[PDF] Top 20 Design, Synthesis, Characterization and Biological Evaluation of Some Novel 3, 4-Dihydropyrimidin-2(1h)-One as Anti Tubercular Agents.
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Design, Synthesis, Characterization and Biological Evaluation of Some Novel 3, 4-Dihydropyrimidin-2(1h)-One as Anti Tubercular Agents.
... for 2 to 12 weeks; the microorganisms continue to grow until they reach sufficient numbers to fully elicit the cell-mediated immune response, which can be detected by a skin ... See full document
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Design, Synthesis, Characterization and Biological Evaluation of Some Novel Pyridine Derivatives as Anti-Tubercular Agents against INHA
... “DESIGN, SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL EVALUATION OF SOME NOVEL PYRIDINE DERIVATIVES AS ANTI-TUBERCULAR AGENTS AGAINST ... See full document
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Design Synthesis Characterization and Biological Evaluation of Some Novel Benzothiazole Derivatives as Anti Tubercular Agents Targeting Glutamine Synthetase 1
... “DESIGN, SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL EVALUATION OF SOME NOVEL BENZOTHIAZOLE DERIVATIVES AS ANTI-TUBERCULAR AGENTS TARGETING GLUTAMINE ... See full document
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Design, Synthesis, Characterization and Biological Evaluation of Some Novel Benzimidazole (Schiff’ Base) Derivatives as Anti-Tubercular Agents against INHA
... TB was first discovered by Robert Koch in 1882. Robert Koch received the Nobel Prize in physiology or medicine for this discovery in 1905; The Bacterium is also known as "Koch's Bacillus". [6] Tuberculosis is the ... See full document
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DESIGN, SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL EVALUATION OF NOVEL ANTI TUBERCULAR AGENTS TARGETING GLUTAMINE SYNTHETASE 1 AND CYCLOPROPANEMYCOLIC ACID SYNTHASE 2
... They also have three metal ions in the active site between the two pockets, which are necessary for stability and catalytic activity. The amino-acid- binding site that is fairly well preserved amongst species, but the ... See full document
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Design, Synthesis, Characterization and Biological Evaluation of Some Novel Heterocyclic Derivatives as Anti Tubercular Agents Targeting L, D Transpeptidase 2
... 1, 3, 4-Oxadiazoles have also gained interest in medicinal chemistry as surrogates for carboxylic acids, esters and ...great biological potential and thus has made them important for molecule ... See full document
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Design, Synthesis, Characterization and Biological Evaluation of Novel Heterocyclic Derivatives as Anti-Tubuercular Agents
... CSP, 3 rd PDT ...good anti-tubercular activity. Based on the in-vitro anti- mycobacteial results, it is clear that the synthesized furan 2-yl derivatives exhibit remarkable activity ... See full document
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Design, synthesis and biological evaluation of some novel Schiff base derivatives as potential anticancer agents
... anticancer agents. The starting compounds,7-cyano-6-amino-N-(4-(un)substituted-phenyl)-2,3-dihydro-1H-pyrrolizine-5- carboxamides 17a–c, were reacted with different aldehydes to give the target compounds ... See full document
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Synthesis and Anti Convlsant Evaluation of Some Novel 4 Phenyl 6 Methyl 5 [(2' Substituted Phenyl) 1,3,4 Oxadiazole)] 3,4 Dihydropyrimidin 2(1h) One Derivatives
... is one possible reason for their activity ...antipyretic, anti-inflammatory, antipsoriasis agents. Some of them are active on the blood circulatory system and can stimulate the skin ... See full document
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SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL EVALUATION OF SOME NOVEL 1, 3, 4-TRISUBSTITUTED PYRAZOLYL CHALCONES FOR THEIR ANTIMICROBIAL AND ANTI-INFLAMMATORY ACTIVITIES
