[PDF] Top 20 Clinical feasibility of umbilical cord tissue derived mesenchymal stem cells in the treatment of multiple sclerosis

... At baseline, average time for the 25FWT Trial 1 was 17.43 s and 17.51 s for Trial 2 (Table 4). Overall mean time was 17.47 s, and average minimum time was 15.85 s. One month after treatment, average walk time for ... See full document

... human clinical practice and gener- ally used MSCs derived from adult tissues (bone marrow and adipose ...a clinical approach in ...thawed clinical-grade UC-derived MSCs in a relevant ... See full document

... antigen-presenting cells (APCs) ...and clinical studies have shown that autologous Tregs may have potential as a novel therapy in the treatment of autoimmune ...T cells because of their ... See full document

... of tissue regeneration, transplantation tolerance and control of ...person’s stem cells would be an excellent alternative option but it could be stalled by the availability of a suitable ...the ... See full document

... ® cells are a homogenous population of stem cells that comply with the current definition of mesenchymal stromal cell (MSC) as established by the International Society for Cellular Therapy ... See full document

... Background: Mesenchymal stem cells (MSCs) have been widely proven effective for therapeutic angiogenesis in ischemia animal models as well as clinical vascular ...adult ... See full document

... requires cells with the capability for proliferation, plasticity and functional integration into cardiac tissue ...(21). Stem cells feature unique regenerative potential and are consequently ... See full document

... /hypoxia treatment yielded approximately 4000-fold higher hUCB-MSC expansion over 7 weeks, whereas Ca 2+ or hypoxia alone increased proliferation by only 28- and 86-fold, ...This treatment resulted in a ... See full document

... received multiple transfusions and whose transfu- sion dependence was confirmed when the transplanta- tion was performed; patients who agreed to participate in HSCT; and all donors who were relatives to the ... See full document

... prevented tissue damage in CIA The immunosuppressive effects of UC-MSCs on T cells and FLSs in human RA promoted us to investigate the potential therapeutic effects of UC-MSCs in CIA, which is an arthritis ... See full document

... MSCs derived from various tissues with regard to their multipotency will be a significant advance for their clinical ...MSCs derived from various sources were positive for the expression of the MSC ... See full document

... years, mesenchymal stem cells have provoked much attentiveness in the field of regenerative medicine because of their differentiation potential and the capability to facilitate tissue repair ... See full document

... years, mesenchymal stem cells have provoked much attentiveness in the field of regenerative medicine because of their differentiation potential and the capability to facilitate tissue repair ... See full document

... After correcting of multiple comparisons by Bonferroni correction, the differences were considered significant at α = 0.017. Subgroup analysis of the primary outcome according to participants’ demographics and ... See full document

... that umbilical cord blood (UCB) is a source for hematopoietic stem cells, and transplantation of cord blood has been part of clinical practice for more than 10 ...contains ... See full document

... in clinical use for MS ...in Clinical Applications The epigenetic memory of iPSCs is a signature acquired from parental cells and the reprogramming process, which restricts the ability of iPSCs to ... See full document

... The injection was performed about 40 min with a speed of 40 drops per minute. During hWJC injection, other conventional therapies are used as usual. The patient was assessed by the investigators after receiv- ing the ... See full document

... I/II clinical trial with autologous, bone-marrow derived MSC in ...MSC treatment compared to placebo at 6 ...at clinical and MRI ...the MEsenchymal StEm cells for ... See full document

... that stem cell administration via intraven- ous and intrathecal infusions were well tolerated without immediate or long term side effects during the 24-week follow-up ... See full document

... remaining tissue containing both arteries and Wharton’s jelly was cut into small pieces and placed into a sterile 50 ml tube and incubated in collagenase type 1 (300 units/ml, Sigma) and hyaluronidase (1 mg/ml, ... See full document