[PDF] Top 20 Computational design of novel proteins for affinity reagents
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Computational design of novel proteins for affinity reagents
... binding affinity of antibodies against the respective ...similar affinity as the wild-type but a remarkably specific mode of ...a computational redesign of the SHV-1 beta lactamase/beta lactamase ... See full document
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Computational Design of Self-Assembling Proteins and Protein-DNA Nanowires
... occurring proteins, such as catalytic activity or protein/ligand binding, and apply them to new reactions or associations; and (3) functional designs that create large assemblies and novel functionalities ... See full document
159
Structure Guided Design and Biophysical Characterization of Novel Anti HIV Reagents
... to design potential structured linkers, we surveyed the Protein Data Bank (PDB) to find structures that were relatively elongated and rigid, or represented small globular proteins, with the idea of joining ... See full document
46
Computational Protein Design and Molecular Dynamics Simulations: A Study of Membrane Proteins, Small Peptides and Molecular Systems
... The SDF chemotactic homing mechanism is central to its ability to increase peri- infarct microvasculature and prevent mechanically inefficient ventricular contraction and eventual heart failure. Using a Boyden chamber ... See full document
169
Computational design of [beta] sheet proteins
... protein design has become a very powerful approach to test our understanding of the forces and energetics of macromolecular ...to design proteins that have specific structures and functions will be ... See full document
155
Computational Design Of Protein–ligand And Protein–protein Interactions
... of proteins is the concept of molecular ...protein design technology will therefore require an increased understanding of the design principles of molecular ...using computational methods to ... See full document
196
Current challenges facing the assessment of the allergenic capacity of food allergens in animal models
... of novel food ...the design of various animal models are reviewed, including among others considerations of species and strain, diet, route of administration, dose and formulation of the test protein, ... See full document
13
DESIGN, SYNTHESIS AND BIOLOGICAL EVALUATION OF NOVEL PYRROLO[2,1-c][1,4]BENZODIAZEPINE HYBRIDS AND PHENAZINE ANALOGUES
... It has been of considerable interest in the past few years to design and synthesize symmetrical cross-linking agents, particularly based on pyrrolobenzodiazepines (PBDs). Pyrrolo[2,1-c] [1,4]benzodiazepines (PBDs) ... See full document
19
Biospectroscopy diagnosis of bacterial interaction with environmental molecules
... 149 accessing chemical stimuli, and both chemo-attractant sensing and signal transduction play important roles in chemotactic behavior. As the c hemoreceptor protein, MCPs are able to recognize the periplasmic cognate ... See full document
196
Inverse QSAR approach and Molecular docking studies to design novel methoxy substituted Chalcones and their Computational Anticancer activity evaluation
... Target Structure Selection and Preparation: In structure- based computational techniques, it is crucial that we retrieve and use appropriate 3D structure of drug target. It is even more recommendable to prepare 3D ... See full document
5
Computational Evaluation and Mitigation of Wind-Driven Missile Impact against Condensate Storage Tanks and Associated Piping Connections
... preliminary design of the perforated barrier system was complete, a computational model of the system was developed and used to support detailed design activities and assess global stability of the ... See full document
10
NOVEL LIPOSOMAL GENE DELIVERY REAGENTS: DESIGN, SYNTHESIS, IN VITRO AND IN VIVO TRANSFECTION PROPERTIES
... rationale, design, synthesis, physico-chemical characterizations and in vitro gene delivery efficiencies (in HeLa, HepG2 and 293T7 cells) of a novel cholesterol based endosome pH-sensitive histidylated ... See full document
14
Computational Approach in Complex Structure Prediction for Drug Design Activity
... drug design activity obtained through the molecular binding of one molecule ...The computational process of searching for a ligand that is able to fit both geometrically and energetically the binding site ... See full document
6
Computational Biology of Ras Proteins
... interactions with the P-loop or switch II and V83 in Arf1 interacts with Rho numbered site K18, which H-bonds to GTP and GDP β and γ-phosphates (Sprang, 1997; PDB ID: 1HE8; Pacold et al. 2000; PDB ID: 1J2J; Shiba et al. ... See full document
246
Structural Insight into the Binding Interactions of Native and Mutant Structures of Dihydrofolate Reductases
... the computational analysis, the three-dimensional (3D) structures of native and mutant Dihydrofolate Reductase were taken from the crystal structures of Protein Data Bank ... See full document
5
Design thinking models for architectural education
... fundamental to ways of thinking and practising in a discipline. It can be applied to any discipline in higher education, but it is of particular importance for education in architecture where aesthetic, tactile ... See full document
6
Design and Optimization of a Novel Method for Extraction of Genistein
... a novel method of extraction of genistein from soy source which consists of a bioconversion reaction using fermentation by microorganism namely Streptomyces roseolus NRRL ... See full document
9
Functionalized Nano adsorbent for Affinity Separation of Proteins
... various proteins be- cause they are often inactive to visualization and fluores- cence techniques which can be used as sensitive biomolecular and medical diagnostic tools to combat bio- logical warfare ... See full document
8
From Literature to Alternate Reality Games: Prerequisites, Criteria, and Limitations of a Young Adult Novel’s Transformational Design for Educational Purposes
... the novel: Leros’ Code—redesigning should take not violate the basic narrative principles of the original text, the characters, the space-time settings, and its value ... See full document
18
Bead reagents for membrane proteins.
... faster than the corresponding reaction with iodoacetic acid. Chloroacetylation of aminoethyl beads via three commonly used peptide coupling reagents was surveyed, Table II, in each case with a 10-20-fold excess of ... See full document
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