[PDF] Top 20 Decreased force enhancement in skeletal muscle sarcomeres with a deletion in titin
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Decreased force enhancement in skeletal muscle sarcomeres with a deletion in titin
... which titin becomes up to four times stiffer in an actively stretched sarcomere (Leonard and Herzog, 2010; Powers et ...of titin force is elicited by titin binding to the thin ...residual ... See full document
6
Titin force enhancement following active stretch of skinned skeletal muscle fibres
... stretched skeletal muscle sarcomeres, titin-based force is enhanced, increasing the stiffness of active ...sarcomeres. Titin force enhancement in ... See full document
9
Titin force is enhanced in actively stretched skeletal muscle
... enhanced force of titin confirmed in the mouse skeletal muscle, future experiments can utilize the mdm model to further investigate the role of N2A titin in titin-based ... See full document
8
The role of titin in eccentric muscle contraction
... spring titin as a likely candidate for this ...intuitive. Titin is a long filament that spans half- sarcomeres inserting into the Z-band at one end and the M-line at the other end ...1997). ... See full document
9
Optimal length, calcium sensitivity and twitch characteristics of skeletal muscles from mdm mice with a deletion in N2A titin
... active force of mdm ...and decreased rate of force development in twitch ...small deletion in titin associated with mdm in skeletal muscles alters force production, ... See full document
12
Differences in titin segmental elongation between passive and active stretch in skeletal muscle
... passive sarcomeres was also approximately zero, suggesting that the F146 epitope and distal I-band titin are often located at the A-band edge ...with muscle shortening resulting from activation, ... See full document
8
Energy cost of isometric force production after active shortening in skinned muscle fibres
... isometric force after active stretching is enhanced compared with the corresponding purely isometric reference contractions (Abbott and Aubert, 1952; Edman et ...residual force enhancement. The ... See full document
7
Force enhancement in single skeletal muscle fibres on the ascending limb of the force–length relationship
... Therefore, force enhancement has been associated frequently with the occurrence of instability and the associated non-uniformities in sarcomere lengths (Julian and Morgan, 1979a,b; Edman et ...theory, ... See full document
5
Characterization of the passive component of force enhancement following active stretching of skeletal muscle
... for titin to contribute to the force enhancement, as observed here, titin’s stiffness, or its characteristic length, would need to change for actively stretching muscle compared to ... See full document
9
Deletion of the Ste20-like kinase SLK in skeletal muscle results in a progressive myopathy and muscle weakness
... ECM. Deletion or mutations in costamere-associated proteins result in an increase in central nuclei, decreased force generation and, in some cases, ...SLK deletion might affect a subset of ... See full document
13
Unraveling the Pathway of Lipid Oxidation in the Young Pig: Assessment of Hepatic beta-oxidation and Characterization of Carnitine Palmitoyltransferase I (CPT I)
... In skeletal muscle, the effects of a high fat diet on CPT I inhibition are less pronounced, and only apparent after prolonged consumption of a high fat diet (Power and Newsholme, ...and muscle ... See full document
146
The mitochondrial calcium uniporter underlies metabolic fuel preference in skeletal muscle
... Under these acute conditions, Mcu-deleted mice showed a significant defect in performance on the treadmill, presumably because they were not able to rapidly augment mitochondrial fatty acid and glucose oxidation, yet ... See full document
13
Glucocorticoid induced alterations in titin, nebulin, myosin heavy chain isoform content and viscoelastic properties of rat skeletal muscle
... of skeletal muscle are associ- ated with a complex network of cytoskeletal proteins where titin and nebulin play a substantial ...of muscle viscoelastic properties is widely accepted in ... See full document
6
Effect of exercise training on neuromuscular function of elbow flexors and knee extensors of type 2 diabetic patients
... Segerström AB, Elgzyri T, Eriksson K-F, Groop L, Thorsson O, Wollmer P. Exercise capacity in relation to body fat distribution and muscle fibre distribution in elderly male subjects with impaired glucose ... See full document
35
Murine Fig4 is dispensable for muscle development but required for muscle function
... specific force production; (2) loss of Fig4 does not alter the structure, EC coupling apparatus or bidirectional DHPR–RyR1 coupling; and (3) reexpression of Fig4 in neurons significantly reduces all observed ... See full document
12
Thoracic spine compression fractures following a snowboarding accident: a case study
... of muscle mechanics, we have begun to study questions of sarcomere stability and sarcomere length non-uniformity on the descending limb of the force- length ...all sarcomeres are stretched, and that, ... See full document
9
Deletion of the microtubule-associated protein 6 (MAP6) results in skeletal muscle dysfunction
... gastrocnemius muscle of anesthetized mice (6 WT and 7 MAP6 KO male mice, 7 to 8 months old) using a totally non-invasive procedure [39, ...value. Muscle contractions were induced by transcutaneous ... See full document
14
Severe thermoregulatory deficiencies in mice with a deletion in the titin gene TTN
... a missing allele from the sls gene, had 17% lower mitochondrial state 3 and 18% higher state 4 rates than controls. These results reveal that sls is a novel gene hub for regulation of mitochondrial respiration and that ... See full document
8
Molecular forces involved in force generation during skeletal muscle contraction
... in force generation, it should be useful in further modelling of the molecular events that occur during actomyosin interaction and in elucidating the mechanism of force generation by ... See full document
7
Assessment of Human Skeletal Muscle Contraction and Force by Diffusion Tensor Imaging
... the skeletal muscle movements, contractions in which they actively shorten and exert force to the outside world are called concentric ...between muscle contraction and tension resulting from ... See full document
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