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[PDF] Top 20 Clinical translation of human neural stem cells

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Clinical translation of human neural stem cells

Clinical translation of human neural stem cells

... for human cells and lineage markers showed robust engraftment, migration and differentiation to neurons (26 to 38%), astrocytes (3 to 8%) and oligodendrocytes (48 to 64%) ...by human oligoden- ... See full document

13

Simulated microgravity facilitates cell migration and neuroprotection after bone marrow stromal cell transplantation in spinal cord injury

Simulated microgravity facilitates cell migration and neuroprotection after bone marrow stromal cell transplantation in spinal cord injury

... including human neural stem cells [1], embryonic stem (ES) cell derivatives [2,3], and adult bone marrow stromal cells (BMSCs) [4-6], have been transplanted into the injured ... See full document

10

Induced in vitro differentiation of neural like cells from human exfoliated deciduous teeth derived stem cells

Induced in vitro differentiation of neural like cells from human exfoliated deciduous teeth derived stem cells

... the neural potential of stem cells from SHED. These cells are highly proliferative MSCs, located in dental pulp and potentially derived from neural crest cells, may be an optimal ... See full document

8

Ethical issues in stem cell research and therapy

Ethical issues in stem cell research and therapy

... nical translation begin with the need to ask a meaningful question, the answer to which has both scientific and so- cial value and can be reached by the study as designed when properly conducted ...into ... See full document

6

GMP-grade neural progenitor derivation and differentiation from clinical-grade human embryonic stem cells

GMP-grade neural progenitor derivation and differentiation from clinical-grade human embryonic stem cells

... neuroepithelial-like stem cell population, lt-NES, with stable neurogenic po- tential towards several neuronal sub-types [15, ...from clinical- grade hESC lines deposited in the UK Stem Cell Bank ... See full document

10

Nipah Virus Envelope-Pseudotyped Lentiviruses Efficiently Target ephrinB2-Positive Stem Cell Populations In Vitro and Bypass the Liver Sink When Administered In Vivo

Nipah Virus Envelope-Pseudotyped Lentiviruses Efficiently Target ephrinB2-Positive Stem Cell Populations In Vitro and Bypass the Liver Sink When Administered In Vivo

... 293T cells were cultured in Iscove’s modified Dulbecco’s medium (IMDM) with 10% fetal bovine serum (FBS), 1% minimal essential medium (MEM) nonessential amino acids (NEAA), 1% Glutamax, and ...(CHO) cells ... See full document

16

A scalable solution for isolating human multipotent clinical-grade neural stem cells from ES precursors

A scalable solution for isolating human multipotent clinical-grade neural stem cells from ES precursors

... hNSCs: Human fetal neural tissue – derived neural stem cells; GABA: Gamma- aminobutyric acid; GAD65 and 67: Glutamate decarboxylase 65 and 67; GDNF: Glial cell line-derived neurotrophic ... See full document

19

Electrical stimulation as a novel tool for regulating cell behavior in tissue engineering

Electrical stimulation as a novel tool for regulating cell behavior in tissue engineering

... of human induced pluripotent stem cells, muscle precursor cells, with the formation of embry- oid bodies [130, ...131]. Neural progenitor cells, neural pre- cursor ... See full document

12

Clinical application of stem cell therapy in Parkinson's disease

Clinical application of stem cell therapy in Parkinson's disease

... also could be used for autologous transplantation [34-37]. DA-ergic neurons were first generated from mouse iPSCs, transplanted into the striatum of a rat PD model and shown to ameliorate functional deficits [36]. ... See full document

7

A SY Stematic approach towards understanding stem cell biology

A SY Stematic approach towards understanding stem cell biology

... various stem cell research ...how stem cells make ‘ decisions ’ during early development and how stem cells function in the ...embryonic stem cells (ESCs), induced ... See full document

6

Therapeutic applications of stem cells from human exfoliated deciduous teeth: a review

Therapeutic applications of stem cells from human exfoliated deciduous teeth: a review

... The clinical applications of SHED demonstrated in animal models so far seem ...using stem cells as the first line of ...randomized clinical trials need to be conducted in adherence to ... See full document

5

The pregnancy hormones human chorionic gonadotropin and progesterone induce human embryonic stem cell proliferation and differentiation into neuroectodermal rosettes

The pregnancy hormones human chorionic gonadotropin and progesterone induce human embryonic stem cell proliferation and differentiation into neuroectodermal rosettes

... defined neural induction medium ...into neural tube-like rosettes after a total of 9 to 10 days of differentiation ...The neural induction medium was replaced every other ...in neural ... See full document

13

A novel, neural potential of non hematopoietic human umbilical cord blood stem cells

A novel, neural potential of non hematopoietic human umbilical cord blood stem cells

... adult stem cells extracted in vitro even from other than hematopoietic tissues have also a much broader plasticity of differentiation than originally antici- pated (Cao et ...for neural SC; Amoh et ... See full document

12

Rapid Neural Differentiation of Human Adipose Tissue-derived Stem Cells Using NGF, Forskolin and bFGF

Rapid Neural Differentiation of Human Adipose Tissue-derived Stem Cells Using NGF, Forskolin and bFGF

... One group of hADSCs were sustained in non-inductive control medium for 8 day, another group was induced toward the neurogenic lineages. The expression of MAP2, NSE and NFM was quantified for neurogenic samples. The same ... See full document

10

Nanog overexpression allows human mesenchymal stem cells to differentiate into neural cells——Nanog transdifferentiates mesenchymal stem cells

Nanog overexpression allows human mesenchymal stem cells to differentiate into neural cells——Nanog transdifferentiates mesenchymal stem cells

... Although stem cell therapies have been proposed as a candidate for treating neurological diseases, the best stem cell source and their therapeutic efficacy remain ...Embryonic stem cells ... See full document

13

New perspectives in human stem cell therapeutic research

New perspectives in human stem cell therapeutic research

... marrow stem cell mobiliza- tion be used to treat stroke despite little understanding of the possible mechanisms that may be ...involved. Clinical trials are underway and there is optimism that benefits will ... See full document

5

Stem cells in human neurodegenerative disorders — time for clinical translation?

Stem cells in human neurodegenerative disorders — time for clinical translation?

... of stem cells or their derivatives in animal models of neurodegenerative diseases can improve function by replacing the lost neurons and glial cells and by mediating remyelination, trophic actions, ... See full document

13

Bioprocessing strategies for the large-scale production of human mesenchymal stem cells: a review

Bioprocessing strategies for the large-scale production of human mesenchymal stem cells: a review

... a clinical dose of hMSCs (>200 × 10 6 cells), four to 10 four-layered cell factors were ...of cells and in harvest- ing could result in increased culture heterogeneity and suboptimal yield of ... See full document

10

Directly induced human Schwann cell precursors as a valuable source of Schwann cells

Directly induced human Schwann cell precursors as a valuable source of Schwann cells

... Schwann cells; iPSC: Induced pluripotent stem cells; hESCs: Human embryonic stem cells; NCSCs: Neural crest stem cells; hPSCs: Human pluripotent ... See full document

12

The nanomaterial toolkit for neuroengineering

The nanomaterial toolkit for neuroengineering

... of stem cell differentia- tion towards a pure, defined neural cell ...uncontrolled stem cell growth or differentiation after transplantation ...tent cells [14]) is clearly unacceptable for ... See full document

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