[PDF] Top 20 Design, development and evaluation of hollow microspheres of Repaglinide

... floating hollow microsphere of Repaglinide was successfully prepared by emulsion diffusion ...the microspheres were ranges ...developed microspheres showed good in- vitro buoyancy, high ... See full document

... Prolonged retention in the upper GIT tract can greatly improve the oral bioavailability and their therapeutic outcome. The pH dependent solubility and stability level plays an important role in its absorption. ... See full document

... for design of new drug delivery systems, which will reduce or eliminate the fluctuating plasma / blood ...administration. Microspheres can encapsulate many types of drugs including small molecules, ... See full document

... The microspheres were prepared by the solvent evaporation method using polymers hydroxypropyl methylcellulose (HPMC) in fixed ratio and Ethyl cellulose in variant ...prepared microspheres were characterized ... See full document

... Microsphere formulations using Eudragit S100 as a carrier polymer were prepared using emulsion solvent evaporation technique. Desired quantity of Eudragit S100 polymer was dissolved in 10 ml of chloroform to form a ... See full document

... the design, development, and evaluation of ondansetron hydrochloride loaded polymeric mucoadhesive microspheres for intranasal delivery to avoid first-pass metabolism phenomenon in the liver ... See full document

... complex microspheres was significantly decreased with increase in the drug to polymer ...the development of mucoadhesive microspheres as a nasal drug delivery system and shows compatibility in ... See full document

... study hollow microsphere of Aceclofenac was prepared by emulsion– solvent diffusion method by using Eudragit RS100 and HPMC as a ...the hollow microsphere was found to be spherical by SEM study, small ... See full document

... on development of sustained release nicorandil microspheres using solvent evaporation method and to study the effect of method of preparation on physical properties and drug release profile of nicorandil ... See full document

... prepared microspheres, 50 mg of microspheres were accurately weighed and crushed inside a glass mortar and dispersed in 100 ml of hydrochloric acid buffer (pH ...in microspheres)/(total mass of ... See full document

... Oral route is the most preferred route having advantage of easy administration, handling, and patient convenience. Gastroretentive delivery systems are mainly designed for drugs having narrow absorption window. Such ... See full document

... Mucoadhesive microspheres of Repaglinide using various Mucoadhesive polymers designed for oral controlled ...release. Microspheres containing the Mucoadhesive polymer chitosan hydrochloride, with ... See full document

... Pulsatile drug delivery system (PDDS) is based on principle of rapid release of a certain amount of drug within short time period after a predetermined off- release period, lag time. 1 Such novel drug delivery has been ... See full document

... like hollow microspheres are designed to achieve a continuous delivery of drugs at probable and reproducible kinetics over an extended period of time in the ...levels. Hollow microspheres are ... See full document

... Repaglinide (RGE) (assigned purity, 99.8%) was a gift sample from M/S Torrent Pharmaceutical Ltd., Ahmedabad, India. Commercially available RGE (0.5 mg) tablets (Repalin, Cipla Pharmaceuticals Ltd., Mumbai) were ... See full document

... Transdermal drug delivery systems are topically administered medicaments in the form of patches that deliver drugs for systemic effects at a predetermined and controlled rate1.A transdermal drug delivery device, which ... See full document

... of repaglinide which is indicated only for type II Diabetes ...1990). Repaglinide is required for long period of time so that mucoadhesive sustained release formulation was developed (Asane GS et ... See full document

... Pharmacosomes are amphiphilic lipid vesicular systems containing phospholipid complexes with a potential to improve bioavailability of poorly water soluble as well as poorly lipophilic drugs. To improve the water ... See full document

... From the results obtained with sodium hydroxide which is much less toxic than hydrochloric and sulphuric acids. It can be concluded that, NaOH is a favorable agent in attaching hydroxyl groups on the surface of HGMs for ... See full document

... Polymeric drug delivery system exhibit several advantages over the conventional dosage forms and it includes enhanced efficacy, patient compliance, reduced toxicity, and also to control the encapsulated drug release. ... See full document