[PDF] Top 20 Cytotoxicity Analysis of Some Novel Pyrimidine Derivatives
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Cytotoxicity Analysis of Some Novel Pyrimidine Derivatives
... of pyrimidine core is mainly due to their valuable pharmacological ...synthetic pyrimidine and fused pyrimidine pharmacophores exhibit antibacterial, antiviral, antimicrobial, anticancer, cytotoxic, ... See full document
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Synthesis and Characterization of Some Heterofused Pyrimidine Derivatives
... thiazolidine derivatives, for instance, pidotimod[26] and CGP52608[27] exhibited strong immunostimulating ...synthesize some novel dihydropyrimidine derivatives associated with thiadiazoles ... See full document
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Design, synthesis, docking, and antimicrobial evaluation of some novel pyrazolo[1,5-<em>a</em>]pyrimidines and their corresponding cycloalkane ring-fused derivatives as purine analogs
... of a signal at δ 8.54 ppm assigned for pyrimidine-H proton, two multiplets at a range of δ 2.52–3.33 ppm assigned for three CH 2 groups, and two broad singlets at δ 7.48–7.57 and 9.69 ppm assigned for NH 2 and NH ... See full document
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Synthesis and evaluation of some novel heterocyclic compounds containing pyrimidine and thiazolidinone rings and their Derivatives as an antimicrobial agents
... phenyl) pyrimidine and their derivatives are known for their biological ...resultant pyrimidine compounds are ...thiazolidine-4-one derivatives are prepared by using thioglycolic ...Elemental ... See full document
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SYNTHESIS OF NOVEL PYRIMIDINE AND FUSED PYRIMIDINE DERIVATIVES AND THEIR IN VITRO ANTIMICROBIAL AND CYTOTOXIC EVALUATION
... work some novel pyrimidine and fused pyrimidine derivatives were prepared starting from 1-allyl-2-hydrazinyl-4-oxo-6- (3, 4, 5-trimethoxyphenyl)-1, 4-dihydropyrimidine-5-carbonitrile ... See full document
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H NMR, 13 C NMR, mass spectra and elemental analysis. All the
... a novel series of pyrazolo[3,4-d]pyrimidine derivatives by incorporating the phenothiazine and pyrazolo[3,4- d]pyrimidine in a single molecular framework with a potential spectrum of ... See full document
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Synthesis and Cytotoxicity of Novel Hexahydroquinoline benzenesulfonamide Derivatives
... All melting points are uncorrected and were recorded on an open glass capillary tubes using an Electrothermal IA 9100 digital melting point apparatus. Elemental microanalyses were carried out at Micro analytical Unit, ... See full document
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SYNTHESIS OF NOVEL PYRIMIDINE DERIVATIVES AS POTENTIAL ANTIMICROBIAL AGENTS
... Some novel Pyrimidine derivatives were synthesized from the reaction of various substituted Chalcones with Hydrazine ...elemental analysis, IR and 1H-NMR spectral ...activity. ... See full document
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Synthesis, Characterization and Antitumor Activity of Some Novel Pyrimidine Sulfonamide Derivatives
... of pyrimidine-5-sulfonamides ...condensed pyrimidine derivatives incorporating sulfonamide moiety such as: imidazopyrimidine 3a,b, pyrimidoquinazoline 4a,b and pyrimidothiazine derivatives ... See full document
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NOVEL SYNTHESIS OF OXADIAZOLE DERIVATIVES WITH PYRIMIDINE MOIETY
... The biological and synthetic significance places this scaffold at a prestigious position in medicinal chemistry research so we have developed an operationally simple, inexpensive, efficient and environmental benign ... See full document
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Synthesis, spectral and microbial studies of some novel schiff base derivatives of 2 amino pyrimidine
... base derivatives of N-(1Z)-[((mono or di-substituted aryl)-1,3-diphenyl-1H-pyrazol-4-yl) methylene]-4,6- dimethoxy pyrimidine-2-amine were synthesized by the acid catalyzed condensation of (mono- or di- ... See full document
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IN VITRO ANTIBACTERIAL AND CYTOTOXICITY EVALUATION OF SOME NOVEL TETRAZOLE DERIVATIVES
... Chemistry: Melting points were recorded in open capillary tubes and were uncorrected. The IR spectra were recorded in KBr on an FT-IR spectrometer (Shimadzu 8201PC) in the range of 4000-400 cm -1 . The 1 H NMR spectra ... See full document
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SYNTHESIS, ANTIMICROBIAL ACTIVITIES OF SOME NOVEL PYRIDINE AND PYRIMIDINE DERIVATIVES
... chemical shift values are expressed in ppm (δ scale) using tetramethylsilane as an internal standard. The mass spectral measurements were carried out by Electron Impact method on JEOL GC mate spectrometer at 70 eV. ... See full document
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SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF SOME NOVEL 1 PHENYL 1 H PYRAZOLO[3,4 D]PYRIMIDINE DERIVATIVES
... its derivatives as well as nicotinic acid hydrazide resulted in the formation of compounds (8a-f) scheme ...of novel targets was confirmed by 1HNMR, 13CNMR, Mass Spectrometry and elemental ... See full document
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SYNTHESIS, ANTI VIRAL AND CYTOTOXICITY STUDIES OF SOME NOVEL N SUBSTITUTED BENZIMIDAZOLE DERIVATIVES
... newer derivatives against HIV based upon promising antiviral activity ...quinazolinone derivatives with sulphanamide against biodefence viruses in cell culture 5 ...of some of them exceeded those of ... See full document
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A Facile Synthesis and Docking Studies of N-(3-(4-Chlorophenoxy)benzyl)-2-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine
... the pyrimidine nucleous: pyrrolo[2.3-d]pyrimidine, ...aminopyrroles. Pyrimidine derivatives have occupied a unique position in medicinal chemistry; the pyrimidine ring is present in a ... See full document
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Measurement of Density, Refractive Index and Conductance of Some Pyrimidine Derivatives in Solutions at 308.15 K.
... 2. S Gorle, S Maddila, S Chokkakula, P Lavanya, M Singh, et al. (2016) Synthesis, Biological Activity of Pyrimidine Linked with Morpholinophenyl Derivatives. J Heterocyc Chem 53: 1852-1858. 3. S El Bahaie, ... See full document
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SYNTHESIS AND EVALUATUION OF SOME NOVEL MERCAPTOBENZIMIDAZOLE DERIVATIVES
... mercaptobezimidazole derivatives containing Benzimidazole moiety has been ...elemental analysis and further screened for antimicrobial activity and antiprotozoal ... See full document
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SYNTHESIS OF SOME PYRIDINE, PYRIMIDINE AND CYCLOHEXENONE DERIVATIVES AS ANTIBACTERIAL AGENTS
... e pyrimidine and related pyrimidines are classes of fused heterocycles that are of considerable interest because of the diverse range of their biological ... See full document
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SYNTHESIS AND ANTI-MICROBIAL ACTIVITY OF SOME NEW PYRIMIDINE DERIVATIVES
... with pyrimidine structures are known to possess antimicrobial 1,2 anti- inflammatory 3 , cytotoxic, 4,5 anti-cancer activities 6,7 ...study some new pyrimidine derivatives (1 to 5) have been ... See full document
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