[PDF] Top 20 A clinically relevant gene signature in triple negative and basal like breast cancer
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A clinically relevant gene signature in triple negative and basal like breast cancer
... as triple nega- tive based on the mRNA expression of ER, PgR, and HER2 as previously described ...meta- gene definition and could also weaken the power of ...primary breast cancer gene ... See full document
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Cytotoxic Activity of Sphingosine-1-Phosphate against Human Triple-negative/ Basal-like Breast Cancer
... Breast cancer is one of the most common malignancy diagnosed in women and is the primary cause of cancer-related deaths in women ...HER2 negative breast cancer, known as ... See full document
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Basal-like breast cancer defined by five biomarkers has superior prognostic value than triple-negative phenotype.pdf
... Core Basal over 5NP tumors in the adjuvant anthracycline subset) are best considered hypothesis ...Core Basal definition may predict response of anthracycline-based adjuvant chemo- therapies needs ...in ... See full document
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Knockdown of CAVEOLIN-1 Sensitizes Human Basal-Like Triple-Negative Breast Cancer Cells to Radiation
... Introduction Breast cancer is one of the most common malignant diseases and a major cause of death among women worldwide ...that breast cancer is a heterogeneous disease with subtypes that ... See full document
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Cytotoxicity Study of Gold Nanoparticles on the Basal Like Triple Negative HCC 1937 Breast Cancer Cell Line
... The Triple Negative “Basal-like” breast cancer (TNBL) tumours have a high proliferative capacity and develop a resistance phenotype associated with me- ...a relevant tool ... See full document
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Understanding Triple Negative Breast Cancer
... Conclusion Triple negative breast cancer represents a distinct subtype of breast carcinoma which exhibits unique molecular and clinical ...expresses basal-like features ... See full document
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Triple Negative Breast Cancer Characteristics Based on Basal-like and Non-Basal-like Subtypes
... 8 Gene expression profile (GEP) examination divides TNBC into seven molecular subtypes ...i.e. basal-like 1, basal-like 2, mesenchymal (M), mesenchymal stem cell like (MSL), ... See full document
8
Gene expression profiling and histopathological characterization of triple negative/basal like breast carcinomas
... by gene- expression profiling ...a gene list of 534 genes that could accurately clas- sify 19 out of 21 medullary ...their signature on an independent dataset; therefore it is questionable whether ... See full document
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Triple-negative breast cancer with brain metastases: a comparison between basal-like and non-basal-like biological subtypes
... for triple-negative breast cancer was ...ductal cancer with histological grade 3 was detected, although medullary and metaplastic cancers were also ...most relevant sites of ... See full document
7
High MYC mRNA expression is more clinically relevant than MYC DNA amplification in triple-negative breast cancer
... TNBC, Gene Set Enrichment Analysis (GSEA) was conducted utilizing 50 hallmark gene sets [21] (Figure ...targets gene sets (v1: Normalized Enrichment Score (NES) = ...related gene sets that are ... See full document
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A two-gene epigenetic signature for the prediction of response to neoadjuvant chemotherapy in triple-negative breast cancer patients
... tive breast cancer than in ER ...classification. Basal-like 1 (BL1) subtype showed a pCR rate of 65.2%, while basal-like 2 (BL2) was ...in breast cancer including a ... See full document
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ANTINEOPLASTIC AND PROTEOMIC SIGNATURE OF SIMVASTATIN TREATED CD44+/ CD24- TRIPLE NEGATIVE BREAST CANCER STEM -LIKE CELLS
... in basal cell carcinoma , proteoglycon in cancer and insulin signaling pathways ( Figure ...of cancer stem ...in breast carcinoma affects the sensitivity of cancer to ... See full document
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A Genome-wide siRNA Screen Identifies Proteasome Addiction as a Vulnerability of Basal-like Triple-Negative Breast Cancer Cells
... all breast cancers and only about half of these are basal-like (Leh- mann et ...in basal-like ...for basal-like TNBCs? No individual cell line can hope to recapitulate the ... See full document
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SHP2 acts both upstream and downstream of multiple receptor tyrosine kinases to promote basal like and triple negative breast cancer
... between gene expression and protein stability, we speculate that SHP2 promotes FGFR1 and c-Met expression by acting at both protein and mRNA levels, similar to its role in EGFR ... See full document
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Breast cancer PAM50 signature: correlation and concordance between RNA-Seq and digital multiplexed gene expression technologies in a triple negative breast cancer series
... As displayed in Table 1 , we had 7 patients with dis- cordant subtype calls by the two techniques (7.3%). However, we observed that 3 patients had their second closest centroids within a distance ≤0.10 (range: 0.01 to ... See full document
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Identifying and characterizing functionally relevant microRNAs and 5’isomiRs in triple-negative breast cancer
... in Basal breast cancer patients: patients with high miR-1307-3p I0 / miR-1307-3p I1 levels were significantly depleted in an EMT gene signature, which is perfectly in line with my in ... See full document
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A gene expression signature identifies two prognostic subgroups of basal breast cancer: Multigene prognostic classification of basal breast cancers
... of breast cancer is heterogeneous and imperfectly captured by classical histoclinical features, making clinical evolution difficult to predict for a given patient and treatment not perfectly ...[1], ... See full document
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A computational approach to identify predictive gene signatures in Triple Negative Breast Cancer
... unique breast cancer samples with associated detailed clinical and outcome information and response to neo-adjuvant chemotherapy that allowed a statistically robust investigation of cancer ... See full document
148
Dysregulation of microRNAs in triple-negative breast cancer
... in basal like subtype of breast cancer and estrogen-negative ...of breast cancer patients and metastasis status ...with breast cancer in early postpartum ... See full document
7
A novel prognostic two-gene signature for triple negative breast cancer
... of cancer outcome, DMFS was chosen as an end point based on the high likelihood of TNBC patients being diagnosed with distant metastases within five years of diagnosis ...expressed gene panel presenting the ... See full document
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