... Step 3: Synthesis of 1, 3-substituted diphenyl-1H- pyrazole-4 substituted phenylacrylamides: To a mixture of substituted acetanilides ...ethanol, 2% sodium hydroxide solution (1ml) was ... See full document
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SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL EVALUATION OF 4-(4-BROMO-1-HYDROXYNAPHTHALEN-2-YL)-6- ARYL-5,6-DIHYDROPYRIMIDIN-2(1H)-ONE
... 10. Rovnyak GC, Atwal KS, Hedberg A, Kimball SD, Moreland S, Gougoutas JZ, O’Reilly BC, Schwartz J, Malley MF. Basic 3-substituted-4-aryl-1,4-dihydropyrimidine-5- carboxylic acid esters. Potent ... See full document
5
DESIGN, SYNTHESIS, CHARACTERIZATION OF SUBSTITUTED 3-(BENZOTHIAZOLE)-2-(PHENYL)-THIAZOLIDIN-4-ONE HETEROCYCLIC COMPOUNDS AND ITS BIOLOGICAL EVALUATION
... thiazolidin-4- one heterocyclic compounds substituted with simple/fluoro benzothiazole scaffold at N 3 position, which is prepared from azomethine of benzothiazole by cyclo condensation with sulfanyl ... See full document
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Synthesis and biological evaluation of novel indole-2-one and 7-aza-2-oxindole derivatives as anti-inflammatory agents
... for 2 hours, then treated with LPS ...acid] 2 mM, Na 3 VO 4 200 mM, SDS [sodium dodecyl sulfate] ...at 4 ° C, the total protein was collected, and the concentrations were determined ... See full document
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DESIGN AND SYNTHESIS OF NOVEL 4 (4 FLUORO 3 METHYLPHENYL) 6 (SUBSTITUTED ARYL) 1,6 DIHYDROPYRIMIDIN 2 OL DERIVATIVES AS POTENT ANTI INFLAMMATORY AND ANALGESIC AGENTS
... of 4-(4-fluoro-3-methylphenyl)-6-(substituted aryl)-1,6- dihydropyrimidin-2-ol derivatives were synthesized and tested for their anti-inflammatory and analgesic ... See full document
6
Synthesis, Characterization and Biological Evaluation of Some 2-Azetidinones Derivative from Benzimidazole and Used as Anti-Fungicide Agents
... Benzimidazole derivatives are well-known biologically active N-containing heterocyclic [1], widely used as drugs such as proton pump inhibitor [2], antihelmenthetic, antidopaminergic [3], and antipsychotic ... See full document
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INSILICO DESIGN, SYNTHESIS AND CHARACTERIZATION OF SOME NOVEL BENZOTHIAZOLE DERIVATIVES AS ANTI CANCER AGENTS
... penetration, 2-medium penetration, 3-low penetration, and ...absorption, 2-poor absorption, and 3-very low ...solubility, 2-medium solubility, 3-low solubility, and ...4.0); ... See full document
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Design, One-pot Synthesis and Biological Evaluation of Imidazo[2,1-b] [1,3,4] Thiadiazole Derivatives for their Anti- Tubercular and Anti-Fungal Activity
... compound 3 with appropriate α-haloaryl ketones produce substituted imidazo thiadiazole derivatives ...the synthesis of designed molecules, a one-pot synthetic procedure was ...the one-pot ... See full document
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Insilico design, synthesis, characterization and biological evaluation of some novel 1 hydroxynapthelene 2 yl derivatives
... potent anti-inflammatory agents, novel series of napthyl chalcones were synthesized and their inhibitory effects on the bovine albumin and heat induced It was thought worthwhile ... See full document
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Synthesis, characterization and biological evaluation of novel 1,2,4-triazole derivatives as potent antibacterial and anti-inflammatory agents
... The Melting points were determined in open capillary tube and are uncorrected. Infra red spectra were recorded on Perkin Elmer spectrum spectrophotometer. 1 HNMR spectra were run on BRUCKER spectrometer (300MHz) using ... See full document
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Molecular Modelling, Synthesis, Characterization & Biological Evaluation Of Some Novel 2-Phenyl 3-Substituted Amino Quinazolin 4(3h)-Ones.
... based design. One approach is to dock or position ligand or receptor molecules together in many different possible ways and then scores each orientation according to an evaluation function of ... See full document
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