Top PDF Demographic determinants of syphilis seroprevalence among U S blood donors, 2011–2012

Demographic determinants of syphilis seroprevalence among U S  blood donors, 2011–2012

Demographic determinants of syphilis seroprevalence among U S blood donors, 2011–2012

Serological testing for syphilis was performed on all blood donations using a microhemagglutination assay (MHA-TP) (Beckman Coulter PK TP System, Fujirebio Diagnostics, Inc. Brea, CA) for IgG or IgM antibodies specific for T. pallidum . If the index sample tested react- ive, it was repeated in duplicate using the same MHA-TP assay that was employed for the initial screening. If either of the repeat samples tested reactive, the sample was la- beled as repeat reactive thereby prompting quarantine of the blood product and confirmatory testing. Confirmatory testing was performed using an enzyme immunoassay (EIA) (CAPTIA™ Syphilis (T. pallidum) – G, Trinity Bio- tech USA, Jamestown, NY). A confirmed positive test re- flects T. pallidum seropositivity, which includes both historical and active syphilis (treponemal screening lacks the ability to differentiate between historical vs. active syphilis infections). The samples that were confirmed as T. pallidum MHA seropositive were further tested using a quantitative rapid plasma reagin (qRPR) (ASI RPR Card Test for Syphilis, Manufacturer: Arlington Scientific, Inc., Springville, UT) and subsequently titered. For the purpose of this analysis, active syphilis infections were identified by samples reporting a reactive qRPR titer ≥ 1:8 dilution, con- sistent with previous studies of syphilis serology [13].
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Demographic profile of syphilis among blood donors at a tertiary care hospital

Demographic profile of syphilis among blood donors at a tertiary care hospital

A 5 year Retrospective study was carried out at Department of Blood Transfusion and Immunohaematology of Govt Medical College, Baroda from April 2012 to March 2017. Before donation each potential donor was made to fill a detailed health history questionnaire, which included data regarding age, gender, address, occupation and other questions concerning the donor’s general health, lifestyle and risk behaviour. All the donors were tested for syphilis using RPR test. Written informed consent was obtained from each donor.

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Seroprevalence and determinants of transfusion transmissible infections among voluntary blood donors in Homabay, Kisumu and Siaya counties in western Kenya

Seroprevalence and determinants of transfusion transmissible infections among voluntary blood donors in Homabay, Kisumu and Siaya counties in western Kenya

Using Yamane formula, and based on KNBTS selec- tion protocol, blood samples of 1215 voluntary blood donors aged 16–65  years from Homabay, Kisumu and Siaya counties (see Additional file  1), was determined for a cross-sectional study by random sampling. Labo- ratory tests were conducted at Kisumu Regional Blood Donor Center, Kenya, from November 2015 to October 2016 based on its proximity to study sites and quality standards available. Ethical approval was obtained from Maseno University Ethical Review Committee (MUERC). Blood donors were enrolled under informed written con- sent or with guardian consent in case of donors less than 18  years. A self administered pre-donation question- naire (see Additional file  2), was used to screen poten- tial donors for health fitness and to collect demographic
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Seroprevalence of Hepatitis E Virus infection among volunteer blood donors in central province of Iran in 2012.

Seroprevalence of Hepatitis E Virus infection among volunteer blood donors in central province of Iran in 2012.

In this study we investigated the seroprevalence of HEV infection among volunteer blood donors in Central province of Iran. Anti-HEV was detected in 14.3% of the cases. So the prevalence of anti- HEV in current study is higher than reported in previous studies from other parts of Iran (2, 21, 22, 30, 31) and in the range of other studies in the Middle East (36, 37). It can be due to differences in the demographics of studied population, the size of the samples, the public health services situation and used anti-HEV detection assays. Because HEV- RNA was not examined in our study, we cannot draw conclusions regarding active HEV prevalence in our blood donors. As both HEV epidemiology and cost effectiveness of a test are important in deciding whether adding a screening test to current blood product screening tests is appropriate or not, this topic merits further study.
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Seroprevalence and risk factors for HIV, HCV, HBV and syphilis among blood donors in Mali

Seroprevalence and risk factors for HIV, HCV, HBV and syphilis among blood donors in Mali

