[PDF] Top 20 Diabetic retinopathy: could the alpha-1 antitrypsin be a therapeutic option?

... cells could produce factors that induce the formation of tight junctions con- ferring barrier properties to the retinal vessels ...of diabetic retinopathy: vascular leakage and capillary ... See full document

... Abstract: Alpha 1 antitrypsin deficiency is a hereditary condition characterized by low alpha 1 proteinase inhibitor (also known as alpha 1 antitrypsin [AAT]) serum ... See full document

... Different conventional and newer diagnostic tools including glycated hemoglobin (HbA1c), thioredoxin- interacting protein, fructosamine, and glycated albumin have been used for detection of retinopathy in ... See full document

... it could improve the median motor nerve conduction velocity (MNCV) and sensory nerve conduction velocity (SNCV), peroneal MNCV, and SNCV after 14, 21, and 28 days of treatment and could reduce the Toronto ... See full document

... An earlier study by Cunha-Vaz et al. [20] observed that the degree of decrease in retinal fluid in the outer layers of retina is a more robust biomarker of BCVA recovery than central retinal thickness, disorganization of ... See full document

... of alpha 1AT of only 80 mg/dl protect the lung from an increased risk of ...of alpha 1AT by virtue of an inability of the Z-type alpha 1AT molecule to inhibit neutrophil elastase as effectively as ... See full document

... Diabetes Retinopathy Study (ETDRS) has staged NPDR with mild, moderate, and severe grades, aimed to screen risk factors and to detect the earlier stages of DR for nonsurgical treatment, eg, retinal ... See full document

... In order to identify the target proteins in the progress of HBV patients from mild to severe, one-milliliter of serum was collected from each patient of these two groups. The serum from mild and severe group were ... See full document

... We found interindividual differences in the electrophoretic A-1-AT patterns as well as quantitative differences in the concentrations of A-1-AT and the serum trypsin-inhibit[r] ... See full document

... Angiotensin II activates NADPH oxidase via AT 1 receptor activation in vascular cells. However, NADPH oxidase is probably not the only source of ROS stimulated by angio- tensin II. As we have reviewed, one ... See full document

... 'Abbreviations used in this paper: AAT, alpha-l-antitrypsin; COPD, chronic obstructive pulmonary disease; Pi, protease inhibitor; R3, R9, RR, total pulmonary resistance by oscillometric [r] ... See full document

... Notes: Genetic factors are proposed to play a central role in the pharmacological variation in response. evidences from linkage analysis and human leucocyte antigen (HLA) studies, genome-wide association analysis, and ... See full document

... (Hp), alpha-1-antitrypsin, apolipoprotein A-IV, serum paraoxonase and Zn-alpha-glycoprotein were increased and the proteins, clusterin precursor, alpha-2-macroglobulin, serum amyloid ... See full document

... with alpha 1-antitrypsin deficiency, who have decreased levels of serum alpha 1-antitrypsin and who have progressive panacinar ...homozygous alpha ... See full document

... Edematous diabetic Maculopathy is the leading cause of blindness in people under 60 in industrialized countries [1] [2] ...study, diabetic macular edema was more common in type I diabetics, as ... See full document

... CT angiography demonstrated a type B aortic dissection, extending from the left subclavian artery to the right superior femoral artery (Figures 1(a) and 1(c)). Visceral perfusion and renal perfusion were ... See full document

... et al. [46] conducted a multicentre family-based study in Europe and North America and included 2707 subjects. COPD probands had a smoking history of ⩾5 pack-years and had at least one sibling who had smoked for ⩾ 5 ... See full document

... In the present study and in previous investigations, trans- mission electron microscopy revealed elementary bodies as well as typical and aberrant reticular bodies, thus indicating active infection alongside persistent ... See full document

... whether it is comparable to human diab e tic reti- nopathy. In previous e fforts to study diabetic retinopathy in experimental animals, only two forms have been avail[r] ... See full document

... In order to explain the combination of the two phenom- ena observed in Mmalton, i.e. calcifications and lack of reactivity to the monoclonal ATZ11 antibody, we have in- ferred that Mmalton, among these three variants, is ... See full document