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[PDF] Top 20 Computational analysis of antibody dynamics identifies recent HIV-1 infection

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Computational analysis of antibody dynamics identifies recent HIV-1 infection

Computational analysis of antibody dynamics identifies recent HIV-1 infection

... I, I/II, II, III, IV, V, and VI) (39). Additional antigens included multiple clade-specific and consensus linear pep- tides for the gp41 ID; V1, V2, V3, C1, and C5 epitopes; gp41 (ImmunoDx); p31 integrase (Jena ... See full document

12

A Reproducibility Based Computational Framework Identifies an Inducible, Enhanced Antiviral State in Dendritic Cells from HIV 1 Elite Controllers

A Reproducibility Based Computational Framework Identifies an Inducible, Enhanced Antiviral State in Dendritic Cells from HIV 1 Elite Controllers

... of HIV-1 reverse transcription product at early time points after ex vivo infection (Additional file 1: Figure S7), sug- gesting differences in molecular sensing pathways, rather than viral ... See full document

21

Human Immunodeficiency Virus (HIV) Antibody Avidity Testing To Identify Recent Infection in Newly Diagnosed HIV Type 1 (HIV 1) Seropositive Persons Infected with Diverse HIV 1 Subtypes

Human Immunodeficiency Virus (HIV) Antibody Avidity Testing To Identify Recent Infection in Newly Diagnosed HIV Type 1 (HIV 1) Seropositive Persons Infected with Diverse HIV 1 Subtypes

... monitor HIV inci- dence in the population of the United Kingdom has been previously described ...diagnosed HIV-1- infected persons, 24% of the infections were defined as being recently acquired, ... See full document

6

Dynamics of Viral Evolution and Neutralizing Antibody Response after HIV-1 Superinfection

Dynamics of Viral Evolution and Neutralizing Antibody Response after HIV-1 Superinfection

... Using computational and sta- tistical procedures for haplotype reconstruction and haplotype frequency, our study confirms the potential benefits of UDS for the analysis of the genetic diversity of viral ... See full document

8

The Dynamics of HIV-1 Adaptation in Early Infection

The Dynamics of HIV-1 Adaptation in Early Infection

... the dynamics of stochastic changes in allele frequencies caused by linked selection are different from those caused by other stochastic forces, Gillespie (2000) suggested that the strong effects of linked ... See full document

13

High prevalence of hepatitis B virus dual infection with genotypes A and G in HIV 1 infected men in Amsterdam, the Netherlands, during 2000 2011

High prevalence of hepatitis B virus dual infection with genotypes A and G in HIV 1 infected men in Amsterdam, the Netherlands, during 2000 2011

... A total of 1674 patients tested HBsAg positive in the AMC (Amsterdam, the Netherlands) during 2000-2011, of which 1008 were also tested for HIV-1 infection (HBV tests requested from outside the AMC, ... See full document

8

New therapy to revert dysfunctional antibody responses during HIV 1 infection

New therapy to revert dysfunctional antibody responses during HIV 1 infection

... Individuals infected with HIV-1 progress to AIDS at different rates. Rapid progressors develop AIDS within 2–5 years of initial infection, compared with approximately 10 years in typical progressors. ... See full document

5

Diagnostic performance of line immunoassay based algorithms for incident HIV 1 infection

Diagnostic performance of line immunoassay based algorithms for incident HIV 1 infection

... s antibody reaction in a widely used commercial line immunoassay, the Inno-Lia ™ HIV I/II Score (Inno-Lia), provides infor- mation on the duration of infection similar to that of a commercial enzyme ... See full document

15

Characterization of the Outer Domain of the gp120 Glycoprotein from Human Immunodeficiency Virus Type 1

Characterization of the Outer Domain of the gp120 Glycoprotein from Human Immunodeficiency Virus Type 1

... Strong antibody responses against the outer domain in rab- bits immunized with monomeric ...T-cell-line-adapted HIV-1 strains in vitro (3, 5, 6, 15, 25, 27, 39, 54, 65, 71; VaxGen, ...primary ... See full document

12

Tandem bispecific neutralizing antibody eliminates HIV 1 infection in humanized mice

Tandem bispecific neutralizing antibody eliminates HIV 1 infection in humanized mice

... improve HIV-1 neu- tralization breadth and potency, bispecific bnAbs (bs-bnAbs) have been engineered using the available gene sequences of bnAbs ...exquisite HIV-1–neutral- ization activity in ... See full document

14

Bridget_Wynn_masters_paper_final.pdf

Bridget_Wynn_masters_paper_final.pdf

... child HIV infection. The framework also identifies areas where local health departments and health care providers may have failed to identify HIV-infected mothers and opportunities to ... See full document

39

Antibody-dependent cellular cytotoxicity detects type- and strain-specific antigens among human immunodeficiency virus types 1 and 2 and simian immunodeficiency virus SIVmac isolates.

