[PDF] Top 20 Detection of R882 Mutations in DNMT3A Gene in Acute Myeloid Leukemia: A Method Comparison Study
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Detection of R882 Mutations in DNMT3A Gene in Acute Myeloid Leukemia: A Method Comparison Study
... the detection of DNMT3A R882 mutations were in line with those of previous studies (15, ...present study. Berenstein et al., performed a comparative study on various PCR-based ... See full document
9
Quantitative detection of DNMT3A R882H mutation in acute myeloid leukemia
... Somatic mutations in the DNA nucleotide methyltrans- ferase 3A gene ( DNMT3A) have been reported approxi- mately in 22 % of de novo acute myeloid leukemia (AML) and 36 % of ... See full document
11
Bisling, Kathrin (2017): Detection of DNMT3A R882 mutations in patients with acute myeloid leukaemia. Dissertation, LMU München: Medizinische Fakultät
... Acute myeloid leukaemia is a molecularly heterogeneous clonal disorder that has traditionally been stratified in three risk groups to predict patients’ ...detected. Mutations in the gene de ... See full document
82
<p>Genetic Characterization and Risk Stratification of Acute Myeloid Leukemia</p>
... TP53 mutations and loss of p53 function which resulting in genetic instability (Table ...(RPS14 gene) identi fi ed for the − 5q myelodysplastic ...ETS gene family: eg, ERG/ETS2 located on 21q, and ... See full document
23
The Philadelphia chromosome in leukemogenesis
... ABL1 protein, one of the non-receptor TKs, is present throughout hematopoietic development, with declining levels during myeloid maturation. The autophosphoryla- tion site in the activation loop of its SH1 domain ... See full document
15
GTPase regulator associated with the focal adhesion kinase (GRAF) transcript was down-regulated in patients with myeloid malignancies
... GRAF gene is located at chromo- some 5q31 and its protein is ubiquitously expressed in various tissues ...[9]. Mutations and deletions of GRAF gene were found in some cases with AML or myelodys- ... See full document
5
Detection of NPM1 exon 12 mutations and FLT3 – internal tandem duplications by high resolution melting analysis in normal karyotype acute myeloid leukemia
... NPM1 mutations in the de novo AML cases was 40% (12/29), consistent with the incidence reported in previous studies ...earlier study, where cytoplasmic localisation of NPM indicative of NPM1 ... See full document
5
A Morphological Study of Acute Myeloid Leukemia and Correlation With Clinical and Laboratory Findings, Including Results of Cytogenetic Analysis and Mutation Screening
... Hence, mutations in AML came to be grouped into two classes (42). The detection of more mutations subsequently led to the introduction of two more classes of mutations, based on the mechanism ... See full document
136
Mitogen-activated protein kinase binding protein 1 ( MAPKBP1 is an unfavorable prognostic biomarker in cytogenetically normal acute myeloid leukemia
... Briefly, gene expression and methylation data were obtained using Affymetrix Human Genome 133 plus ...2.0 Gene Chips, Human Genome U133A and HELP methylation ... See full document
11
Comparative examination of various PCR-based methods for DNMT3A and IDH1/2 mutations identification in acute myeloid leukemia
... analysed mutations in primary AML ...and DNMT3A mutations when no HRM-compatible real-time PCR cycler is ...IDH1 mutations, it was not possible to generate a valid method for analysing ... See full document
12
Landscape of gene fusions in epithelial cancers: seq and ye shall find
... ALL: Acute lymphoblastic leukemia; AML: Acute myeloid leukemia; APL: Acute promyelocytic leukemia, cholangio cholangiocarcinoma; CML: Chronic myeloid ... See full document
18
Current findings for recurring mutations in acute myeloid leukemia
... Although mutations of WT1 were first discovered in hematological malignancies more than a decade ago, the precise roles of WT1 in normal and malignant hemato- poiesis remain elusive ...and Leukemia Group B ... See full document
11
Original Article Double CEBPA mutations are prognostically favorable in non-M3 acute myeloid leukemia patients with wild-type NPM1 and FLT3-ITD
... CEBPA mutations on outcome has been extensively ...recent study has confirmed that survival of AML with dmCEBPA is similar with those with PML- RARA ...present study patients with dmCEPA harbored ... See full document
11
<p>High expression of dedicator of cytokinesis 1 adversely influences the prognosis of acute myeloid leukemia patients undergoing allogeneic hematopoietic stem cell transplantation</p>
... Acute myeloid leukemia (AML) is a malignant disease of hemopoietic stem ...while mutations in NPM1 bode a particularly better ...biallelic mutations of CEBPA is an independent factor ... See full document
8
The frequency of NPM1 mutations in childhood acute myeloid leukemia
... NPM1 mutations was available in 25/28 ...The study population included 1 patient with M0, 4 patients with M1, 4 patients with M2, 3 patients with M4, 5 patients with M5 (4M5a and 1M5b) and 1 patient with M6 ... See full document
5
CEBPA mutations in patients with de novo acute myeloid leukemia: data analysis in a Chinese population
... Although the frequencies of NPM1, FLT3-ITD, and c-kit were lower in patients with CEBPA mutations than those without, no significant difference was detected for any such mutation (each P.0.05). Compared with those ... See full document
5
Cancer stem cells in basic science and in translational oncology: can we translate into clinical application?
... are not affected. High-dose chemotherapy and novel tar- geted drugs may be able to eliminate the bulk of the neoplasm and to eradicate most CSC (or LSC) in a given tumor or leukemia. These debulking agents are ... See full document
21
Biological and clinical influences of <em>NPM1 </em>in acute myeloid leukemia patients with <em>DNMT3A</em> mutations
... of DNMT3A mutations should be considered as a poor-risk prognostic factor, irrespective of the NPM1 genotype as it may disturb the ...concerning DNMT3A mutations alone in AML patients together ... See full document
9
Clinical features of De Novo acute myeloid leukemia with concurrent DNMT3A, FLT3 and NPM1 mutations
... Categorical and continuous variables were analyzed using Pearson Chi-square and Kruskal-Wallis rank sum tests, respectively. Overall survival (OS) was estimated by the Kaplan-Meier method using as a reference time ... See full document
10
Downstream molecular pathways of FLT3 in the pathogenesis of acute myeloid leukemia: biology and therapeutic implications
... of acute myeloid leukemia (AML) patients have mutations of this gene, and such mutations are one of the most frequently identified types of genetic alterations in ...the ... See full document
10
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