Risk factors associated with HIV, HBV and HCV infections Univariate and multivariate logistic regression analyses were performed to assess independent associations be- tween socio-demographic data and HIV, HBV or HCV infections. In univariate analysis, HIV was significantly associated with being married (odds ratio [OR], 1.57 [95%CI, 1.16–2.15], p = 0.016 ) and education level lower than secondary school (OR, 1.69 [95% CI, 1.28–2.25], p = 0.002 ). HIV also tended to be associated with greater age (OR, 1.01 [95%CI, 1.00–1.03], p = 0.06 ). In multivari- able analysis, HIV was only associated with education level (OR, 1.54 [95%CI, 1.15–2.07], p = 0.016 ). In univari- ate analysis, HBV-infection was significantly associated with being male (OR, 1.32 [95%CI, 1.10–1.59], p = 0.013 ) and this result was consistent in multivariable analysis (OR, 1.37 [95%CI, 1.14–1.66], p = 0.005 ) adjusting for age, education level, marital status and type of blood do- nation. Education level lower than secondary school was also associated with HBV in multivariable analysis (OR, 1.17 [95%CI, 1.05–1.31], p = 0.021 ). Living outside Bamako was the only factor associated with HCV in multivariable analysis adjusting for gender, age and edu- cation level (OR, 1.83 [95%CI, 1.41–2.35], p = 0.0001 ) (Table 3).
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Seroprevalence and risk factors on Syphilis among blood donors in Chengdu, China,from 2005 to 2017

Seroprevalence and risk factors on Syphilis among blood donors in Chengdu, China,from 2005 to 2017

Blood specimens from the blood donors were tested for HBsAg, anti-HCV, anti-HIV (types 1 and 2), syphilis, and ALT according to procedures stipulated in the Chengdu blood center. The equipment of anti-TP test- ing: FAME24/20 automatic enzyme immunoassay sys- tem (Hamilton, USA). Reagents: anti-TP diagnostic kit (Beijing Wantai, lot number N20110405, N20110708; Beijing Huada love, lot number 20110616, 20110915). Blood specimens were carried out using two different test kits that were approved by the Chinese Food and Drug Administration. Each donation was screened by two ELISA kits regardless of the result of the first one. Each initial reactive sample was further tested in dupli- cate, according to the manufacturer’s instructions. If two out of three results were positive (Repeat Reactive), the unit was discarded and the sample was classified as positive.
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Seroprevalence of Cytomegalovirus Infection in Blood Donors in Khorramabad

Seroprevalence of Cytomegalovirus Infection in Blood Donors in Khorramabad

Results: Out of 270 samples, 90% were males, and 10% were females. Anti-CMV IgG antibody was positive in 148 samples (55%), and negative in 122 ones (45%). Moreover, anti-CMV IgM antibody was negative in 269 cases (99.6%), and positive in 1 case (0.4%). Conclusion: Considering the high seroprevalence of anti-CMV antibody in Khorramabad, latency of the virus inside the blood cells, and its possible transmission via blood and blood products to blood receivers particularly in immunodeficient patients including those with malignant diseases receiving chemotherapy and recipients of allograft transplants, performing screening tests on donated blood samples for CMV infection particularly in high risk cases is recommended.
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Seroprevalence and risk factors of hepatitis B virus among blood donors in district Charsadda Khyber Pakhtunkhwa Pakistan

Seroprevalence and risk factors of hepatitis B virus among blood donors in district Charsadda Khyber Pakhtunkhwa Pakistan

blood donors of district Charsadda, Khyber Pakhtunkhwa Pakistan. All the blood donors included in this study were males because the majority of females in Pakistan do not donate blood due to traditions, especially in Khyber Pakhtunkhwa. The seroprevalence of HBV in our study was (2.60%) which was quite similar to the prevalence of HBV among blood donors in Peshawar (2.68%) [21] and Bahawalpur (2.69%) [22].While it was lower than the prevalence reported from some other regions of the country including (6.2%) in Interior Sindh [22], (5.86%) in Rawalpindi [23] and (5.81%) in Thatta [24].Where it was higher when compared with data reported from some other cities of the country including Lahore (1.52%) [25] and Abbottabad (1.55%) [26].
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Seroprevalence of Cytomegalovirus among Blood Donors at Omdurman Teaching Hospital, Omdurman, Sudan

Seroprevalence of Cytomegalovirus among Blood Donors at Omdurman Teaching Hospital, Omdurman, Sudan

All of the ninety (90) healthy individuals selected for blood donation were males. The mean age of the individuals was 26.7 years (age range 18-50 years). Seropositivity was 82 (91.1%) and 12 (13.3 %) for CMV-IgG and CMV-IgM antibodies respectively. There was no statistically significant difference (p > 0.05) in the CMV IgG status in different age group. The result showed highest seroprevalence (37.8% for IgG) among age group (25-31 year) - Table.1

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Seroprevalence of transfusion transmitted infections among blood donors in sms hospital jaipur: a cross sectional study

Seroprevalence of transfusion transmitted infections among blood donors in sms hospital jaipur: a cross sectional study

