[PDF] Top 20 Clinical features of De Novo acute myeloid leukemia with concurrent DNMT3A, FLT3 and NPM1 mutations
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Clinical features of De Novo acute myeloid leukemia with concurrent DNMT3A, FLT3 and NPM1 mutations
... AML DNMT3A/FLT3/NPM1 ) seems to have unique characteristics at the mRNA, miRNA, and epigenetic levels [1], its clinical features are not ...the clinical implications of ... See full document
10
DNMT3A mutations and clinical features in Chinese patients with acute myeloid leukemia
... DNMT2, DNMT3A, DNMT3B and DNMT3L ...RNA,. DNMT3A and DNMT3B are paralogous enzymes responsible for de novo DNA cytosine ...normal myeloid and lymphoid differentiation. By contrast, ... See full document
5
Biological and clinical influences of <em>NPM1 </em>in acute myeloid leukemia patients with <em>DNMT3A</em> mutations
... that DNMT3A mutations in AML had higher BM blasts, higher FLT3-ITD/TKD mutation rate, and higher IDH2 mutation rate when combined with NPM1 mutation, but little difference in prognoses ... See full document
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Original Article Double CEBPA mutations are prognostically favorable in non-M3 acute myeloid leukemia patients with wild-type NPM1 and FLT3-ITD
... CEBPA mutations on outcome has been extensively ...additional FLT3-ITD significant- ly worsen overall survival in the CEBPA-mutated group ...of FLT3-ITD on survival in the CEBPA-mutated group ... See full document
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<p>Acute myeloid leukemia patient with <em>FLT3-ITD</em> and <em>NPM1</em> double mutation should undergo allogeneic hematopoietic stem cell transplantation in CR1 for better prognosis </p>
... in acute myeloid leukemia (AML), and is reported in 25 – 30% of AML ...of FLT3 mutation, internal tandem duplication of FLT3 (FLT3-ITD) and tyrosine kinase domain of FLT3 ... See full document
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Acute Myeloid Leukemia—Genetic Alterations and Their Clinical Prognosis
... The FLT3 gene encodes a receptor tyrosine kinase (RTK) that plays a critical role in hematopoiesis and cell growth because it regulates diverse cellular processes such as proliferation, differentiation and ...in ... See full document
12
A clinical measure of DNA methylation predicts outcome in de novo acute myeloid leukemia
... and NPM1) and cytogenetic studies were performed; and who had undergone induction with an anthracycline and cytarabine (see ...with clinical outcome ...(26). FLT3-ITD and NPM1 status was ... See full document
11
Flow Cytometric Diagnosis of Acute Leukemia and Aberrant Antigen: Sohag University Experience
... Acute leukemia is a heterogeneous disease having diverse phenotypes. Immu- nophenotyping by flow cytometry is essential for diagnosis of myeloid and lym- phoid subtypes. This current study includes ... See full document
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The MERTK/FLT3 inhibitor MRX-2843 overcomes resistance-conferring FLT3 mutations in acute myeloid leukemia
... primary clinical effect of retinitis pigmentosa, likely due to defects in apoptotic clearance in the retina ...to FLT3 inhibition, the effects of inhibitors such as quizartinib have been well described, ... See full document
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CEBPA mutations in patients with de novo acute myeloid leukemia: data analysis in a Chinese population
... in two main hotspots: N-terminal out-of-frame insertions/deletions cause translation of a 30 kDa protein, from an internal ATG start site, that lacks transactivation domain 1 and has a dominant negative effect over the ... See full document
5
FLT3 inhibitors in acute myeloid leukemia
... dual FLT3/AXL inhibi- ...of FLT3/ITD-positive leukemia cells ...of FLT3 and its downstream targets in cell cultures as well as in animal ...in FLT3-mutated patients at doses ≥ 80 ... See full document
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www.ijcep.com /IJCEP712004 Case Report Diagnostic Challenges Related to Myeloid/Natural Killer Cells, a Variant of Myeloblasts
... on myeloid/NK acute leukemia entity were mainly of the latter form, which have been found to not be an uncommon type of AML and which have been classified under M0 by FAB and ...WHO. ... See full document
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Structural and functional Alterations of FLT3 in Acute Myeloid Leukemia
... processes, FLT3 activation plays a critical role in governing normal hematopoiesis and cellular ...Optimum FLT3 function requires the coordinated effort of other growth factors such as SCF, and ...early ... See full document
16
Pim kinase inhibition sensitizes FLT3-ITD acute myeloid leukemia cells to topoisomerase 2 inhibitors through increased DNA damage and oxidative stress
... in acute myeloid leukemia (AML), and is associated with short disease- free survival following ...by FLT3-ITD that also promotes its signaling in a positive feedback ...targeting ... See full document
16
Some aspects of allogeneic stem cell transplantation in patients with myelodysplastic syndrome: advances and controversy
... de novo MDS patients with IPSS low- or intermediate 1-risk groups, nontransplantation approaches were preferred. In contrast, for those patients in the intermediate 2- and high IPSS-risk categories, RIC ... See full document
8
Gilteritinib: a novel FLT3 inhibitor for acute myeloid leukemia
... patients, FLT3 mutations were seen in ...and de- creased ejection fraction were observed during the dose es- calation at the dose 40 mg/day of ... See full document
6
Detection of R882 Mutations in DNMT3A Gene in Acute Myeloid Leukemia: A Method Comparison Study
... of DNMT3A mutations detected in AML, ranges from ...Somatic mutations in the hotspot region of the DNMT3A gene (R882) were recurrently identified in ...that DNMT3A mutations ... See full document
9
Targeting Oncogenic Signaling in Mutant FLT3 Acute Myeloid Leukemia: the Path to Least Resistance
... new mutations in founding clones or one of their subclones, which then can undergo selection and clonal expansion ...with FLT3-ITD mutation often form resistance to TKIs following the acquisition of point ... See full document
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FLT3 inhibitors: clinical potential in acute myeloid leukemia
... diagnosed acute myeloid leukemia (AML) patients (pts) age 18–60 with FLT3 mutations (muts): an international prospective randomized (rand) P-controlled double-blind trial (CALGB ... See full document
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Mutational Analysis of FLT3 Internal Tandem Duplication and D835 in De novo Adult Acute Myeloid Leukemia
... Primers were obtained from a previous study performed by Yamamoto et al (forward 5’- CCGCCAGGAACGTGCTTG-3’ and reverse 5’- GCAGCCTCACATTGCCCC-3’) [13]. PCR was performed under the same conditions as for the FLT-ITD ... See full document
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