a lte r th e p ro p e rtie s of DRG neu ro n s. T he presence of tra n sc rip tio n factors w hich a ... See full document
275
Drug targets: ligand and voltage gated ion channels
... this ion channel is involved in synaptic transmission and signal transmission at neuro-muscular ...central ion conducting ...the ligand induces conformational change and results in influx of cations ... See full document
11
Investigation of the domain assembly in ligand-gated and voltage-gated ion channels using computational methods
... approaches using the afore men- tioned homology models, as the search space could not be specified precisely for ef- ficient pose ...Therefore, ligand based chemogenomics was applied in a first step by ... See full document
143
Synthesis of Photo/Chemical-Activated Nucleosides and Unnatural Amino Acids.
... through Unnatural Amino Acid Mutagenesis ...common amino acids. 247 The functional groups in these 20 amino acids, however, limited the flexibility in the design and improvement ... See full document
315
Functional modifications of acid-sensing ion channels by ligand-gated chloride channels
... acid-sensing ion channels (ASICs) and epithelial sodium channels (ENaC) constitute the majority of voltage- independent sodium channels in ...chloride channels but occurred with both ... See full document
13
Selective silencing of vertebrate neurons: strategies using invertebrate ligand-gated ion channels
... GIRK channels via coupling to G i/o ...GIRK channels either naturally or transgenically expressed, and because allatostatin is a peptide it will not cross the blood brain barrier and must by directly ... See full document
150
Identification of the prokaryotic ligand gated ion channels and their implications for the mechanisms and origins of animal Cys loop ion channels
... Results: Using sensitive sequence-profile searches we have identified homologs of ART-LGICs in several bacteria and a single archaeal genus, ...the ligand-binding and channel-forming transmembrane ... See full document
12
In Vivo Incorporation of Multiple Unnatural Amino Acids
... Kiowa Bower is always entertaining and marches to the beat of a different drummer. Jinti Wang was very hard working, good at multi-tasking, amazingly talented at getting experiments done with brute force, and extremely ... See full document
289
Nagase s Library of Unnatural Amino Acids
... A tryptic digestion assay of α-methyl phenylalanine-containing peptide was carried out to investigate the effect of α,α-dialkylamino acid residue on the protease resistance. The introduction of α,α-dialkylamino acid ... See full document
18
Nagase s Library of Unnatural Amino Acids
... A tryptic digestion assay of α-methyl phenylalanine-containing peptide was carried out to investigate the effect of α,α-dialkylamino acid residue on the protease resistance. The introduction of α,α-dialkylamino acid ... See full document
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