[PDF] Top 20 The Correlation Between PARP1 and BRCA1 in AR Positive Triple-negative Breast Cancer

... process, PARP1 plays a curial role in the base-excision repair (BER) pathway for DNA single-strand breaks repair while DNA double-strand breaks are mainly repaired by homologous recombination repair (HRR) pathway ... See full document

... (FFPE) breast tissues used for microarray profiling consisted of 122 breast tumor samples obtained from patients undergoing surgery for breast cancer and 11 normal breast tissue samples ... See full document

... from BRCA1-IRIS for 72 h, treated with 5 μM of IRIS peptide for 24 h and for comparison cells were exposed to 10 μM of the PI3′K/AKT inhibitor; LY294002 (hereafter LY) or the ERK inhibitor; PD98059 (hereafter PD) ... See full document

... (implying M1-like phenotype) and the “NFκB on” subgroup (Figure 4A). Alternatively, the CD68:CD8 ratio can also be analysed through microarray analysis and this has been shown to predict survival and chemotherapeutic ... See full document

... Objective response in this study did not correlate with above studies but dis- ease stabilization response is comparable. Both the above studies comprised of hormone positive and hormone negative patients ... See full document

... of breast cancer combined also reported that the ALDH1A1 protein was a potential predictive marker of early local tumor recurrence and distant metastasis [9, ...of cancer stem cells in tissues and ... See full document

... Abstract: Triple-negative breast cancer (TNBC) is an aggressive histologically-defined cancer with a poor outcome for patients because there is a lack of targeted ...breaks. ... See full document

... expressing cancer cells by internalizing and trafficking to the lyso- some ...bearing BRCA1/2-mutated TNBC ...most breast cancers and promotes metastases by mediating intercellular adhe- sion, ... See full document

... Triple-negative breast cancers have a relapse pattern that is very different from hormone-positive breast cancers: the risk of relapse is much higher for the first 3–5 years but drops ... See full document

... the breast cancer prevalence, molecular subtypes and onset age among the different races and ethnicities, and because BRCA mutations are also different, caution must be exercised when following the clinical ... See full document

... invasive breast cancer ...metastatic breast cancer is based on the ER, PgR, and HER-2 status of the primary ...metastatic breast cancer have been reported to have discordances in ... See full document

... of breast cancer among young North American ...to BRCA1 and p53 ...association between any of the CHEK2 variants and breast cancer risk was ...a positive first-degree ... See full document

... the primary outcome of improvement in disease- free survival, both for HR-positive and TNBC populations. The benefit was most prominent in the TNBC subgroup (30% of patients), where 5-year disease-free survival ... See full document

... shuttle between nuclear and cytoplasm [35], whereas ER-α gene inactivation is mediated by PRB2 in ER-negative breast cancer cells ...in breast cancer; we speculate that it may ... See full document

... the positive rate of PD- L1 in TNBC was signi fi cantly higher than in ...in breast cancer, immune in fi ltrates have been shown to in fl uence response to therapy and prognosis in ... See full document

... Th e role of platinums was re-considered in TN tumors taking into account their mechanism of action and the potential DNA changes in these tumors, which are pheno typically and molecularly similar to BRCA1 tumors. ... See full document

... in BRCA1 mutated TNBC as compared to non mutated ...23 BRCA1-mutated and 21 non-mutated TNBC was studied by array ...similar between the two tumor groups and showed a high proportion of gains and ... See full document

... in BRCA1 expression, whether due to germline mutations in hereditary breast cancers or hypermethylation in sporadic breast cancers, could increase the risk of breast cancer in women at ... See full document

... ranges between 9% and 16% with a higher frequency in young women carrying BRCA1 gene mutation, showing a strong correlation with ethnic origin (in particular, African-American and Hispanic women) ... See full document

... for cancer diagnosis, especially because of the general absence or a significantly lower frequency of these TAAs or anti-TAAs autoantibodies in normal individuals and in non-cancer conditions [28, ...of ... See full document