[PDF] Top 20 Computational Predictions of G Protein Coupled Receptor Structures and Binding Sites
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Computational Predictions of G Protein Coupled Receptor Structures and Binding Sites
... G protein-coupled receptors (GPCRs) are the largest family of proteins within the human ...crystal structures an incomplete reflection of GPCR ... See full document
122
The Development and Application of Computational Methods for the Prediction of G Protein Coupled Receptor Structures
... of G protein-coupled receptors (GPCR) serve as neurotransmitters involved in many processes in the central nervous system, including the regulation of feeding, aggression, mood, perception, pain, and ... See full document
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COMPUTATIONAL ANALYSIS OF G PROTEIN COUPLED RECEPTOR SCREENING, DIMERIZATION, AND DESENSITIZATION
... a protein in the pathway. Comparisons between ligand binding in the membrane binding assay and the whole cell assay suggest that by manipulating the G-protein number, the membrane assay ... See full document
206
The Role of G Protein-coupled Receptor Kinases in Cancer
... either G-couple proteins or β-arrestin signaling or both, with a ligand known as "G-protein-biased agonist", "β-arrestin-biased agonist", or "balanced ...signaling protein, ... See full document
15
Role of Conformational Changes in G Protein-Coupled Receptor Activation
... (CB2) receptor is an attractive target for pain ...this receptor are less likely to cause unwanted psychoactive side ...sister receptor, human cannabinoid type 1 (CB1), using the GEnSeMBLE ... See full document
232
Multimodal Ligand Binding Studies of Human and Mouse G-coupled Taste Receptors to Correlate with their Species-Specific Sweetness Properties
... the receptor and contain ligand binding sites (figure ...the protein was cloned into both a HIS tag vector with a TEV cleavage site and a SUMO ...The protein was in the form of a ... See full document
27
Regulation of bone formation and remodeling by G protein coupled receptor 48
... Histology, in situ hybridization and immunohistochemistry Histological analysis, Hematoxylin and Eosin (HE) staining and lacZ staining were performed on paraffin-embedded tissues and histomorphometry was performed on ... See full document
10
Functional characterisation of the Anopheles leucokinins and their cognate G protein coupled receptor
... leucokinin receptor and immunolocalisation of the receptor Rabbit anti-peptide antibodies were raised against the epitope PHPDSGGESGGDGE (residues 531–543; Genosphere Technologies, Paris, ...leucokinin ... See full document
14
Current and future G protein-coupled receptor signaling targets for heart failure therapy
... world. G protein-coupled receptors, such as β-adrenergic and angiotensin II receptors, located in the membranes of all three major cardiac cell types, ie, myocytes, fibroblasts, and endothelial ... See full document
14
Complete reversible refolding of a G-protein coupled receptor on a solid support
... C-terminus (after residue Leu367) and contains a C-terminal tag of six histidine residues for purification. A segment, comprising residues 244 – 271, is also deleted. The construct contains eight point mutations: C116L ... See full document
16
G-protein coupled receptor expression patterns delineate medulloblastoma subgroups
... emerged. G-protein coupled receptors (GPCRs) possess characteristics that make them ideal targets for molecular imaging and therapeutics; drugs targeting GPCRs account for 30-40% of all current ... See full document
15
Modulation of G Protein-Coupled Receptor Intracellular Trafficking and Signal Transduction
... x g for 15 min at 4°C to pellet insoluble ...µg protein was incubated with 25 µL of FLAG M2-affinity beads for 1h rotating at 4°C to immunoprecipitate ...Rab8 protein using a primary goat anti-GST ... See full document
223
G‐protein coupled receptor‐mediated nutrient sensing and developmental control in Aspergillus nidulans
... the G-protein subunits and the mating MAPK cascade resulting in the activation of MpkB and subse- quently SteA, which are required for sexual development (Vallim et ... See full document
21
Expanding the Toolkit for Synthetic Biology: Frameworks for Native like Non natural Gene Circuits
... able to display the function and logic necessary for a controller, such as an “and” operation or an “on” signal, their use is often limited to a proof-of-concept or model examples, since they respond to signals related ... See full document
100
Role of C-C chemokine receptor type 7 and its ligands during neuroinflammation
... CCR7-deficient or plt/plt mice (lacking CCL19 and CCL21-Ser within secondary lymphoid organs) display gross alterations in the micro-architecture of spleen and thymus, and their DCs and T cells fail to home to the spleen ... See full document
9
14. Deisy Xavier Amora, Emmanuel Bresso, Roberto Coiti Togawa, Priscila Grynberg, Bernard Maigret and Natália Florêncio Martins
... G-protein coupled receptors (GPCRs) are the largest family of membrane proteins, as key components of signal transduction pathways. Despite the current knowledge, GPCRs in plants are not well ... See full document
16
Le Bris, Anna (2007): Overexpression and purification of membrane proteins in yeast: The GPCR Alpha-factor receptor and a methanococcal transporter. Dissertation, LMU München: Fakultät für Chemie und Pharmazie
... membrane protein are successful, usually one has to run the gauntlet in terms of preserving its native function during the subsequent purification ...the protein is indeed severely ...of protein ... See full document
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... Although associations between SNPs of GPR30 and sev- eral diseases, such as breast carcinoma [20], seminoma [27], and gynecomastia [28], have been investigated, this is the first study to investigate the association ... See full document
7
Aquatic adaptation and the evolution of smell and taste in whales
... taste receptor) [1]. Most of the taste receptor genes have also been lost from dolphin genomes [7,8], though behavioral tests indicate that dolphins can detect several kinds of flavorants ...anatomical ... See full document
10
The impact of the rs8005161 polymorphism on G protein-coupled receptor GPR65 (TDAG8) pH-associated activation in intestinal inflammation
... Studies in IBD genetics have identified more than 240 regions in the human genome that increase the risk of IBD [13–16]. The majority of IBD specific single nucleo- tide polymorphisms (SNPs) confer an increased risk for ... See full document
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