[PDF] Top 20 Cholesterol, lipid rafts, and disease
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Cholesterol, lipid rafts, and disease
... manner. Cholesterol depletion of cells leads to decreased formation of PrPsc from PrPc. The GPI anchor is required for conversion. When the GPI anchor is exchanged with a transmembrane domain, conver- sion to ... See full document
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The Stability of Lipid Rafts Like Micro Domains Is Dependent on the Available Amount of Cholesterol
... of cholesterol, phosphatidylcholine, sphingomyelin, and lactose domains as the initial concentration of cholesterol is ...of cholesterol is ...of cholesterol in isolated lipid raft ... See full document
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Integrity of Membrane Lipid Rafts Is Necessary for the Ordered Assembly and Release of Infectious Newcastle Disease Virus Particles
... of lipid rafts on release of infectious ...in lipid raft domains, these results do not address the functional significance of lipid rafts as assembly ...of lipid raft domains in ... See full document
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Vaccinia Virus Penetration Requires Cholesterol and Results in Specific Viral Envelope Proteins Associated with Lipid Rafts
... require cholesterol-containing lipid ...of lipid rafts goes beyond their being treated simply as biochemical constituents of the plasma ...membrane. Lipid rafts are important ... See full document
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Severe Alterations in Lipid Composition of Frontal Cortex Lipid Rafts from Parkinson’s Disease and Incidental Parkinson’s Disease
... cortex lipid rafts. Therefore, we found it worthwhile to perform lipid analyses on frontal cortex phospholipids from the same samples where lipid rafts were ...and cholesterol ... See full document
12
Biliary lipid secretion in cholesterol gallstone disease The effect of cholecystectomy and obesity
... gallstone disease is initiated in a liver which produces abnormal bile with excess cholesterol relative to bile salts and ...biliary lipid secretion was measured by a duodenal marker perfusion ... See full document
14
Loss of parkin promotes lipid rafts-dependent endocytosis through accumulating caveolin-1: implications for Parkinson’s disease
... total cholesterol level and mem- brane ...regulate lipid rafts-dependent endocytosis ...the cholesterol level influences membrane fluidity, which can affect endocytosis ...regulates ... See full document
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Lipid rafts: linking prion protein to zinc transport and amyloid-β toxicity in Alzheimer's disease
... resistant lipid rafts was made. In another study, disruption of lipid rafts by cholesterol depletion reduced the interaction of Aβ with α -7-nicotinic acetylcholine receptors (Khan et ... See full document
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West Nile Virus Entry Requires Cholesterol-Rich Membrane Microdomains and Is Independent of αvβ3 Integrin
... of cholesterol-rich membrane microdomains, or lipid rafts, in the life cycle of WNV has not been investigated ...cellular cholesterol levels by brief treatment with methyl-  -cyclodextrin ... See full document
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Inhibition of HIV Replication by Apolipoprotein A I Binding Protein Targeting the Lipid Rafts
... cell lipid rafts are critically important for the biology of ...at lipid rafts of infected cells, and infection of target cells also involves lipid rafts ...of lipid ... See full document
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Cholesterol targeting alters lipid raft composition and cell survival in prostate cancer cells and xenografts
... endogenous cholesterol biosynthesis in LNCaP human PCa cells is capable of altering cell survival and signal transduction through the Akt serine-threo- nine kinase and its downstream ...the cholesterol ... See full document
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Human herpesvirus 6 envelope components enriched in lipid rafts: evidence for virion associated lipid rafts
... with lipid rafts, and this raft population is enriched in a cytoplasmic membrane fraction, which contains assembling and mature HSV particles, and the raft association of vhs is speculated to correlate with ... See full document
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Characterization of New Syncytium-Inhibiting Monoclonal Antibodies Implicates Lipid Rafts in Human T-Cell Leukemia Virus Type 1 Syncytium Formation
... in lipid rafts, we wanted to determine if these special- ized membrane domains were critically involved in HTLV- 1-induced syncytium ...formation. Cholesterol has been shown to be required for the ... See full document
11
Bioactive lipids are altered in the kidney of chronic undernourished rats: is there any correlation with the progression of prevalent nephropathies?
... -ATPase activity [22]; and (ii) failure in PKC driven regulation of key cellular processes as a result of reduced phosphoinositide turnover. Another point to be dis- cussed is the disruption of the crosstalk between gly- ... See full document
8
Analysis of detergent-free lipid rafts isolated from CD4+ T cell line: interaction with antigen presenting cells promotes coalescing of lipid rafts
... of lipid rafts that may undermine assessment of raft heterogeneity ...isolating lipid rafts from plasma mem- brane, we chose to isolate and characterize lipid rafts from a T-T ... See full document
13
A novel mechanism of regulating breast cancer cell migration via palmitoylation dependent alterations in the lipid raft affiliation of CD44
... outside lipid rafts in human glioblastoma cells has been shown to induce metalloproteinase-mediated CD44 shedding and tumour cell migration [31], which was further confirmed after membrane ... See full document
14
Oral Delivery of Protein Drugs: Driver for Personalized Medicine?
... membrane lipid rafts was further demonstrated by immunoblotting of intestinal subfractions of the plasma membrane with antibodies against human insulin and raft and non-raft ...with lipid ... See full document
13
Systems Virology Identifies a Mitochondrial Fatty Acid Oxidation Enzyme, Dodecenoyl Coenzyme A Delta Isomerase, Required for Hepatitis C Virus Replication and Likely Pathogenesis
... in lipid metabolism have long been observed in both experimental and clinical HCV ...Specific lipid species undergo changes in composition and abundance that facilitate molecular interactions required for ... See full document
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Downregulation of inhibitory SRC Homology 2 Domain-containing Phosphatase-1 (SHP-1) leads to recovery of T cell responses in elderly
... in lipid rafts which clearly showed a differential distribution in T cells of elderly and young individuals (Figure ...of lipid rafts in response to stimulation in the case of T cells of young ... See full document
17
Selective Association of Outer Surface Lipoproteins with the Lipid Rafts of Borrelia burgdorferi
... unique cholesterol-glycolipid-rich lipid rafts that are associated with ...of lipid rafts, and had similar lipid and protein slot blot ...with lipid rafts by ... See full document
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