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[PDF] Top 20 A BRCA1 deficient, NFκB driven immune signal predicts good outcome in triple negative breast cancer

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A BRCA1 deficient, NFκB driven immune signal predicts good outcome in triple negative breast cancer

A BRCA1 deficient, NFκB driven immune signal predicts good outcome in triple negative breast cancer

... in outcome of patients with TNBC where some patients do very poorly, relapse and die within the first 3 years while patients who do not recur within this period tend to have a much better prognosis ... See full document

13

The Correlation Between PARP1 and BRCA1 in AR Positive Triple-negative Breast Cancer

The Correlation Between PARP1 and BRCA1 in AR Positive Triple-negative Breast Cancer

... cellular signal pathways including DNA replication, transcription, chromatin remodeling, telomere integrity, cell survival and death ...which BRCA1 has an important role [15-17]. As HRR pathway is impaired ... See full document

11

Increasing radiosensitivity by the combined inhibition of PARP1 and PI3K in BRCA1-mutated triple negative breast cancer

Increasing radiosensitivity by the combined inhibition of PARP1 and PI3K in BRCA1-mutated triple negative breast cancer

... in triple- negative breast cancer ...of BRCA1 deficient breast cancer cells to PARP1 ...inhibition. Cancer Lett, 319: 232- ... See full document

12

Prognostic significance of c-Met in breast cancer: a meta-analysis of 6010 cases

Prognostic significance of c-Met in breast cancer: a meta-analysis of 6010 cases

... lung cancer pa- tients [44]. The differences in the characteristics of breast cancer between Asian and Western countries have also been discussed for several years ... See full document

10

BRCA1 IRIS inactivation overcomes paclitaxel resistance in triple negative breast cancers

BRCA1 IRIS inactivation overcomes paclitaxel resistance in triple negative breast cancers

... Mechanistically, BRCA1-IRIS-dependent paclitaxel resistance could be mediated by pro-survival autocrine signaling loops, such as those shown here, namely EGF/EGFR-ErbB2 and ...with breast cancer [46] ... See full document

18

Investigation of a novel +ACA BRCA1 promoter polymorphism and its impact on the breast cancer susceptibility phenotype

Investigation of a novel +ACA BRCA1 promoter polymorphism and its impact on the breast cancer susceptibility phenotype

... in BRCA1 account for 40-50% of the BRCA1 expression loss in hereditary breast cancer (Couch, and Weber, ...of BRCA1 coding region genetic errors create frameshift or nonsense mutations ... See full document

147

Basal-like breast cancer: molecular profiles, clinical features and survival outcomes

Basal-like breast cancer: molecular profiles, clinical features and survival outcomes

... to cancer immune response, epithelial-mesenchymal transition and cell ...basal-like breast cancer ...basal-like breast cancers with distinct disease ... See full document

17

Systems biology analysis reveals NFAT5 as a novel biomarker and master regulator of inflammatory breast cancer

Systems biology analysis reveals NFAT5 as a novel biomarker and master regulator of inflammatory breast cancer

... The low prevalence of IBC, and the small size of diag- nostic biopsy specimens have been obstacles in under- standing of IBC pathogenesis. To date, current treatments are based on multimodal approaches, are non-specific ... See full document

13

A multigene predictor of metastatic outcome in early stage hormone receptor negative and triple negative breast cancer

A multigene predictor of metastatic outcome in early stage hormone receptor negative and triple negative breast cancer

... with breast cancer ...and cancer cell expression include EXOC7 (exocyst complex component 7) [38], ABO (blood group glycosylransferases A and B) [39], CLIC5 (chloride intra- cellular channel 5) [40], ... See full document

15

ADP-ribosylation factor 1 expression regulates epithelial- mesenchymal transition and predicts poor clinical outcome in triple-negative breast cancer

ADP-ribosylation factor 1 expression regulates epithelial- mesenchymal transition and predicts poor clinical outcome in triple-negative breast cancer

