[PDF] Top 20 Chemical scale investigations of drug receptor interactions at the nicotinic acetylcholine receptor
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Chemical scale investigations of drug receptor interactions at the nicotinic acetylcholine receptor
... Increasing the number of aminopropyl side chains incorporated into a six-ring hairpin results in a corresponding enhancement of DNA-binding affinity. Previous studies demonstrate that moving the dimethylaminopropyl group ... See full document
172
Disruption of Drug Effects (Dopamine, Nicotine, Pilocarpine, κ Opioid) in Planarians by UV Light
... by receptor-binding ...D2 receptor antagonist (–)sulpiride ...selective nicotinic acetylcholine receptor agonist nicotine (1, 3, 5 mM) and the selective mus- carinic ... See full document
6
Chemical-scale studies of the nicotinic and muscarinic acetylcholine receptors
... Figure 1.7. Classic Zhong plot for αW149 residue of nAChR 11 Figure 2.1. Alignment of loops A and B for several Cys-loop receptors 17 Figure 2.2. Region investigated in Chapter 2 studies 18 Figure 2.3. Schematics of ... See full document
17
Noncovalent Interactions of Silent Agonists Binding to the Nicotinic Acetylcholine Receptor and Investigation into Expanding the Substrate Scope and Improving the Efficiency of Organic Photochemical Protecting Groups
... a chemical signal to cross the synaptic cleft (Figure ...molecule chemical signals that diffuse across the synaptic cleft and bind integral transmembrane receptors on the post synaptic ...to chemical ... See full document
123
Chemical-Scale Studies of the Nicotinic and Muscarinic Acetylcholine Receptors
... No object in nature is more complex than the human brain. The average adult brain contains more than one-hundred billion (> 10 11 ) neurons. Each neuron connects with one- to ten-thousand (10 3 –10 4 ) other neurons ... See full document
153
The Protective Effect of Alpha 7 Nicotinic Acetylcholine Receptor Activation on Critical Illness and Its Mechanism
... Wang et al. found that activation of α7nAChR could significantly block NF-κB signaling [32]. Various mechanisms were involved in interfering with NF-κB activation. For instance, α7nAChR-Janus kinase 2 (JAK2)-signal ... See full document
11
Lynxl and the β2V287L Mutation Affect the Stoichiometry of the α4β2 Nicotinic Acetylcholine Receptor
... consisting of a three-fingered folding motif and multiple internal disulfide bonds (Lyukmanova et al., 2011; Miwa et al., 1999). α-bungarotoxin and other such toxins exemplify a highly conserved receptor binding ... See full document
113
Actions of vesamicol on an alpha bungarotoxin sensitive neuronal nicotinic acetylcholine receptor
... In a separate series of experiments, membrane potential changes were recorded in response to ionophoretic applications of increasing doses of acetylcholine in the presence and absence of bath-applied ... See full document
10
Immunization with neuronal nicotinic acetylcholine receptor induces neurological autoimmune disease
... Neuronal nicotinic AChRs (nAChRs) are implicated in the pathogenesis of diverse neurological dis- orders and in the regulation of small-cell lung carcinoma ... See full document
8
RIC-3, a potential target for regulating cholinergic signaling and inflammation
... to acetylcholine) of the ...this receptor, likely to be the result of preferential interaction between RIC-3 and the DEG-3 subunit, leading to its preferential insertion into the mature receptor ... See full document
6
Mutation (G275E) of the nicotinic acetylcholine receptor alpha 6 subunit is associated with high levels of resistance to spinosyns in Tuta absoluta (Meyrick) (Lepidoptera: Gelechiidae)
... the nicotinic acetylcholine receptor alpha 6 subunit is associated with high levels of resistance to spinosyns in Tuta absoluta (Meyrick) (Lepidoptera: ... See full document
35
Preclinical pharmacology, efficacy, and safety of varenicline in smoking cessation and clinical utility in high risk patients
... 2 nicotinic acctylcholine receptors (nAChR) agonist, which has recently been approved by the US Food and Drug Administration (FDA) as a smoking cessation ... See full document
10
Single-Molecule Studies of Ion Channels Expressing Unnatural Amino Acids
... The kinetic model of Scheme 3.1 refers to the nAChR, but it contains the essential features of any allosteric system. There is a binding interaction with an allosteric effector and an intrinsic conformational change ... See full document
361
Structure and function prediction of human muscarinic acetylcholine receptor 1, cation-pi studies, and protein design
... the nicotinic acetylcholine receptor crystal structure complex ...aromatic-aromatic interactions, Asn 382 [6] forms hydrogen bonds to antagonists such as NMS, pirenzepine, and ...of ... See full document
106
Emerging Role of High-Mobility Group Box 1 (HMGB1) in Liver Diseases
... α7 nicotinic acetylcholine receptor agonist), EPC-K1 (the vitamin E derivative), mela- tonin, cisplatin and glycyrrhizin attenu- ate warm liver I/R damage partly through inhibition of HMGB1 release ... See full document
10
Nicotinic Acetylcholine Receptor-Mediated Protection of the Rat Heart Exposed to Ischemia Reperfusion
... that these neurons are a local source of acetylcholine. Recent studies have also identified the cardiomyocyte as a nonneuronal source of acetylcholine synthesis and secretion. Acting in an ... See full document
14
No evidence of a role of the β4 subunit of the nicotinic acetylcholine receptor in alcohol related behaviors
... this receptor subunit may not influence alcohol consumption, ataxia or sedation, but further work examining the involvement of this gene in ethanol withdrawal and locomotor stimulation may be ... See full document
10
The assembly and folding of neuronal nicotinic acetylcholine receptors
... The Torpedo nAChR is the most thoroughly characterised receptor in the superfamily of ligand-gated ion channels. The nAChR is an integral membrane glycoprotein of approximately 250 kD. It is a pentameric complex ... See full document
226
Reduction in mRNA and protein expression of a nicotinic acetylcholine receptor alpha 8 subunit is associated with resistance to imidacloprid in the brown planthopper, Nilaparvata lugens
... co-express insect nAChR a subunits with a vertebrate non-a subunit, such as rat b2 (Millar 2009). Previous studies of hybrid nAChRs expressed in Xenopus oocytes have indicated that Nla3 and Nla8 subunits are likely ... See full document
10
The Cholinergic Anti-inflammatory Pathway: A Missing Link in Neuroimmunomodulation
... the nicotinic acetylcholine receptor α7 subunit to endotoxin chal- lenge (105) implies a critical role of the cholinergic anti-inflamma- tory pathway in regulation of peripheral ... See full document
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