[PDF] Top 20 Design and Synthesis of Porphyrins for Targeted Molecular Brachytherapy
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Design and Synthesis of Porphyrins for Targeted Molecular Brachytherapy
... transferrin-labeled human serum albumin (HSA). Such a chemical structure was chosen because mammalian lysosomes contain enzyme activity which will remove the glucose to form an indoxyl. The indoxyl is soluble but very ... See full document
188
Design, synthesis, and evaluation of VEGFR-targeted macromolecular MRI contrast agent based on biotin–avidin-specific binding
... To link the antibodies to PDG, biotin–avidin reaction was employed in this study. Avidin is a kind of tetrameric glycoprotein with molecular weight of 60 kD. Avidin con- tains four identical subunits, each of ... See full document
14
Magnetic properties of a family of [MnIII4LnIII4] wheel complexes : an experimental and theoretical study
... The molecular approach to the synthesis of nanomagnets offers a wide range of possibilities to tailor the functionality of the fi nal compound, from the design of single-ion magnets, 1 − 3 to the ... See full document
11
In silico design and synthesis of targeted rutin derivatives as xanthine oxidase inhibitors
... Xanthine oxidase (XO) having molecular weight of around 300 kDa is oxidoreductase enzyme represented in the form of a homodimer. Both the monomers of XO are almost identical and each of them contains three domains ... See full document
13
Design, Synthesis, and Anti-Inflammatory Activity of Novel Quinazolines
... Several new fluorinated quinazolinone derivatives were prepared and evaluated for in vitro anti-inflammatory activity. The molecular modelling study was performed for compounds 4, 8, 9, 10 and 13. The tested ... See full document
10
Trends in targeted prostate brachytherapy: from multiparametric MRI to nanomolecular radiosensitizers
... control. Brachytherapy, a form of localized radiation therapy, has been shown to be one of the most effective methods for delivering high radiation doses to the cancer; however, recent evidence suggests that ... See full document
17
Ethyl 4 acetyl 3,5 dimethyl 1H pyrrole 2 carboxylate
... Data collection: CAD-4 Software (Enraf±Nonius, 1989); cell re®nement: CAD-4 Software; data reduction: HELENA (Spek, 2002); program(s) used to solve structure: SHELXS97 (Sheldrick, 1997); program(s) used to re®ne ... See full document
7
Synthesis and Invitro Anti-Cancer Evaluation of Some Novel 2, 3 Disubstituted Thiazolidinones
... Pharmaceutical Chemistry is an area of chemistry that deals with the structure, properties and reactions of compounds that contains carbon. Chemists in general and organic chemists in particular can create new molecules ... See full document
136
Metastatic sarcomatoid renal cell carcinoma to the mandible treated with Sorafenib
... units/day) was carried out after nephrectomy, but showed no marked effect on bone metastatic lesions. Therefore, the patient was administered a molecular targeted drug, Sorafenib (800 mg/day). Sorafenib ... See full document
6
Application of Central Composite Design for the Development and Evaluation of Chitosan-based Colon Targeted Microspheres and in vitro Characterization
... colon- targeted drug delivery systems include drug substances that treat colonic disorders such as ulcerative colitis, Crohn’s syndrome, and irritable bowel ... See full document
11
Solid Phase Synthesis of Modular Peptide-based Targeted Molecular Imaging Agents
... targeting molecular imaging agents ...organisms. Molecular imaging is a powerful tool that can detect the disease in the early onset which could save more ...specific molecular processes in diseased ... See full document
94
Identification of Parasitic Cysteine Protease Inhibitors using Analog Design, Molecular Docking and Molecular Dynamics Studies
... De novo designs process cannot give the approval that all designed analogues or compounds are feasible for chemical synthesis. As per reports, de novo designed molecules requires synthetic feasibility study of the ... See full document
15
A novel phantom design for brachytherapy quality assurance
... 2. Mesbahi A (2008) Radial dose func ons of GZP6 intracavitary brachytherapy 60Co sources: treatment planning system versus Monte Carlo calcula ons. Iran J Radiat Res, 5 (4): 181-6. ... See full document
6
<p>In silico Design and Synthesis of Tetrahydropyrimidinones and Tetrahydropyrimidinethiones as Potential Thymidylate Kinase Inhibitors Exerting Anti-TB Activity Against <em>Mycobacterium tuberculosis</em></p>
... the synthesis and the mycobacterial activity of several pyrimidinones and pyrimidinethiones as potential thymidylate kinase ...method. Molecular modeling was conducted using the Accelry ’ s Discovery Studio ... See full document
13
Design, synthesis and evaluation of VEGF-siRNA/CRS as a novel vector for gene delivery
... This work was supported by the National Natural Science Foundation (81502688), the Basic-Clinical Key Research Grant (16JL72) from Capital Medical University, the Impor- tation and Development of High-Caliber Talents ... See full document
15
Design and Characterization of Bilayer Tablet of Rifampicin and Isoniazid for Tuberculosis Therapy
... The aim in developing sustained or controlled delivery systems is to reduce the frequency of dosing and increases the effectiveness of the drug by specification at the site of action, and to providing the uniform drug ... See full document
5
Design synthesis and NMR studies of hybrid peptides
... We synthesized the α/β-hybrid peptide with proteinogenic side chains on the basis of the concept of alternating chirality using D Phe and β-amino acid, hVal by conventional solution phase synthesis using EDCI, DCC ... See full document
11
Molecular Design, Synthesis, Characterization and Biological Evaluation of 1-Substituted Tetrahydropyrimidine Derivatives by Leuckart Reaction.
... entitled“ MOLECULAR DESIGN, SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL EVALUATION OF 1-SUBSTITUED TETRAHYDROPYRIMIDINE DERIVATIVES BY LEUCKART REACTION” was done by ... See full document
165
Synthesis of meso Substituted ABCD Type Porphyrins by Functionalization Reactions
... General procedure for the synthesis of 5,10-AB–type porphyrins: A 250 mL Schlenk flask was charged with the porphyrin (1 equiv.) in 50 mL THF under Ar and cooled to –70 °C. The LiR reagent (hexylllithium, ... See full document
36
Synthesis and bioassay studies of cationic porphyrins for gene transfection delivery
... 34. Grand, C.L., Han, H., Munoz, R.M., Weitman, S., Von Hoff, D.D., Hurley, L.H. and Bearss, D.J. The Cationic Porphyrin TMPyP4 Down-Regulates c- MYC and Human Telomerase Reverse Transcriptase Expression and Inhibits ... See full document
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