[PDF] Top 20 Contribution of BRCA1 5382insC mutation in triple negative breast cancer in Tunisia
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Contribution of BRCA1 5382insC mutation in triple negative breast cancer in Tunisia
... (71%) breast cancer patients with deleterious BRCA1 mutation exhibited triple negative ...the 5382insC muta- tion display a triple negative phenotype ... See full document
5
The Correlation Between PARP1 and BRCA1 in AR Positive Triple-negative Breast Cancer
... between BRCA1 and PARP1 due to the BRCA-PARP synthetic lethality, direct interactions between these two proteins also ...exist. BRCA1 inactivation due to mutation or promoter methylation is followed ... See full document
11
The prevalence of BRCA1 mutations among young women with triple-negative breast cancer
... mutation. Haffty et al. that reported that eight of 34 women with triple-negative breast cancer had a BRCA1 mutation (24%), but these included women with a strong family ... See full document
5
Triple-Negative Breast Cancer
... (888) 753-LBBC (5222) or via online chat at lbbc.org/helpline, who has made the same decision. If you are at high risk for breast cancer, especially if you have a BRCA mutation, you may discuss with ... See full document
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Triple negative Breast Cancer Patient
... AZD2281 Astra Zeneca Kudos Single agent ICEBERG1 PO Advanced BRCA mutation ICEBERG1 NCT00494234. AZD2281 NCI Carbo / AZD2281 IV/PO Phase I BRCA mutation NCT00647062 AG014699 CRUK / Univ [r] ... See full document
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Summary Report. Contribution of BRCA1/2 Mutation Testing to Risk Assessment for Susceptibility to Breast and Ovarian Cancer
... BRCA mutation testing ...and negative predictive value, 16 but disappointing specifi city 17 and positive predictive ...of breast cancer and these may become important tools for risk ... See full document
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Impact of Germline BRCA Mutation Status on Survival in Women with Metastatic Triple Negative Breast Cancer
... BRCA Mutation Status on Survival in Women with Metastatic Triple Negative Breast ...of Cancer Treatment and ...IV Breast Cancer ... See full document
6
Histopathological features of breast tumours in BRCA1, BRCA2 and mutation negative breast cancer families
... carrying BRCA1/2 mutations from other breast cancer ...of BRCA1 tumours, logistic regression analysis indicated that this was not an independent marker but was dependent on the age of ... See full document
8
Triple negative breast cancer
... A large number of therapies have been developed to date for specifi c molecular targets used as monotherapy or combined with traditional chemotherapy. Currently there are over 50 clinical trials assessing various thera- ... See full document
9
Triple-Negative Breast Cancer
... Beyond Breast Cancer in partnership with the Triple Negative Breast Cancer Foundation, this booklet will guide you through treatment and ...about triple-negative ... See full document
15
Triple-Negative Breast Cancer
... Beyond Breast Cancer in partnership with the Triple Negative Breast Cancer Foundation, this booklet will guide you through treatment and ...about triple-negative ... See full document
16
Basal cytokeratins in breast tumours among BRCA1, BRCA2and mutation negative breast cancer families
... There is much need for markers that could be used to distin- guish patients and families who are likely to carry a BRCA1/ BRCA2 germline mutation from mutation-negative families and from ... See full document
8
Functional Analysis Of Rad6 In Brca1 Wild Type And Brca1 Mutant Triple Negative Breast Cancer Drug Response
... In addition to taxanes and anthracyclines, therapies targeting the specific weaknesses of TNBCs are currently being investigated. It has been noted that TNBCs are highly vascularized to support their rapid proliferation ... See full document
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Absence of BRCA1 185delAG, BRCA1 5382InsC and BRCA2 6174delT among Hereditary Breast Cancer Patients in North Sumatera, Indonesia
... HinfI, DdeI and Pm1I respectively. The components for the reactions consisted of 13µL ddH 2 O, 2µL Buffer Tango, restriction enzyme 1µL and PCR product were mixed into PCR tubes. Spin down for a few seconds so that the ... See full document
9
Comprehensive molecular comparison of BRCA1 hypermethylated and BRCA1 mutated triple negative breast cancers
... National Breast Cancer Quality Registry (NKBC), Regional Cancer Center South, RBC Syd, and the South Sweden Breast Cancer Group ...Swedish Cancer Society CAN ...Swedish ... See full document
15
Understanding Triple Negative Breast Cancer
... Conclusion Triple negative breast cancer represents a distinct subtype of breast carcinoma which exhibits unique molecular and clinical ...some triple-negative cases along ... See full document
16
In treating triple negative breast cancer,
... These data are very interesting, but very preliminary. The Comet assay is a potential tool for identi- fication of DNA dam- age and prediction of sensitivity to DNA dam- aging therapy. Different chemotherapy agents can ... See full document
7
Increasing radiosensitivity by the combined inhibition of PARP1 and PI3K in BRCA1-mutated triple negative breast cancer
... 5 Xiamen Key Laboratory of Chiral Drugs, Medical College, Xiamen University, Xiamen 361005, People’s Republic of China ABSTRACT Background: To evaluate the radiosensitizing effect of co-targeting of poly (ADP-ribose) ... See full document
12
High prevalence and predominance of BRCA1 germline mutations in Pakistani triple-negative breast cancer patients
... of breast/ovarian ...higher BRCA1/2 mutation frequency observed in our study compared to those that evaluated unselected TNBC ...use BRCA1/2 prediction ...early-onset breast ... See full document
10
Carboplatin in BRCA1/2-mutated and triple-negative breast cancer BRCAness subgroups: the TNT Trial.
... IS - participant recruitment, data collection, Trial Management Group member; KMT - biological analyses; 72 .. AMW - participant recruitment, data collection, Trial Management Group mem[r] ... See full document
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