[PDF] Top 20 <p>Co-Delivery of Docetaxel and Salinomycin to Target Both Breast Cancer Cells and Stem Cells by PLGA/TPGS Nanoparticles</p>

... specifically target to HeLa cells compared with C6-loaded NPs and C6-loaded ...cervical cancer treatment and the aptamer–polydopamine modification strategy could be a promising method for active ... See full document

... can target cancer cells and CSCs through a gelatinase- stimuli ...a delivery system for docetaxel or 5- fl ...the delivery of Sal to improve its solubility, which further ... See full document

... USA). Salinomycin, cou- marin 6, 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide (EDC), and N-hydroxysuccinimide (NHS) were purchased from Sigma-Aldrich (St Louis, MO, ... See full document

... of nanoparticles, evaluated by flow cytometry. Breast cancer cells were incubated with free CFPE, CFPE-Sali-NP, or CFPE-Sali-NP- her2 for 4 ...the cells for 30 min prior to treatment ... See full document

... efficient delivery system (Allen, 2002; Sapra and Allen, 2003; Zhang et ...study docetaxel loaded PLGA nanocarrier systems (PLGA nanoparticles, PLGA-PEG Nanoparticles and ... See full document

... Industry Co., Ltd. (Nanjing, China; purity, 98%). PLGA (acid terminated, lactide:glycolide, 50:50; molecular weight: 24,000–38,000 Da), TPGS, dimethyl sul- foxide (DMSO), EGF, basic fibroblast growth ... See full document

... metastatic breast cancer cells and can activate important transcriptional factors known as signal transducers and activators of transcription 3 ...various cancer cells have been ... See full document

... The in vivo antitumor efficacy of DTX-LPH was examined in SCC-7 tumor cell-bearing xenograft mice (Figure 8A). As shown, free DTX had limited influence on tumor growth, while DTX-LPH most effectively reduced tumor ... See full document

... 1,000. TPGS could improve drug permeability through cell membranes by inhibiting P-glycoprotein, and thus enhance absorption of drugs and reduce P-glycoprotein-mediated multidrug resis- tance in ... See full document

... Da, PLGA-PEG) was purchased from Polyscitech (Akina, IN, USA). Salinomycin, gefitinib, basic fibroblast growth factor (bFGF), and epidermal growth factor (EGF) were provided by Sigma- Aldrich ... See full document

... tumorigenic breast cancer cells has recently been ...These cells, known as breast-cancer stem-like cells (BCSC), express markers similar to mammary stem ... See full document

... − cells which were in close association with ...our co-culture comprising P- MSCs by a series of blocking experiments further under- scoring the supremacy and specificity of such ...that ... See full document

... 7RGHWHUPLQHWKHUROHRI+,)_ in proliferation, survival and dopaminergic differentiation in vitro, as well as survival of murine dopaminergic neurons in vivo+,)_ was conditionally inactivated ... See full document

... Figure 2: ADT sequentially alters the cancer stem-like cell populations and promotes EMT in TRAMP PCa tumors. (a) The protocol of TRAMP mice experiments was illustrated. TRAMP mice were castrated at ... See full document

... Fresh breast tissue samples were collected from Department of Breast Surgery, the First Affiliated Hospital of China Medical University between February 2010 and September 2011, including ductal carcinoma ... See full document

... MCF-7 cells and BCSCs was measured by an MTT assay. The MCF-7 cells and BCSCs were dissoci- ated and plated in a 96-well plate at 2,500 cells/well density in ...permit cells to attach to the ... See full document

... paclitaxel, docetaxel (DTX), gemcitabine or irinotecan, in concurrence with ...the delivery of anti-cancer ...redox-sensitive docetaxel prodrug (DTXp) was designed and used along with ... See full document

... Notes: (A) real-time Pcr analysis of mir-1 expression in breast cancer and normal tissues. (B) real-time Pcr analysis of eVi-1 expression in breast cancer and normal tissues. (C, D) Expression ... See full document

... These nanoparticles have the potential to be used for a wide variety of applications, so that improvements in the quality of the NPs are being investigated, and their use in the field of further application is ... See full document

... of cells from G1 to S phase and is overexpressed in up to 50% of human breast ...serving both upstream and downstream of the Wnt ...predicting breast cancer aggres- siveness and poor ... See full document