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[PDF] Top 20 Chemical-scale studies of the nicotinic and muscarinic acetylcholine receptors

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Chemical-scale studies of the nicotinic and muscarinic acetylcholine receptors

Chemical-scale studies of the nicotinic and muscarinic acetylcholine receptors

... Previous studies of a D89N mutant led to the proposal that a negative charge at D89 was essential for receptor ...our studies show that neutral side chains at position 89 function well, only if an ... See full document

17

Chemical-Scale Studies of the Nicotinic and Muscarinic Acetylcholine Receptors

Chemical-Scale Studies of the Nicotinic and Muscarinic Acetylcholine Receptors

... the fluorinated Trp series simultaneously at both residues should present the expected linear relationship between receptor response and cation-π binding energy. 3.3.4 Other Possible Cation- π Interaction Sites and ... See full document

153

Nicotinic acetylcholine receptors modulate osteoclastogenesis

Nicotinic acetylcholine receptors modulate osteoclastogenesis

... Conclusions Our results suggest that cholinergic agonists inhibit RANKL-induced osteclastogenesis by interfering with intracellular calcium levels and consequently with the NFATc1 signaling pathway. Of note, this ... See full document

12

Nicotinic acetylcholine receptors modulate osteoclastogenesis

Nicotinic acetylcholine receptors modulate osteoclastogenesis

... Thus nicotinic agonists at low concen- tration may favor the generation of osteoclasts, whereas high concentrations inhibit ...recent studies, which described increased in vitro osteoclasto- genesis as well ... See full document

12

Lynx1 Modulation of Nicotinic Acetylcholine Receptors

Lynx1 Modulation of Nicotinic Acetylcholine Receptors

... these α6L9’S mice and α-CTX MII, a toxin that specifically blocks α6* nicotinic receptors, we thought that we had good tools to study the effect of lynx1 on α6. Once we crossed the lynx1KO mice to the ... See full document

91

Lophotoxin insensitive nematode nicotinic acetylcholine receptors

Lophotoxin insensitive nematode nicotinic acetylcholine receptors

... Nematode nicotinic acetylcholine receptors (nAChRs) are molecular targets of several anthelmintic ...drugs. Studies to date on Caenorhabditis elegans and Ascaris suum have demonstrated ... See full document

8

The assembly and folding of neuronal nicotinic acetylcholine receptors

The assembly and folding of neuronal nicotinic acetylcholine receptors

... immunoprécipitation studies showing that when either rat a 4 or p2 are expressed alone, they can be detected at levels similar when they are co-expressed with subunits other than ...co-immunoprecipiation ... See full document

226

Chemical scale investigations of drug receptor interactions at the nicotinic acetylcholine receptor

Chemical scale investigations of drug receptor interactions at the nicotinic acetylcholine receptor

... the chemical, electrical, and mechanical signals that are delivered to ...studying receptors can produce high-precision insights into drug-receptor ... See full document

172

Binding Studies of Neuronal Nicotinic Acetylcholine Receptors Expressing Unnatural Amino Acids

Binding Studies of Neuronal Nicotinic Acetylcholine Receptors Expressing Unnatural Amino Acids

... the nicotinic pharmacophore by failing to make a functionally significant additional hydrogen bond to the backbone NH of a conserved leucine residue (L119 in rat ...other nicotinic agonists studied ... See full document

138

Structure-function Studies of Nicotinic Acetylcholine Receptors Using Unnatural Amino Acids

Structure-function Studies of Nicotinic Acetylcholine Receptors Using Unnatural Amino Acids

... 2.1 Abstract In the Cys loop superfamily of ligand-gated ion channels, a global conformational change, initiated by agonist binding, results in channel opening and the passage of ions across the cell membrane. The ... See full document

157

Structure-Function Studies of Nicotinic Acetylcholine Receptors Using Unnatural Amino Acids

Structure-Function Studies of Nicotinic Acetylcholine Receptors Using Unnatural Amino Acids

... muscle-type receptors. Chapter 3 extends studies of the point mutation near TrpB, termed the “loop B ...high-potency receptors have a lysine at this ... See full document

20

Effects of TI-299423 on Neuronal Nicotinic Acetylcholine Receptors

Effects of TI-299423 on Neuronal Nicotinic Acetylcholine Receptors

... Other studies have shown that any history of smoking at all decreases the probability of developing PD in the future [10, ...previous studies have suggested that α6β2*-nAChRs, which are primarily ... See full document

95

Molecular mechanisms of allosteric modulation of nicotinic acetylcholine receptors

Molecular mechanisms of allosteric modulation of nicotinic acetylcholine receptors

... Functional studies of slow onset desensitization have suggested the presence of a separate desensitization gate that extends from the -3’ to 9’ positions [Karlin 2002; Paas et ...of nicotinic ... See full document

176

Nicotinic acetylcholine receptors: specific antibodies and functions in humoral immunity

Nicotinic acetylcholine receptors: specific antibodies and functions in humoral immunity

... neuronal acetylcholine through α4β2 nAChRs sensitive to nanomolar doses of this ...by acetylcholine produced by activated T and B lymphocytes and affecting them locally within the immune ... See full document

10

Structure Function Studies of Nicotinic Acetylcholine Receptors Using Selective Agonists and Positive Allosteric Modulators

Structure Function Studies of Nicotinic Acetylcholine Receptors Using Selective Agonists and Positive Allosteric Modulators

... +(! mixture, which was subsequently submerged into the cooling unit containing 100% isopropanol at a temperature of -4°C to -6°C. Depending on flow rates, the buffer entered the oocyte chamber in the range of 13-16°C. ... See full document

157

Muscarinic and GABA A receptors modulate acetylcholine release in feline basal forebrain

Muscarinic and GABA A receptors modulate acetylcholine release in feline basal forebrain

... vivo studies have demonstrated that autoreceptors are functional even when a cholinesterase inhibitor is used for ...neostigmine, muscarinic antagonists cause concen- tration dependent increases in ACh ... See full document

11

Synthesis of Novel Allosteric Agonists and Allosteric Modulators for Nicotinic Acetylcholine Receptors

Synthesis of Novel Allosteric Agonists and Allosteric Modulators for Nicotinic Acetylcholine Receptors

... Figure 23 Bar graph of TQS compounds with type II PAM responses at the α7 nAChR 71 Although it is possible that the differences in size between fluorine and the other three halogens could explain the differences in ... See full document

255

Early life stress, nicotinic acetylcholine receptors and alcohol use disorders

Early life stress, nicotinic acetylcholine receptors and alcohol use disorders

... human studies have found an association between a family history of alcoholism and: left NAc volume in adolescent females [62]; resting state connectivity of the NAc [128]; and NAc connectivity during reward ... See full document

16

Gold nanoparticle–choline complexes can block nicotinic acetylcholine receptors

Gold nanoparticle–choline complexes can block nicotinic acetylcholine receptors

... of nicotinic acetylcholine receptors (nAChRs), and currents evoked by acetylcholine (Ach) can break these ...perfusion studies, the complex also blocked nAChRs by diminishing ... See full document

7

Block of nicotinic acetylcholine receptors by philanthotoxins is strongly dependent on their subunit composition

Block of nicotinic acetylcholine receptors by philanthotoxins is strongly dependent on their subunit composition

... recovery from blocking by PhTX-343 may be caused by its deep binding site in the pore where it may become ‘entrapped’ during channel closure. From previous studies, the mechanism of blocking of nAChR inward ... See full document

13

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