[PDF] Top 20 Chimeric Sindbis-Ross River viruses to study interactions between alphavirus nonstructural and structural regions.
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Chimeric Sindbis-Ross River viruses to study interactions between alphavirus nonstructural and structural regions.
... SIN viruses rescued from cDNA clones is similar or identical to the disease caused by the strain of virus from which the cDNA clone was derived (37, 53, ...two viruses, ... See full document
10
Adaptive Mutations in Sindbis Virus E2 and Ross River Virus E1 That Allow Efficient Budding of Chimeric Viruses
... 3⬘-nontranslated regions were derived from Ross River virus (RR) and the rest of the genome was derived from Sindbis virus (SIN), was almost nonviable because of a defect in budding ...(41). ... See full document
8
Molecular Genetic Study of the Interaction of Sindbis Virus E2 with Ross River Virus E1 for Virus Budding
... the chimeric heterodimer is cleaved and transported to the plasma membrane, it is not functional for ...incompatibilities between the two glyco- proteins must have arisen during speciation that lead to a ... See full document
6
Sindbis Virus Nonstructural Protein nsP2 Is Cytotoxic and Inhibits Cellular Transcription
... concentration in the cells and is apparently not involved in the alteration of cellular macromolecular synthesis as well. Of the two other nsPs, nsP2 is a better candidate as a critical factor in virus-host cell ... See full document
11
Sindbis-Group Alphavirus Replication in Periosteum and Endosteum of Long Bones in Adult Mice
... to alphavirus- mediated arthritis and arthralgia in humans has been ham- pered by the lack of a small-animal ...model. Sindbis-group al- phaviruses, Semliki Forest virus, and Ross River virus ... See full document
6
RNA Replication and Membrane Modification Require the Same Functions of Alphavirus Nonstructural Proteins
... Although SFV trans-replication is efficient overall (6), it may be that the RNA recruitment was inefficient or readily reversible under the conditions used, and in future work we will explore alternative methods, such as ... See full document
6
Catalytic Core of Alphavirus Nonstructural Protein nsP4 Possesses Terminal Adenylyltransferase Activity
... for interactions with nonstructural proteins or unidentified host factors in the replication complex (12, 27, ...of alphavirus nsP4 is replaced by SDD in influenza virus polymerase, by GDN in the ... See full document
8
Immunization with nonstructural proteins promotes functional recovery of alphavirus-infected neurons.
... NSV-induced disease. The severity of SV encephalomyelitis in mice is a predictable and reproducible biologic characteristic which is dependent on the route of inoculation, the strain of virus used for infection, and the ... See full document
5
Novel Functions of the Alphavirus Nonstructural Protein nsP3 C-Terminal Region
... this study, however, we were able to detect a rapid initial decline of the amounts of labeled nsP3 in SFV4- infected cells ...that alphavirus replication can inhibit nsP3 degra- ...the chimeric ... See full document
13
Chimeric Measles Viruses with a Foreign Envelope
... the chimeric vi- ruses, subconfluent Vero cells were infected with either the chimeric agents or the standard viruses, MV and VSV, at an MOI of ...rescued viruses induced different CPE from ... See full document
10
Synthesis of Sindbis virus nonstructural polypeptides in chicken embryo fibroblasts.
... 22, 1977 SINDBIS VIRUS NONSTRUCTURAL POLYPEPTIDES 421 in Sindbis virus-infected cells and show by tryptic peptide mapping and pulse-chase experiments that these polypeptides are synthesi[r] ... See full document
10
Structural and Nonstructural Proteins of an Arbovirus
... In Sindbis virus infection, it has been shown that virus structural proteins are the major proteins which are synthesized late in infection in actinomycin D-treated, infected chick cells[r] ... See full document
5
A second nonstructural protein functions in the regulation of alphavirus negative-strand RNA synthesis.
... By creating similar recombinant clones, the ts133 mutation was mapped to the Bi region Table 1, which contained Four members of the Sindbis superfamily 1, 7, 8, Sindbis virus SIN and Sem[r] ... See full document
6
A model for the dynamics of Ross River Virus in the Australian environment
... We consider two bulk populations, one consisting of kangaroos (denoted in the math- ematical model by the subscript k) and the other consisting of mosquitoes (represented with subscript m). Their populations are each ... See full document
20
Interactions between dengue type 3 viruses and human dendritic cells
... MHC class III region of the HLA genes encodes for other immune components such as complement proteins, tumor necrosis factor-alpha (TNF-α), and -beta (TNF-β). HLAs are found on the surface of all nucleated cells and ... See full document
156
Processing the nonstructural polyproteins of sindbis virus: nonstructural proteinase is in the C-terminal half of nsP2 and functions both in cis and in trans.
... From these results and from experiments in which processing was studied at increasingly higher dilution, we have concluded the following: i the viral nonstructural proteinase is located [r] ... See full document
12
Structural and Nonstructural Protein Genome Regions of Eastern Equine Encephalitis Virus Are Determinants of Interferon Sensitivity and Murine Virulence
... sensitivity between the North American and South American strains were more evident and because replication of both North American and South American strains was still ...and chimeric viruses (1,000 ... See full document
11
Structural and nonstructural proteins of a rabbit parvovirus.
... In the case of RPV, the F and G polypeptides do not seem to be the products of proteolytic cleavage of the structural proteins, because i the molecular weights of the F and G polypeptide[r] ... See full document
7
Alphavirus neurovirulence: monoclonal antibodies discriminating wild-type from neuroadapted Sindbis virus.
... To localize the molecular changes associated with neuroadaptation, we used a new array of 30 anti-SV monoclonal antibodies to probe for differences between SV and NSV in four tests: immu[r] ... See full document
10
Placement of the Structural Proteins in Sindbis Virus
... FIG. 1. CryoEM density distribution for Sindbis virus. Top left, surface of the virus at 20-A ˚ resolution. The red triangle marks the boundary of an icosahedral asymmetric unit. The numbers show the positions of ... See full document
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