[PDF] Top 20 Cryptococcus neoformans Gene Expression during Experimental Cryptococcal Meningitis
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Cryptococcus neoformans Gene Expression during Experimental Cryptococcal Meningitis
... Response to stress. Several tags corresponded to genes known to be involved in protein folding and the response to heat stress (Table 2). Heat shock proteins are produced in cells under conditions of stress and allow ... See full document
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Invasion of the Central Nervous System by Cryptococcus neoformans Requires a Secreted Fungal Metalloprotease
... Why Cryptococcus neoformans has this remarkable tropism for the CNS is not ...C. neoformans revealed a predominantly transcellular migration of cryptococci across the brain endothelium; however, the ... See full document
13
Induction of Protective Immunity to Cryptococcal Infection in Mice by a Heat Killed, Chitosan Deficient Strain of Cryptococcus neoformans
... C. neoformans could confer complete protective immunity came from studies of a ...C. neoformans H99 strain that was engineered to express and secrete murine gamma interferon ...C. neoformans (strain ... See full document
14
Microevolution of Serial Clinical Isolates of Cryptococcus neoformans var grubii and C gattii
... recurrent cryptococcal meningitis ...of Cryptococcus has been documented in several cases of recurrent infection as well as by in vitro and in vivo experiments ...recurrent cryptococcal ... See full document
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Microevolution During Serial Mouse Passage Demonstrates FRE3 as a Virulence Adaptation Gene in Cryptococcus neoformans
... upregulated gene in macrophages in previous studies (51), although more recent studies did demonstrate upregulation of iron uptake genes such as the CFO1-encoded ferroxidase from “in situ” human cerebrospinal ... See full document
11
Dynamics of Cryptococcus neoformans Macrophage Interactions Reveal that Fungal Background Influences Outcome during Cryptococcal Meningoencephalitis in Humans
... of Cryptococcus neofor- mans clinical (ClinCn) isolates influences the interaction with host cells and the clinical outcome, we developed and validated new quantitative assays using flow cytometry and J774 ... See full document
10
RNA Interference in the Pathogenic Fungus Cryptococcus neoformans
... Cryptococcus neoformans is a pathogenic fungus responsible for serious disease in immunocompromised ...an experimental system, with initiation of a ge- nome project among other molecular ...of ... See full document
8
Role of an Expanded Inositol Transporter Repertoire in Cryptococcus neoformans Sexual Reproduction and Virulence
... of gene expression (SAGE) has been applied to characterize gene expression profiles during experi- mental cryptococcal meningitis in a rabbit model ...INO1 gene and ... See full document
14
A prospective descriptive study of cryptococcal meningitis in HIV uninfected patients in Vietnam high prevalence of Cryptococcus neoformans var grubii in the absence of underlying disease
... C. neoformans was identified by the demonstration of budding encapsulated yeasts on India ink stain of cere- brospinal fluid (CSF). CSF pellets were cultured at 35°C on chocolate and blood agar, brain-heart ... See full document
8
Mixed Infections and In Vivo Evolution in the Human Fungal Pathogen Cryptococcus neoformans
... C. neoformans populations in the environment and suggested that their function may be to generate genetic diversity de novo during the sexual cycle ...to cryptococcal cells by allowing rapid ... See full document
9
Microsatellite typing and susceptibilities of serial Cryptococcus neoformansisolates from Cuban patients with recurrent cryptococcal meningitis
... C. neoformans isolates, even though it has pro- ven to be more active in vivo ...an experimental broad-spectrum antifungal triazole active against clinically relevant yeasts and moulds ... See full document
7
The Cryptococcus neoformans Transcriptome at the Site of Human Meningitis
... ABSTRACT Cryptococcus neoformans is the leading cause of fungal meningitis ...the cryptococcal transcriptome under various stress conditions, but a comprehensive profile of the ...C. ... See full document
10
Most Cases of Cryptococcal Meningitis in HIV Uninfected Patients in Vietnam Are Due to a Distinct Amplified Fragment Length Polymorphism Defined Cluster of Cryptococcus neoformans var grubii VN1
... A further possibility is that the VNI ␥ cluster may represent strains with increased pathogenicity. If this is the case, an explanation is needed as to why it is not the dominant genotype causing disease in HIV-infected ... See full document
7
Ordered Kinetochore Assembly in the Human Pathogenic Basidiomycetous Yeast Cryptococcus neoformans
... C. neoformans FIG 3 Ordered kinetochore assembly in ...clustered during mitosis (middle three ...visible during mitosis (t ⫽ 16 to 27 min) and disappeared soon after chromosome segregation, while ... See full document
8
Experimental modulation of capsule size in Cryptococcus neoformans
... The increase of capsule size during infection is believed to be biologically significant because of the virulence-enhancing properties of capsular polysaccharide. It is thought that this increase in capsule size ... See full document
6
Cryptococcosis Serotypes Impact Outcome and Provide Evidence of Cryptococcus neoformans Speciation
... whatever the infecting serotype for the patients enrolled in the CryptoA/D study. Virulence of AD hybrids has been assessed in experimental infections using relatively few strains (12, 32, 34). The mating type, ... See full document
12
Capsule Growth in Cryptococcus neoformans Is Coordinated with Cell Cycle Progression
... Strains and culture conditions.Cryptococcus neoformans var. grubii strain H99 (71) and the cln1 mutant strain CNAG_06092, obtained from a col- lection of mutants deposited at the ATCC by H. D. Madhani (20), were ... See full document
13
Ab binding alters gene expression in Cryptococcus neoformans and directly modulates fungal metabolism
... mAb binding to C. neoformans is associated with changes in protein phosphorylation. (A) Autoradiogram of phosphorylated proteins in cell lysates with and without mAb. (B) Graph of the total pixels for each band in ... See full document
8
Lipid Flippase Subunit Cdc50 Mediates Drug Resistance and Virulence in Cryptococcus neoformans
... C. neoformans to overcome the antifungal activity of ...C. neoformans in the J774 macrophage cell line was measured in 48-well ...C. neoformans H99, cdc50 ⌬ , and cdc50 ⌬⫹ CDC50 strains were added to ... See full document
13
Unraveling Melanin Biosynthesis and Signaling Networks in Cryptococcus neoformans
... The gene deletion mutants used in this study are listed in Table ...Each gene disruption cassette contained nourseothricin, G418, or hygromycin B selection marker (NAT, NEO, or HYG, respectively) and was ... See full document
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