[PDF] Top 20 Degeneration of the intervertebral disc

... Disc degeneration has proved a difficult entity to study; its definition is vague, with diffuse parameters that are not always easy to ...develop degeneration spontaneously [61,62] and of injury ... See full document

... of disc degeneration ...of degeneration in ...healthy disc (though small volumes such as might be used for testing growth factor or even cell therapy can obviously be ...bar ... See full document

... the intervertebral disc (IVD) is the most common cause of back-related disability among North American ...IVD degeneration, especially its biomolecular aspect, is poorly understood in an in vivo ... See full document

... severe disc degeneration, thus limiting the generalizability of our ...grade-5 disc degeneration, which has a hallmark fea- ture of a collapsed disc space, could have been driving the ... See full document

... Abstract: Intervertebral disc degeneration remains a pervasive and intractable disease arising from a combination of aging and stress on the back and ...the intervertebral disc, and the ... See full document

... pain, intervertebral disc degeneration (IDD) has attracted more and more attention of both investigators and ...physicians. Disc herniation, termed as intervertebral disc ... See full document

... The intervertebral disc (IVD) is composed of a central gel- atinous nucleus pulposus (NP), a peripherally located an- nulus fibrosus (AF), and the cranial and caudal cartilaginous endplates associated with ... See full document

... Disc degeneration is the most common cause of back pain in adults and has enormous socioeconomic ...moderate disc degeneration, where a potential for regeneration still ...the ... See full document

... The intervertebral disc is comprised of mechanically and structurally unique substructures including the annulus fibrosus and the nucleus pulposus, which function together to support and absorb the large ... See full document

... that intervertebral disc prolapse has ...herniated disc material with clinical ...vertebral disc compartments in the process of disc degeneration and ...observed disc ... See full document

... lumbar intervertebral disc degeneration and whether the association differs between field and administrative (non-field) ...lumbar intervertebral disc ...lumbar intervertebral ... See full document

... morphological degeneration according to previ- ously published criteria ...of degeneration within a disc: scores of 0 to 3 represent a histologically normal (non-degen- erate) disc; 4 to 6, ... See full document

... the intervertebral disc has been investigated by several groups, little attention has been paid to the subsequent physiological process and clearance of the apoptotic ...the disc were a vascularised ... See full document

... Background: Diabetes mellitus (DM) and low back pain which is mainly caused by degeneration of the intervertebral discs (IVDs) both are major public health problem worldwide. The present study was designed ... See full document

... different degeneration grades, and human and canine CLCs were silenced for caveolin-1 and/or supple- mented with caveolin-1 scaffolding domain (CSD) pep- tide in vitro to determine the (regenerative) effect of ... See full document

... of disc degeneration and radiographic disc height ...of disc ruptures with a significant structural ...segmental intervertebral instability and/or clinical symptoms using this CT-based ... See full document

... IVD degeneration and the cartilage changes in osteoarthritis, there has been relatively little inter- est in exploring the possibility that the disease processes involved in IVD degeneration might be driven ... See full document

... with degeneration, degen- erate IVDs show a much greater expression level of IL-1β than TNF-α and that, while the IL-1R1 was upregulated in degener- ation, the TNF receptor 1 (TNF-R1) was not ... See full document

... Telomere length is often considered a good indicator of the cell's replicative history [17]. Telomeres, however, can also be shortened during SIPS in a manner independent from replica- tion [18,23,24]. Thus, MTL can be ... See full document

... that disc cell senescence has an important role in the develop- ment and progression of IVD degeneration; thus, understand- ing the nature of cellular senescence will be paramount in devising new approaches ... See full document