[PDF] Top 20 Contribution of FPR and TLR9 to hypoxia-induced chemoresistance of ovarian cancer cells
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Contribution of FPR and TLR9 to hypoxia-induced chemoresistance of ovarian cancer cells
... Cisplatin, chloroquine (CQ), tertiary butyl formyl oxygen (tBoc) and N-formylmethionyl-leucyl-phenylalanine (fMLF) were purchased from Sigma (Sigma-Aldrich Co., St Louis, MO, USA). TLR9, multidrug ... See full document
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Notch1 is required for hypoxia-induced proliferation, invasion and chemoresistance of T-cell acute lymphoblastic leukemia cells
... epithelial ovarian tumors and esophageal cancer showed that HIF-1α overexpres- sion correlated with tumor apoptosis and patient survival ...that hypoxia and HIF-1α, by re- ducing the proportion of ... See full document
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Tunneling nanotube formation is stimulated by hypoxia in ovarian cancer cells
... be induced under conditions of environmental stress characteristic of the tumor microenvironment such as ...hypoxia. Hypoxia is a hallmark of aggressively proliferating malignant tumors, and has been ... See full document
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Hypoxia-NOTCH1-SOX2 signaling is important for maintaining cancer stem cells in ovarian cancer
... the contribution of NOTCH to CSC formation has been suggested ...CSC-enriched ovarian cancer populations, including sphere cells, side population, and high-grade serous ovarian ... See full document
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Evaluating the benefits of neoadjuvant chemotherapy for advanced epithelial ovarian cancer: a retrospective study
... These results suggest that, R0 resection at PDS was as- sociated with the best prognosis. Debulking to RD < 1 cm provides a smaller but still significant benefit for pa- tients with PDS. For these patients, aggressive ... See full document
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KIAA0101, a target gene of miR-429, enhances migration and chemoresistance of epithelial ovarian cancer cells
... cell chemoresistance KIAA0101 has been reported involving in drug resist- ance in esophageal and hepatocellular cancers [19, ...COV644 cells with 8 µM Cisplatin for 24 h and then changed to complete medium ... See full document
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Natural agents mediated autophagic signal networks in cancer
... and induced autophagy via the Beclin-1 and AKT/mTOR ...prostate cancer cells ...acid induced accumulation of both LC3-II and p62 by activation of JNK in HCT15 ...treatment induced ... See full document
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Mechanisms of chemoresistance in cancer stem cells
... SP cells exhibit chemoresistance related to the ABC transporter expressed in these ...normal cells; P-glycoprotein (MDR1) and breast cancer resistance protein (ABCG2) ...protect cells ... See full document
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Original Article Knockdown of KIF3a inhibits hypoxia-induced epithelial-to-mesenchymal transition via suppression of the Wnt/β-catenin pathway in thyroid cancer
... thyroid cancer lines FTC133 and TPC1 were purchased from the American Type Culture Collection ...These cells were cul- tured in Dulbecco’s modified Eagle’s medium (DMEM), with supplements of 10% (v/v) fetal ... See full document
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Original Article MiR-204 inhibits cell growth and induces cell apoptosis though targeting RAB13 in ovarian cancer cells
... tumor cells include ovar- ian tumor. MicroRNAs 125a and 125b inhibit ovarian cancer cells through post-transcription- al inactivation of EIF4EBP1 ...its ovarian cancer metastasis ... See full document
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Hypoxia and neural stem cells: from invertebrates to brain cancer stem cells
... 7RGHWHUPLQHWKHUROHRI+,)_ in proliferation, survival and dopaminergic differentiation in vitro, as well as survival of murine dopaminergic neurons in vivo+,)_ was conditionally inactivated ... See full document
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MicroRNAs overexpressed in ovarian ALDH1-positive cells are associated with chemoresistance
... ALDH1(+) cells compared with ALDH1(−) cells to validate the ALDEFLUOR assay and the micro- array ...ALDH1(−) cells from SKpac-12, 16, and 17 ...(+) cells are expressed as fold-change relative ... See full document
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Ubiquitin E3 ligase MARCH7 promotes ovarian tumor growth
... tumor cells was scored as follows: 0 (absence of tumor cells), 1 (<33% tumor cells), 2 (33–66% tumor cells) and 3 (>66% tumor ... See full document
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Hypoxia shifts activity of neuropeptide Y in Ewing sarcoma from growth-inhibitory to growth-promoting effects.
... of hypoxia in ES ...vitro, hypoxia up-regulates EWS-FLI1 protein and modifies its transcriptional profile, promoting genes involved in tumor progression ...ES cells exhibit an enhanced ... See full document
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<p>Hypoxic non-small-cell lung cancer cell-derived exosomal miR-21 promotes resistance of normoxic cell to cisplatin</p>
... tumor cells on the sensitivity of normoxic tumor cells to cisplatin was ...SK-MES-1 cells treated with hypoxic tumor cell-derived and normoxic tumor cell-derived exosomes were exposed to cisplatin (0 ... See full document
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Galectin-3 supports stemness in ovarian cancer stem cells by activation of the Notch1 intracellular domain
... Ovarian cancer is the most lethal gynecologic disease because usually, it is lately sensed, easily acquires chemoresistance, and has a high recurrence ...that ovarian cancer stem ... See full document
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TGFBI promoter hypermethylation correlating with paclitaxel chemoresistance in ovarian cancer
... epithelial ovarian cancer(, 10 benign tumor and 10 normal ovarian tissues) were collected at the Department of Obstetrics and Gynecology, The Affiliated Hospital of Medical Col- lege, Qingdao ... See full document
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Tribbles homolog 3 denotes a poor prognosis in breast cancer and is involved in hypoxia response
... MDA-MB-231 cells were obtained after subcutaneous injection of 1 × 10 6 cells suspended in RPMI (MP Biomedicals, Illkirch, France) in six-week-old female athymic mice (BALB/c nu/nu, BonholdGard, ... See full document
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The role of peroxiredoxin II in chemoresistance of breast cancer cells
... for cancer resistance ...breast cancer cells and it is upregulated in head and neck cancer ...breast cancer cells and glioma cells leads to a significant reduction in cell ... See full document
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XIST lost induces ovarian cancer stem cells to acquire taxol resistance via a KMT2C-dependent way
... Long non-coding RNAs (lncRNAs) are a class of non- coding RNA molecules that are more than 200 nucleo- tides in length and do not encode proteins [7]. They are involved in many biological processes, such as participa- ... See full document
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