[PDF] Top 20 Contribution of NK cells to immunotherapy mediated by PD 1/PD L1 blockade
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Contribution of NK cells to immunotherapy mediated by PD 1/PD L1 blockade
... T cells, but is sensitive to NK cells (48). We generated PD-L1 transductants of B16 (hereafter abbreviated ...B16-Pdl1). NK cells infiltrating subcutaneous B16 tumors ... See full document
16
The role of PD-1 and PD-L1 in T-cell immune suppression in patients with hematological malignancies
... of PD-1 and PD-L1 expression character- istics in leukemia and lymphomas with defective T-cell immune responses have implications for the design of T- cell-based cancer immunotherapy, ... See full document
6
Oncolytic virus and PD-1/PD-L1 blockade combination therapy
... cancer cells and may thus be viewed as a form of ...protein 1 and programmed cell death ligand 1 signaling ...oncolysis, immunotherapy, immune checkpoint ... See full document
13
Noninvasive imaging of the PD-1:PD-L1 immune checkpoint: Embracing nuclear medicine for the benefit of personalized immunotherapy
... of PD-1:PD-L1 blockade occurring outside of the tumor microenvironment due to heterogeneity of PD-L1 expression in cancer lesions, which is not always correctly assessed ... See full document
12
PD-1 blockade attenuates immunosuppressive myeloid cells due to inhibition of CD47/SIRP aaxis in HPV negative head and neck squamous cell carcinoma
... suppressor cells (MDSCs) and tumor associated macrophages (TAMs) play key roles in the tumor immune suppressive network and tumor ...that PD-1 and PD-L1 levels were significantly higher ... See full document
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PD-L1 is upregulated by EBV-driven LMP1 through NF-κB pathway and correlates with poor prognosis in natural killer/T-cell lymphoma
... receptor 1 (PD-1) and PD ligand 1 (PD-L1) are important immune checkpoint molecules involved in T cell-mediated immune response and are key regulators of tumor ... See full document
12
The therapeutic promise of disrupting the PD-1/PD-L1 immune checkpoint in cancer: unleashing the CD8 T cell mediated anti-tumor activity results in significant, unprecedented clinical efficacy in various solid tumors
... of PD-L1, particu- larly when PD-L1 was expressed by tumor-infiltrating immune ...0, 1, 2, or 3 if <1%, ≥1% but <5%, ≥5% but <10%, or ≥ 10% of cells per ... See full document
5
Clinical Development of PD-1/PD-L1 Immunotherapy for Gastrointestinal Cancers: Facts and Hopes.
... inflammatory cells would attempt to destroy malignant cells, if this acute inflammatory response was insufficient to fully destroy the developing tumour, a dysregulation of the immune system could occur ... See full document
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Host expression of PD L1 determines efficacy of PD L1 pathway blockade–mediated tumor regression
... Therapeutic blockade of programmed death–ligand 1 (PD-L1, B7-H1) or programmed death protein 1 (PD-1) with mAbs leads to durable tumor control in a minority of patients ... See full document
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<p>Resistance Mechanism of PD-1/PD-L1 Blockade in the Cancer-Immunity Cycle</p>
... T cells, and promote its ...with PD-1 blockade, the tumor growth of IDO knockout mice was signi fi cantly delayed, and the overall survival rate was improved compared with wild type ...with ... See full document
12
Radiation therapy and PD-1/PD-L1 blockade: the clinical development of an evolving anticancer combination
... checkpoint blockade, immunologic memory was established in cured mice but not in treatment-naïve mice suggesting that the immune system in cured mice retained the ability to recognize tumor-associated antigens and ... See full document
17
PD-1 axis expression in musculoskeletal tumors and antitumor effect of nivolumab in osteosarcoma model of humanized mouse
... T cells to kill the tumor cells, and the quan- tity of TILs plays an important role in the immunotherapy ...with PD-L1/ PD-1 monoclonal antibody therapy showed a pattern ... See full document
13
Clinical heterogeneity of hypophysitis secondary to PD-1/PD-L1 blockade: insights from four cases
... starting PD-1/PD-L1 blockade, and only after 1 week in one patient treated with double blockade PD-1 and ...cases 1 and ...ACTH-producing cells ... See full document
6
PD-1/PD-L blockade in gastrointestinal cancers: lessons learned and the road toward precision immunotherapy
... with immunotherapy to elicit a response external to the radiation field ...of PD-1/PD-L and VEGF antibody merit further study ...checkpoint blockade by combining anti-PD-1 ... See full document
21
Basal cell carcinoma: PD-L1/PD-1 checkpoint expression and tumor regression after PD-1 blockade
... [27]. PD-L1 expression on tumor cells and immune cells has been shown to enrich for response to anti-PD-1/ L1 in various solid malignancies ...molecules, ... See full document
5
Challenges and potential of PD-1/PD-L1 checkpoint blockade immunotherapy for glioblastoma
... observed PD-L1 expression in 88% of newly diagnosed and ...measured PD-L1 expression in 94 glioblastoma patients and found that 61% of patients had tumours with PD-L1 positive ... See full document
13
Tumor cells versus host immune cells: whose PD-L1 contributes to PD-1/PD-L1 blockade mediated cancer immunotherapy?
... Antibody blockade of the PD-1/PD-L1 pathway has elicited durable antitumor responses in the therapy of a broad spectrum of ...cancers. PD-L1 is constitutively expressed in ... See full document
8
PD L1 on host cells is essential for PD L1 blockade–mediated tumor regression
... cancers. PD-L1 can be expressed in many different cells besides tumor ...of PD-L1 on tumor versus nontumor cells for immune eva- sion is still unclear (1, 22, ...of ... See full document
10
PD-1 blockade restores impaired function of ex vivo expanded CD8<sup>+</sup> T cells and enhances apoptosis in mismatch repair deficient EpCAM<sup>+</sup>PD-L1<sup>+</sup> cancer cells
... Background: Adoptive T cell therapy has been proven to be a promising modality for the treatment of cancer patients in recent years. However, the increased expression of inhibitory receptors could negatively regulate the ... See full document
13
Highly Pathological Influenza A Virus Infection Is Associated with Augmented Expression of PD-1 by Functionally Compromised Virus-Specific CD8+ T Cells
... STAT3- mediated proinflammatory signaling (23, ...T cells, leading to IL-6 produc- tion ...T cells, which was at least partially dependent on ...which PD-L1 also promotes SOCS3 ... See full document
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