[PDF] Top 20 Clinical implication of the BRAFV600E mutation in papillary thyroid carcinoma
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Clinical implication of the BRAFV600E mutation in papillary thyroid carcinoma
... A total of 327 consecutive patients with PTC were en- rolled in this study and underwent thyroid surgery at Yeouido St Mary’s Hospital of the Catholic University in Seoul, Korea, between February 2010 and December ... See full document
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Clinical implications of the BRAF mutation in papillary thyroid carcinoma and chronic lymphocytic thyroiditis
... common thyroid cancer and gradually leads to remote metastasis, accounting for 88% of thyroid cancer ...the thyroid parenchyma through infiltration or fibrosis and is the most common inflam- matory ... See full document
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Detection of Plasma BRAFV600E Mutation Is Associated with Lung Metastasis in Papillary Thyroid Carcinomas
... showed minimal diffuse uptake in both lung fields, and chest CT showed micronodular lung metastasis in both lung fields. Thus, we regarded this patient as final TNM stage IVC. Thyroid tumor tissue and plasma ... See full document
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The relationship between the BRAFV600E mutation in papillary thyroid microcarcinoma and clinicopathologic factors
... Thyroid carcinoma is the most common endocrine malig- nancy and its prevalence is ...of thyroid ultrasound has led to the increased detec- tion of non-palpable thyroid ...nodules. ... See full document
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False negative BRAF V600E mutation results on fine needle aspiration cytology of papillary thyroid carcinoma
... BRAF mutation results, age should be consid- ered ...BRAF mutation rate, while the follicu- lar variant type has a relatively low BRAF mutation ...the clinical implications of these ... See full document
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Original Article Association between BRAF and RAS mutations, and RET rearrangements and the clinical features of papillary thyroid cancer
... Thyroid carcinoma is the most common endo- crine malignancy. Papillary thyroid cancer (PTC) accounts for majority of the thyroid carcinomas and its incidence are still on the rise ...on ... See full document
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Long-term vemurafenib treatment drives inhibitor resistance through a spontaneous KRAS G12D mutation in a BRAF V600E papillary thyroid carcinoma model
... V600E mutation with either MCL1 (pro-survival factor) copy number gain or P16 (tumor suppressor) ...with thyroid follicular cell ...G12D mutation, in addition to the existing BRAF V600E ... See full document
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Original Article Ultrasound features suspicious for malignancy predict the risk of BRAF mutation in papillary thyroid carcinoma
... BRAF mutation status in papillary thyroid carcinoma (PTC) on the basis of ultrasound (US) features suspicious for ...The clinical, pathologic, and radiologic characteristics of patients ... See full document
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BRAFV600E status and clinical characteristics in solitary and multiple papillary thyroid carcinoma: experience of 512 cases at a clinical center in China
... The mutation has been asso- ciated with both radioactive iodine refractoriness and PTC ...V600E mutation and clinicopathologic characteristics in ...V600E mutation was detected in 49% (570/1,168) ... See full document
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Expression of activator protein 1 in papillary thyroid carcinoma and its clinical significance
... of thyroid cancer has continued to rise in the past several decades world- wide ...of thyroid cancer reported and 6500 deaths in China, the national in- cidence of thyroid cancer was ...[2]. ... See full document
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Diagnostic utility of BRAFV600E mutation testing in thyroid nodules in elderly patients
... palpable thyroid nodules in iodine-sufficient regions ranges between 1% - 9% in adults ...of thyroid nodules are benign and the inci- dence of thyroid cancer is low, accounting for about 5% of ... See full document
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Associations between BRAFV600E and prognostic factors and poor outcomes in papillary thyroid carcinoma: a meta analysis
... V600E mutation is associated with several of the high-risk clinical variables used in prognostic staging systems, including extrathyroi- dal invasion, high TNM stage, lymph node metastasis, recurrence, and ... See full document
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Original Article Association between the BRAF V600E mutation and ultrasonographic features in papillary thyroid carcinoma: a study of 131 Chinese cases
... Papillary thyroid carcinoma (PTC) is the most common subtype of thyroid cancer, which ac- counts for 85-90% of thyroid carcinoma and its incidence has been increasing during ... See full document
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A thyroid gland with over 30 foci of papillary thyroid carcinoma with activating BRAF V600E mutation
... Decreasing density of malignant foci (arrows) with increasing distance from the central tumor. This phenomenon was observed in both thyroid lobes, but only representative images from the right side are depicted. ... See full document
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Three siblings with familial non medullary thyroid carcinoma: a case series
... classic papillary thyroid carcinoma, ...(right thyroid lobe). In addition, papillary microcarcinoma, Hürthle cell variant ...(left thyroid lobe) were reported as well with level ... See full document
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Diagnostic value of <em>BRAF<sup>V600E</sup></em>-mutation analysis in fine-needle aspiration of thyroid nodules: a meta-analysis
... shown in Table 1. In this meta-analysis, FNA cases classified as AUS/FLUS (Thy3a) and FN/SFN (Thy3f) were regarded as cytologically negative and lesions diagnosed as SMC (Thy4) were cytologically positive. Final ... See full document
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A preoperative diagnostic test that distinguishes benign from malignant thyroid carcinoma based on gene expression
... C1orf24 was described as a candidate marker for renal tumor, espe- cially in early-stage renal carcinogenesis (42). The pattern of gene expression showed that C1orf24 is expressed in normal muscle, pan- creas, colon, and ... See full document
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B-Raf and the inhibitors: from bench to bedside
... in thyroid carcinoma. The first study of B-Raf V600E in papillary thyroid carcinoma (PTC) detected such mutation in 24/35 (69%) of cancers ...V600E mutation in classic ... See full document
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The largest reported papillary thyroid carcinoma arising in struma ovarii and metastasis to opposite ovary: case report and review of literature
... respectively). Clinical and biochemical features of hyperthyroidism are uncommon in women with SO (< 5–8% of cases) [3, 5, 6], and whilst some reports observed no SO patients with overt hyperthyroidism symptoms ... See full document
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Original Article Warthin-like papillary thyroid carcinoma accompanying classical papillary carcinoma: report of three cases and systematic review of the literature
... of thyroid cancer, but had history of hyperthyroidism, which required medication to ...left thyroid gland, and the FNA result was suspicious for ...total thyroid- ectomy with ipsilateral ... See full document
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