Antibody-dependent cellular cytotoxicity detects type- and strain-specific antigens among human immunodeficiency virus types 1 and 2 and simian immunodeficiency virus SIVmac isolates.

... ADCC titers in HIV-1 and HIV-2 antibody-positive sera against target cells infected with either autologous or allogeneic HIV-1, HIV-2, or SIVmac isolates Serum HIV-1 antibody positive B2[r] ... See full document

6

Negative Immune Regulator Tim-3 Is Overexpressed on T Cells in Hepatitis C Virus Infection and Its Blockade Rescues Dysfunctional CD4+ and CD8+ T Cells

Negative Immune Regulator Tim-3 Is Overexpressed on T Cells in Hepatitis C Virus Infection and Its Blockade Rescues Dysfunctional CD4+ and CD8+ T Cells

... viremic infection (HCV) demonstrate a more exhausted phenotype than those in a latent infection ...HCV infection status and compartment. As we and others have shown PD-1 to be a marker of ... See full document

9

Risk Factors for HSV 2 Infection among Sexual Partners of HSV 2/HIV 1 Co Infected Persons

Risk Factors for HSV 2 Infection among Sexual Partners of HSV 2/HIV 1 Co Infected Persons

... Data were entered onto standard case report forms and faxed to a central database at the University of Washing- ton. Analysis was done using SAS version 9.1 (SAS Insti- tute, Cary, NC). Univariate and multivariate ... See full document

6

Computational analysis of mRNA expression profiles identifies a novel triple-biomarker model as prognostic predictor of stage II and III colorectal adenocarcinoma patients

Computational analysis of mRNA expression profiles identifies a novel triple-biomarker model as prognostic predictor of stage II and III colorectal adenocarcinoma patients

... expression microarray data from primary colon adeno- carcinomas, liver metastasis and lung metastasis tissues. To find metastatic-specific markers, we initially compared gene expression profile between primary cancer ... See full document

8

Towards an epitope specific vaccine: Murine immune responses to wildtype and mutant HIV-1 gp120

Towards an epitope specific vaccine: Murine immune responses to wildtype and mutant HIV-1 gp120

... the analysis of the expressed w ildtype and m utant ...during analysis of IE alongside the w ildtype and other m utant proteins by SDS PAGE and W estern blots, IE protein was undetectable in the CHO ... See full document

237

Acute HIV infection presenting as hemophagocytic lymphohistiocytosis: case report and review of the literature

Acute HIV infection presenting as hemophagocytic lymphohistiocytosis: case report and review of the literature

... A diagnosis of acute HIV infection with secondary HLH was made based on criteria from the HLH-2004 trial [1]. A secondary diagnosis of acute kidney injury secondary to rhabdomyolysis occurring in ... See full document

5

Recent developments in the effort to cure HIV infection: going beyond N = 1

Recent developments in the effort to cure HIV infection: going beyond N = 1

... grated viral genomes that did not produce infectious virus while the cells were in a resting state but could do so following T cell acti- vation (4, 5). With the subsequent demonstration that this latent reservoir could ... See full document

7

Intracellular Dynamics of HIV Infection

Intracellular Dynamics of HIV Infection

... from infection to EGFP production may in part occur because of the variation in the time to proviral integration, if the completely reverse-transcribed DNA can persist in activated cells for similarly long periods ... See full document

12

A parameter sensitivity methodology in the context of HIV delay equation models

A parameter sensitivity methodology in the context of HIV delay equation models

... the HIV modeling field which focus heavily on the topic (good examples include [41, ...sensitivity analysis, a mathematical tool developed in the context of modern control theory and commonly used in ... See full document

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