[PDF] Top 20 Complex Cell Cycle Abnormalities Caused by Human T-Lymphotropic Virus Type 1 Tax
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Complex Cell Cycle Abnormalities Caused by Human T-Lymphotropic Virus Type 1 Tax
... the cell rounding characteristic of ...G 1 /senescence (red) thereafter without undergoing mitosis (cell rounding) and cell division (see cells marked with arrows in ...G 1 /S arrest ... See full document
9
Tax 1-Independent Induction of Vascular Endothelial Growth Factor in Adult T-Cell Leukemia Caused by Human T-Cell Leukemia Virus Type 1
... -negative cell lines. Having established that Tax 1 downregulates VEGF expression at a transcriptional level, we sought to determine its effect at the protein ...on cell culture supernatants ... See full document
7
The Major Histocompatibility Complex Class II Transactivator CIITA Inhibits the Persistent Activation of NF-κB by the Human T Cell Lymphotropic Virus Type 1 Tax-1 Oncoprotein
... inhibit Tax-1-dependent activa- tion of ...of Tax-1-dependent activation of NF- B, several dele- tion mutant forms of CIITA were analyzed for the ability to sup- press the NF- B-dependent ... See full document
14
Adenosine deaminase isoenzyme levels in patients with human T-cell lymphotropic virus type 1 and human immunodeficiency virus type 1 infections.
... Adult T-cell leukemia (ATL) is a disease entity caused by human T-cell lymphotropic virus type 1 (HTLV-1) infection, found predominantly in the ... See full document
5
Elevated Cyclic AMP Levels in T Lymphocytes Transformed by Human T-Cell Lymphotropic Virus Type 1
... vitro-HTLV-1-transformed cell line MT-2, from the ATLL-derived cell line StEd, and from postmitotic, uninfected primary CD4 ⫹ lymphocytes were ...continuous cell culture. Table 1 lists ... See full document
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Tax Interacts with P-TEFb in a Novel Manner To Stimulate Human T-Lymphotropic Virus Type 1 Transcription
... preinitiation complex to stably form on the DNA and transi- tion to the elongation ...in Tax transactivation is presented in Fig. 7. It is also possible that Tax inhibits P-TEFb kinase activity to ... See full document
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Modulation of the Brd4/P-TEFb Interaction by the Human T-Lymphotropic Virus Type 1 Tax Protein
... that Tax facilitates the release of P- TEFb from the HMW inactive complex to an active LMW P-TEFb complex composed of Tax/CDK9/cyclin ...LMW Tax/P-TEFb complex is in competitive ... See full document
8
Human T-Cell Lymphotropic/Leukemia Virus Type 1 Tax Abrogates p53-Induced Cell Cycle Arrest and Apoptosis through Its CREB/ATF Functional Domain
... either Tax or the Tax mutants, 2 mg of the CD20 expression vector, 1 mg of the PG13-Luc construct, and 1 mg of the pRL-TK reporter gene, as described ...by cell scraping, and ... See full document
9
Differences in the Ability of Human T-Cell Lymphotropic Virus Type 1 (HTLV-1) and HTLV-2 Tax To Inhibit p53 Function
... of Tax protein ex- pression using a panel of Tax antibodies including four Tax monoclonals (Tab 169, 170, 171, and 172) from our laboratory, three antibodies (IF7, 4C5, and 9F11) from ...in ... See full document
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Functional analysis of human T lymphotropic virus type 2 Tax proteins
... all Tax proteins using a single antibody, Tax coding sequences were amplified by PCR using reverse primers that contained an additional sequence for six histidine (HIS) residues before the stop ...sites. ... See full document
10
Human T-Lymphotropic Virus Type 1 Oncoprotein Tax Promotes S-Phase Entry but Blocks Mitosis
... of cell cycle entry coupled with inhibition of mitosis by Tax keeps the HTLV-1-infected cells in a metabolically active state for viral ...of Tax-expressing cells to exit the ... See full document
12
Interaction of the human T-lymphotropic virus type 1 Tax dimer with CREB and the viral 21-base-pair repeat.
... intact Tax protein that was not possible with short induction at 37 8 C using high concentrations of ...duty cycle for four burst of 1 min ...imidazole. Tax protein was then eluted with a ... See full document
7
Human T-Cell Lymphotropic Virus Type 1-Infected T Lymphocytes Impair Catabolism and Uptake of Glutamate by Astrocytes via Tax-1 and Tumor Necrosis Factor Alpha
... that T lymphocytes persistently infected with HTLV-1 may initiate functional perturbations in astrocytes by expressing inflammatory molecules and viral pro- teins, in particular ...with T cells ... See full document
9
Neutralizing human monoclonal antibodies to conformational epitopes of human T-cell lymphotropic virus type 1 and 2 gp46.
... notably human immunodeficiency virus (HIV) (41, ...leukemia virus (BLV), which is genetically much more closely related to ...of virus neutralization all recognized conformational epitopes (4, ... See full document
13
Examining Human T-Lymphotropic Virus Type 1 Infection and Replication by Cell-Free Infection with Recombinant Virus Vectors
... quantitative cell-free infection assay, utilizing recombinant human T-cell leukemia virus type 1 (HTLV-1)-based vectors, was developed in order to analyze early ... See full document
8
Induction of p21CIP1/WAF1expression by human T lymphotropic virus type 1 Tax requires transcriptional activation and mRNA stabilization
... normal cell cycle progression or by Tax may be causally linked to the activity of the APC/C E3 ...by Tax appear correlated [27], the stabilization of p21 may be a result of IKK or NF-κB ... See full document
13
Highly Enhanced Expression of CD70 on Human T-Lymphotropic Virus Type 1-Carrying T-Cell Lines and Adult T-Cell Leukemia Cells
... HTLV-1-transformed T-cell lines (8, 30), Jurkat cells expressing either p12I (26) or p30II (23), and the Jurkat cell line JPX-9 that can be induced to express higher levels of ... See full document
10
Human T-Lymphotropic Virus Type 1 Transcription and Chromatin-Remodeling Complexes
... C91/PL tax gene, and it is able to express a functional Tax protein, as assayed by CAT experiments for transactivation capability ...After 1 week, the remaining live cells (latent cells) were treated ... See full document
14
Induction of tumor necrosis factor alpha in human neuronal cells by extracellular human T-cell lymphotropic virus type 1 Tax.
... with 1% fetal bovine serum) or with Sp2/0 (control ascites diluted 1,000-fold in PBS with 1% fetal bovine serum) for 1 h at room temperature, followed by four washings for 15 min each with ...with ... See full document
8
Costimulation of cytokine gene expression in T cells by the human T leukemia/lymphotropic virus type 1 trans activator Tax.
... the Tax trans- activator from HTLV-1 functions mainly as a costimulator of cytokine genes in activated Jurkat T ...of Tax was capable of only low-level induction of GM-CSF and IL-3 mRNA, and ... See full document
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