... and breast cancer of higher histological grades (Figure ...of breast cancer ...of breast cancer were ...B breast cancer had the lowest level of this ARF ...luminal ... See full document

17

MicroRNA deregulation in triple negative breast cancer reveals a role of miR-498 in regulating BRCA1 expression

MicroRNA deregulation in triple negative breast cancer reveals a role of miR-498 in regulating BRCA1 expression

... Since BRCA1 protein is predominantly expressed in the nucleus, nuclear protein extraction was ...Sciences). BRCA1 protein content was determined relative to HSP70/HSC70 protein ... See full document

12

Effect of statins on breast cancer recurrence and mortality: a review

Effect of statins on breast cancer recurrence and mortality: a review

... of breast cancer. Specifically, in various breast cancer cell lines, statins increase apoptosis and radiosensitivity, inhibit proliferation and invasion, and decrease the metastatic ... See full document

7

Original Article Plasma CAMK2A predicts chemotherapy resistance in metastatic triple negative breast cancer

Original Article Plasma CAMK2A predicts chemotherapy resistance in metastatic triple negative breast cancer

... Abstract: Background: Chemotherapy resistance is a great obstacle in effective treatment for metastatic triple nega- tive breast cancer (TNBC). The ability to predict chemotherapy response would ... See full document

14

Immunotherapeutic interventions of Triple Negative Breast Cancer

Immunotherapeutic interventions of Triple Negative Breast Cancer

... expressing cancer cells by internalizing and trafficking to the lyso- some ...bearing BRCA1/2-mutated TNBC ...most breast cancers and promotes metastases by mediating intercellular adhe- sion, ... See full document

19

Do signal transduction cascades influence survival in triple-negative breast cancer? A preliminary study

Do signal transduction cascades influence survival in triple-negative breast cancer? A preliminary study

... intracellular signal trans- duction pathways, regulating cell adhesion and prolifera- ...those signal transduction cascades could be the Notch1 pathway, which plays a role in normal breast ... See full document

7

The prevalence of BRCA1/2 mutations of triple-negative breast cancer patients in Xinjiang multiple ethnic region of China

The prevalence of BRCA1/2 mutations of triple-negative breast cancer patients in Xinjiang multiple ethnic region of China

... BRCA-associated breast cancer in China; all the studies involved mainly ethnic Han ...the BRCA1/2 germline mutation was about ...three BRCA1 - and one BRCA2 -associated tu- mors were in ... See full document

5

Novel therapeutic strategies for patients with triple-negative breast cancer

Novel therapeutic strategies for patients with triple-negative breast cancer

... investigated that the histone deacetylase inhibitor, panobin- ostat (LBH589), was overtly toxic to TNBC cells in vitro due to G2/M cell cycle arrest and apoptosis, and decreased tumorigenesis in vivo and this was also an ... See full document

10

Original Article Expression of cleaved caspase-3 predicts good chemotherapy response but poor survival for patients with advanced primary triple-negative breast cancer

Original Article Expression of cleaved caspase-3 predicts good chemotherapy response but poor survival for patients with advanced primary triple-negative breast cancer

... primary triple-negative breast cancer ...E-cad negative group (N = 25; ...E-cad negative groups completed fewer second-line chemotherapy cycles (P = ...E-cad negative ... See full document

11

Gene expression molecular subtyping of triple negative breast cancer tumours: importance of immune response

Gene expression molecular subtyping of triple negative breast cancer tumours: importance of immune response

... Breast cancer heterogeneity makes it difficult to bring personalized medicine into the ...(IHC)-typed triple-negative (TN) tumours, which represent 12 to 17% of primary breast ... See full document

16

THE ROLE OF CHEMOTHERAPY IN TRIPLE NEGATIVE BREAST CANCER

THE ROLE OF CHEMOTHERAPY IN TRIPLE NEGATIVE BREAST CANCER

... Triple-negative breast cancers have a relapse pattern that is very different from hormone-positive breast cancers: the risk of relapse is much higher for the first 3–5 years but drops sharply ... See full document

5

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