[PDF] Top 20 Defect in messenger RNA for human hemoglobin synthesis in beta thalassemia
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Defect in messenger RNA for human hemoglobin synthesis in beta thalassemia
... homozygous beta thalassemia and sickle cell anemia. The messenger RNA stimulated the synthesis of human globin chains by a cell-free system derived from Krebs mouse ascites ...of ... See full document
7
Posttranscriptional defects in beta globin messenger RNA metabolism in beta thalassemia: abnormal accumulation of beta messenger RNA precursor sequences
... the beta-mRNA ...the beta-globin gene, accumulation of large 3H beta-intron RNA and beta- globin [3H]mRNA was normal in nuclei, but the ratio of beta/alpha [3H]mRNA in cytoplasm ... See full document
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Hemoglobin Messenger RNA from Human Bone Marrow ISOLATION AND TRANSLATION IN HOMOZYGOUS AND HETEROZYGOUS β THALASSEMIA
... relative synthesis of alpha to beta chains in response to normal hemoglobin mRNA was found to be a function of the amount of mRNA added to the assay system: increasing the amount of mRNA led to a ... See full document
12
α Thalassemia in the American Negro
... normal hemoglobin is decreased relative to that of b-chain in ...b-chain synthesis were determined in members of three Negro families with ...with hemoglobin H disease and a-thalassemia trait, ... See full document
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Beta-thalassemia
... with thalassemia intermedia is symptomatic ...with thalassemia intermedia have a high risk of thrombosis, exacerbated by splenectomy, it is important to be aware of thrombotic ... See full document
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Benefits of chronic blood transfusion in hemoglobin E/β thalassemia with pulmonary arterial hypertension
... After the physician advised patients that they may gain some benefit from chronic blood transfusions; patients were classified into one of two groups according to their preference. Group 1 patients were those with a ... See full document
6
Inhibition of endoplasmic reticulum-to-Golgi traffic by poliovirus protein 3A: genetic and ultrastructural analysis.
... inhibitor of glycoprotein synthesis, suggested a possible re- quirement for glycosylation of 3A-containing proteins in po- liovirus genome replication (18). Such a glycosylation event would argue that these ... See full document
11
Differing erythrocyte membrane skeletal protein defects in alpha and beta thalassemia
... alpha thalassemia (HbH disease), in patients with beta thalassemia intermedia, and in normal ...and beta-thalassemic spectrin functions normally in spectrin self-association, binding to normal ... See full document
8
Globin synthesis in fractionated Normoblasts of beta thalassemia heterozygotes
... the hemoglobin fraction obtained by gel filtration remained constant throughout maturation at an average of ...balanced synthesis at any stage of red cell development and excludes the possibility that total ... See full document
13
An insight to HTLV 1 associated myelopathy/tropical spastic paraparesis (HAM/TSP) pathogenesis; evidence from high throughput data integration and meta analysis
... A significant increase was observed in the expression of PSMB8 in patients with HAM/TSP in comparison to those who carry the virus and normal subjects. PSMB8 is one of the 17 subunits essential for the synthesis ... See full document
11
Killing The Messenger: Exploring Novel Triggers For Messenger Rna Decay In Eukaryotes
... of messenger RNAs is regulated by multiple layers beyond their primary ...protein synthesis, mRNAs are decorated with RNA binding proteins, marked with covalent chemical modifications, and fold into ... See full document
230
Control of protein synthesis in Semliki forest virus-infected cells.
... The viral structural proteins were detectable with certainty at 3.5 h postinfection, and their rate of synthesis increased linearly parallel to the amount of their messenger, the 26S RNA[r] ... See full document
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Up-regulation of circ_LARP4 suppresses cell proliferation and migration in ovarian cancer by regulating miR-513b-5p/LARP4 axis
... LARP4 gene existed in some protists and all animals tested, while not in plants and yeasts [18]. LARP4 of mammal, which was also called LARP4A, had close inter- action with poly (A) RNA. It indicated that LARP4 ... See full document
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Genotype–phenotype correlation among beta-thalassemia and beta-thalassemia/HbE disease in Thai children: predictable clinical spectrum using genotypic analysis
... causing beta-thalassemia along with a geno- type–phenotype correlation in a Thai pediatrics ...population. Beta-thalassemia/HbE is the major thalassemia problem in Thailand and can be ... See full document
7
Myosin heavy chain messenger RNA and protein isoform transitions during cardiac hypertrophy Interaction between hemodynamic and thyroid hormone induced signals
... the beta-MHC mRNA followed by the appearance of comparable levels of the beta-MHC protein in parallel to an increase in the left ventricular ...of beta-MHC and induction of alpha-MHC, both at the ... See full document
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A RETROSPECTIVE STUDY ON THALASSEMIA IN SOUTH INDIAN TERTIARY CARE TEACHING HOSPITALJ.Lavanya*, S. Arshiya Banu, A.Lokesh, S. Asadulla2, M. Venkata SubbaiahDOWNLOAD/VIEW
... the hemoglobin moiety of the ...In thalassemia the rate of destruction of RBC is so rapid that it exceeds the liver capacity to metabolize the excess ...billirubin. Thalassemia is a major health ... See full document
5
Sex steroid hormone regulation of follicle stimulating hormone subunit messenger ribonucleic acid (mRNA) levels in the rat
... (FSH) beta, luteinizing hormone (LH) beta, and alpha subunit messenger RNA (mRNA) levels were examined in rats after castration and sex-steroid ...FSH beta genomic DNA, and alpha and LH ... See full document
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EFFICACY OF HEMOGLOBIN LEVEL IN DIAGNOSING OF BETA THALASSEMIA
... A study done among Sicily population which is an endemic area for thalassemia involving 23,485 samples from year of 2000 to 2006 found that 16.75% of the samples showed borderline HbA2 level, defined between 3.1- ... See full document
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In Patients with Minor Beta-Thalassemia, Cognitive Performance Is Related to Length of Education, But not to Minor Beta-Thalassemia or Hemoglobin Levels
... Individuals with known minor beta-thalassemia undergoing risk-analysis for marriage were asked to participate in the study. A total of 41 people was approached and 25 (61%) agreed to participate. Inclusion ... See full document
7
Instability of beta E messenger RNA during erythroid cell maturation in hemoglobin E homozygotes
... with beta-thalassemia to produce a disorder of variable severity that is the most common form of symptomatic thalassemia in Southeast ...The beta E-globin gene acts as a mild ... See full document
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