[PDF] Top 20 Computational DIO2 rSNP Analysis, Transcriptional Factor Binding Sites and Disease
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Computational DIO2 rSNP Analysis, Transcriptional Factor Binding Sites and Disease
... rs225017 DIO2-T allele creates six unique potential TFBS for the HOXA5, ...enhancer binding, erythrocyte development, insulin activation, neuronal development and signal transduction (Table, ...rs225017 ... See full document
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VEGFA SNPs (rs34357231 & rs35569394), Transcriptional Factor Binding Sites and Human Disease
... protein/DNA binding electrophoretic mobility shift assays and lucerifase gene activation studies need to be conducted which is beyond the scope of this initial evaluation of these VEGFA SNPs and ... See full document
11
AKT3 rSNPs, Transcriptional Factor Binding Sites and Human Disease
... rs2345994) are significantly associated with the risk of RCC [6]. The rs4132509 AKT3-C allele creates one unique TFBS for the NFE2L1:MAFG TF, where NFE2L1 coordinates the up-regulation of cytoprotective genes via the ... See full document
14
ATF3 rSNPs, transcriptional factor binding sites and human etiology
... 6500 disease or trait-predisposing SNPs where only 7% of these are located in protein-coding regions of the genome [23,24] and the remaining 93% are located within non- coding areas [25,26] such as regulatory or ... See full document
9
Computational Analysis of Functional Sites in Proteins
... Of all the sequences present in the primary sequence databases, there are few which do not have a structural representative. Two particular examples have come to light very recently which do not have structures and which ... See full document
197
Computational Methods for Identifying and Characterizing the Human Gene Regulatory Regions and Cis-elements
... Many models have been developed to incorporate dependency information of positions. Motif models, such as Dinucleotide Weight Matrix Model (DWMM) (Schneider et al., 1986), Weight Array Model(WAM) (Zhang and Marr, 1993), ... See full document
201
Computational Predictions of G Protein Coupled Receptor Structures and Binding Sites
... snap binding energy. A combination of very low snap binding energies (top ten for that protein conformation), along with a desire for diverse poses was used to select six complexes for further study using ... See full document
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Variable structure motifs for transcription factor binding sites
... Sp1 binding motif from their ...the sites (see Figure ...the binding preferences of ...Sp1 binding sites are common in the genome, especially in promoters ...Sp1 binding ... See full document
20
Variable structure motifs for transcription factor binding sites
... Sp1 binding motif from their ...the sites (see Figure ...the binding preferences of ...Sp1 binding sites are common in the genome, especially in promoters ...Sp1 binding ... See full document
19
Simian virus 40 (SV40) T-antigen transcriptional activation mediated through the Oct/SPH region of the SV40 late promoter.
... This suggests that one function of T antigen in transcriptional activation of the late promoter is to alter factor binding at the Oct/SPH region to favor binding of factors to the SPH si[r] ... See full document
6
The demarcation of transcription factor binding sites through the analysis of DNase seq data
... the computational time required becomes prohibitive with an increase in the number of datasets being ...analysed. Computational as well as analytical challenges must be solved simultaneously in order to ... See full document
174
Genome Wide Mapping of Binding Sites Reveals Multiple Biological Functions of the Transcription Factor Cst6p in Saccharomyces cerevisiae
... replicate. Binding events were manually curated in the Integrative Genomics Viewer (40) to remove redundant events representing the same binding and false-positive events with poor peak shape or poor ... See full document
10
Co regulation by Notch and Fos is required for cell fate specification of intermediate precursors during C elegans uterine development
... Fig. 6. FOS-1 can directly bind to egl-13 URS as a heterodimer with JUN-1, which is also expressed throughout the uterus at cell specification. (A) EMSA with labeled 100 bp homologous template containing the Fos/Jun ... See full document
11
Expanding the Toolkit for Synthetic Biology: Frameworks for Native like Non natural Gene Circuits
... novo computational enzyme design because of its straightforward mechanism—one-step reaction where the transition state was stabilized through electrostatic interactions, and because of ab initio calcu- lations ... See full document
100
DNA Replication Efficiency Depends on Transcription Factor-Binding Sites
... transcription factor-binding sites in the regulatory region of variants help determine their rep- lication ...transcription factor-binding site combina- tion of one AP-1 site and two ... See full document
8
On the effect of mutations in bovine or camel chymosin on the thermodynamics of binding κ-caseins
... in computational alanine scanning, we show that similar results are obtained using the PSE-3, PC and PC+ functionals because the differences between these functionals partially cancel ... See full document
36
A PXR-Mediated Negative Feedback Loop Attenuates the Expression of CYP3A in Response to the PXR Agonist Pregnenalone-16α-Carbonitrile
... of analysis at the pathway level, rather than just the individual transcript level, as more information on likely biological effects can be ...GO analysis (GO5), commonly regulated biological pathways, ... See full document
15
SMCHD1 regulates a limited set of gene clusters on autosomal chromosomes
... with disease progression, other muscles may become ...transcription factor that is most abun- dantly expressed in the luminal cells of the testis and re- pressed in somatic cells [17, ... See full document
13
Regulation of bovine beta defensin expression
... transcription factor binding site prediction by comparison to a PWM database, it can also be used to discover motifs describing other types of DNA ...oPOSSUM3 analysis. Statistical analysis of ... See full document
283
Regulation of inflammatory responses by neuregulin-1 in brain ischemia and microglial cells in vitro involves the NF-kappa B pathway
... The alternative NF-kB pathway is thought to have anti-inflammatory and anti-apoptotic roles [31, 35]. The alternative pathway activates NIK, a member of the MAP kinase family, which activates IKK α , resulting in the ... See full document
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