Since more males qualified following the criteria of fitness and a higher proportion of males came for voluntary donations, especially in camps. During donor screening deferral rate of females was higher than male because of anaemia, deferral during menstruation and other fitness issues like lactation etc. Overall seroprevalence of TTI in study population reported was 1.56%.Seroprevalence of HIV, HBsAg, HCV, Syphilis was 0.085%,1.25%,0.07%, 0.15% respectively. Prevalence of infections (HIV, HBsAg, HCV, Syphilis) in present study among replacement donors were 0.07%, 0.94%, 0.05%, 0.09% respectively while in that of voluntary donors were 0.013%, 0.30%, 0.19% ,0.059% respectively but this difference is statistically not significant (P=0.531).Studies like Makroo RN et al (12) , Jain R et al (18) have shown high seropositivity rates of TTI in replacement donors compared to voluntary donors, a similar finding was noted in present study. The risk of having TTIs in the replacement donors was 2 to 2.5 times more when compared with the voluntary donors. This emphasizes the importance of repeat, non- remunerated, regular voluntary donations. The discrepancy of TTI seropositivity in replacement/relative versus voluntary donors in various studies including present study may be due to the large number of replacement/ relative donors compared to the voluntary donors. Lack of knowledge about TTI probably accounted for high infection in replacement blood donors.
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SEROPREVALENCE OF TOXOPLASMA GONDII AND ASSOCIATED RISK FACTORS AMONG BLOOD DONORS AT GONDAR UNIVERSITY HOSPITAL, NORTHWEST ETHIOPIA

SEROPREVALENCE OF TOXOPLASMA GONDII AND ASSOCIATED RISK FACTORS AMONG BLOOD DONORS AT GONDAR UNIVERSITY HOSPITAL, NORTHWEST ETHIOPIA

Among the risk factors that are found to be significantly associated in the Bivairate analysis, only habit of handling cat excreta, habit of eating uncooked meat and habit of eating raw vegetables and fruits were found to be significantly associated with T. gondii positivity in multiple logistic regression analysis. Those blood donors who had a habit handling cat excreta found almost 5.6 times (AOR=5.683, 95%CI= 3.390, 9.527) more likely to be sero positive than those who did not handle cat excreta and blood donors who eat uncooked meat found almost 1.3 times (AOR=1.291, 95%CI= 1.092, 3.578) more likely to be sero positive than those who do not eat.
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Q fever in humans and farm animals in four European countries, 1982 to 2010

Q fever in humans and farm animals in four European countries, 1982 to 2010

In the Netherlands, the capability for diagnosis of human Q fever had increased substantially in 2008 and 2009, as compared to 2007, the first year of the epidemic [14,16]. Increasing familiarity with the pres- entation of Q fever in people resulted in more-rapid diagnosis of clinical cases and a lower percentage of hospital admissions. The government-funded Q fever network in Germany [45] was able to transfer diagnos- tic capability, including cultivation techniques, to two human medical laboratories to address an important gap in diagnostic capability. This network was initi- ated to promote epidemiological work to identify the risks of Q fever for public health, to develop reason- able counter-measures, to conduct basic research and to raise public awareness. The network relies on a ‘One Health’ approach among physicians, veterinarians, epi- demiologists and software developers. Further, efforts have been made to increase case notification (both in humans and farm animals) and to increase awareness among medical doctors, veterinarians and the broader public, with greater emphasis on timely hospitalisation of patients and optimised medication to reduce life threatening sequelae. Case–control studies and inten- sive testing carried out during and after the outbreaks in France in 2002 [33] and 2007 [25], and in Bulgaria in 2004 [32], provided more detailed information on the status of affected areas and increased general aware- ness about the disease.
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Evaluation of Various Techniques for Sero Diagnosis  of Syphilis in Blood Donors

Evaluation of Various Techniques for Sero Diagnosis of Syphilis in Blood Donors

Syphilis, the first transfusion-transmitted disease described, was reported commonly before 1950. Screening of blood donors have been performed with serological test from the early of stages of blood transfusion practices.. Although the risk the transmission of syphilis through blood is negligible, in India, it is mandatory that blood banks screen every donation for syphilis 3 . The study was performed to evaluate the true seroprevalence of syphilis in blood donors as well as to evaluate the suitability of Immunochromatographic test, PaGIA, TPHA and ELISA as replacement for RPR either for screening or confirmation of syphilis in blood donors.
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Seroprevalence of transfusion transmissible viral infections (HIV, HBV and HCV) among voluntary blood donors at University of Gondar Comprehensive Specialized Hospital, Gondar; Northwest Ethiopia

Seroprevalence of transfusion transmissible viral infections (HIV, HBV and HCV) among voluntary blood donors at University of Gondar Comprehensive Specialized Hospital, Gondar; Northwest Ethiopia

A large percentage of the blood donors harbor transfusion- transmissible infections, 8.2% with at least one screened pathogen and 0.96% with multiple infections. The preva- lence of TTI infection high for all blood donors especially for age groups such as 20 – 29 and 30 – 39 years. Therefore, strict selection of blood donors with the emphasis on get- ting voluntary donors and highly sensitive and specific tests for screening of donorsblood for HIV, HBV, and HCV using standard methods are highly recommended to ensure the safety of blood for the recipient. The prevalence of HIV-HBV, HIV-HCV, and HBV-HCV co-infection need to be studied on a larger scale for a better understanding of the impact on clinical condition and treatment response.
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Seroprevalence of hepatitis C virus among blood donors attending Omdurman teaching hospital

Seroprevalence of hepatitis C virus among blood donors attending Omdurman teaching hospital

HCV is a blood borne virus that is most efficiently transmitted through exposures to blood, such as transfusions or transplants from infected donors, inadvertent contamination of supplies shared among patients undergoing chronic hemodialysis or sharing of equipment among injection drug users, transmission of HCV may also occur through high-risk sex or through prenatal exposure and percutaneous exposures in the health care setting or exposure to an infected household contact (9) .

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Seroprevalence of hepatitis B virus among blood donors attending Omdurman teaching hospital

Seroprevalence of hepatitis B virus among blood donors attending Omdurman teaching hospital

Screening of blood and blood products for HBV was only introduced to blood banks throughout the country in 2002, before which, screening was only performed in a very few centers in the capital Khartoum, Vaccination for HBV was included as part of the extended program of immunization in 2005, Sudan was classified among the countries with high HBV endemicity of more than 8% (17) , seroprevalence ranging from as

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Seroprevalence of Hepatitis C Virus Infection among Blood Donors at Madhya Pradesh, India:  A Retrospective Study

Seroprevalence of Hepatitis C Virus Infection among Blood Donors at Madhya Pradesh, India: A Retrospective Study

Place of work: Present study was carried out at National AIDS Control Organization (NACO) supported blood banks and MPSACS (Madhya Pradesh State Aids Control Society) Bhopal, Madhya Pradesh, India. Donors were screened by trained personnel after satisfactory answering the donor’s questionnaire, their physical examination and hemoglobin (Hb %) estimation.

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Serological and Molecular Detection of Chikungunya Virus among Arthritis Patient in Khartoum State, Sudan Alafra A Awad 1, Abdel Rahim M El Hussein2 , Mohamed O. Mustafa 2, Isam M Elkhidir3 and Khalid A Enan 2

Serological and Molecular Detection of Chikungunya Virus among Arthritis Patient in Khartoum State, Sudan Alafra A Awad 1, Abdel Rahim M El Hussein2 , Mohamed O. Mustafa 2, Isam M Elkhidir3 and Khalid A Enan 2

Seroprevalence of CHIKV IgM positivity was (3.3%) where one male and two females were found positive out of 90 arthritis patients tested. This was higher than indicated by Ahmed et al (2016) in Khartoum State , these authors reported that no IgM antibodies was detected in arthritis patients (16) . While this

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Sero-prevalence of Anti- HCV among Yemenis Blood Donors Attending National Blood Transfusion and Research Centre in Sana'a: Yemen

Sero-prevalence of Anti- HCV among Yemenis Blood Donors Attending National Blood Transfusion and Research Centre in Sana'a: Yemen

Results: A total of 3606 blood donors were enrolled in this study, 1.6% of them were anti-HCV positive. Distributed as the following, 1.1%, 2.8%, 2.2%, 2.9%, 3.4%, 2.4% and 1.7% of anti-HCV antibody was among blood donors resident the capital city of Sana'a, Sana'a rural area, Taiz, Ibb, Dahmar, Amran and Almahwet governorate respectively. The prevalence rate of HCV was higher among Handicraft (1.8%). High HCV seropositivity were detected among the age group 36-45, the difference was found statistically insignificance.
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Demographic characteristics of transfusion transmitted infections among blood donors in China

Demographic characteristics of transfusion transmitted infections among blood donors in China

tested TTI negative, which was similar to the findings of other studies on the demographic characteristics associ- ated with TTIs in China [4, 5]. According to bivariate lo- gistic regression analyses, our findings indicated that age, previous donation history, marital status, occupation, and education were correlated with TTIs status. All the demo- graphic factors mentioned above were independent pre- dictors for TTIs. Specifically, younger blood donors who were married and repeat donors with high educational level were less likely to be infected with TTIs. Besides, do- nors who were teachers, civil servants, or medical workers were less susceptible to TTIs. Large floating populations, mainly workers and company staffs who are principally unmarried males, sexually active, and far from their fam- ilies are susceptible to TTIs [6].
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