[PDF] Top 20 Different stages of B cell differentiation in non T acute lymphoblastic leukemia
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Different stages of B cell differentiation in non T acute lymphoblastic leukemia
... for B cell-related markers (BA-1 and B1 monoclonal antibodies, as well as cytoplasmic immunoglobulins [CyIg]) in the cALL cases showed that at least one B cell marker could be detected either ... See full document
9
MYC as therapeutic target in leukemia and lymphoma
... in different stages of the antigen- dependent B-cell differentiation ...antigen-dependent T-cell, the naïve B-cell moves to a fol- licle where it intensely ... See full document
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Profile of blinatumomab and its potential in the treatment of relapsed/refractory acute lymphoblastic leukemia
... cytotoxic T-cells to CD19+ target B-cells inducing serial perforin-mediated ...in non-Hodgkin’s lymphomas, but the most important trials have been conducted in relapsed/refractory (R/R) acute ... See full document
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The Role of PU.1 and Spi-B in B Cell Acute Lymphoblastic Leukemia
... in B-ALL in ...REH cell line will promote differentiation and change cell cycle status in the REH cell ...REH cell line could be validated in primary ETV6-RUNX1 patient ... See full document
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Childhood pre B cell acute lymphoblastic leukemia with translocation t(1;19)(q21 1;p13 3) and two additional chromosomal aberrations involving chromosomes 1, 6, and 13: a case report
... for different cell lineages and cell types: CD1a, CD2, CD3, CD4, CD5, CD8, CD10, CD11b, CD11c, CD13, CD14, CD15, CD16, CD19, CD20, CD22, CD23, CD32, CD33, CD34, CD38, CD41a, CD45, CD56, CD57, CD64, ... See full document
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<p>T-lymphoid/myeloid mixed phenotype acute leukemia and early T-cell precursor lymphoblastic leukemia similarities with <em>NOTCH1</em> mutation as a good prognostic factor</p>
... 10 T/M-MPAL cases were identi fi ed among 857 cases of childhood leukemia (T-ALL, n=266 and AML, n=591) before any treatment ...and T/M-MPAL, regarding the cellular expression of CD34, CD117, ... See full document
11
The molecular basis of T cell acute lymphoblastic leukemia
... mouse T cell progenitor cells confers self-renewal capacity to this normally non–self-renewing population ...stem cell properties and the oncogenic effects of LMO2 in T cell ... See full document
10
CTL019 (tisagenlecleucel): CAR-T therapy for relapsed and refractory B-cell acute lymphoblastic leukemia
... memory T-cell differentiation, in order to select the more efficient ...lymphocytes. T-cells exhibit clear differences in effector and proliferation function and it is the rationale behind the ... See full document
14
Acute B-Cell Lymphoblastic Leukemia/Acute B-Cell Lymphoblastic Lymphoma Presenting as Bilateral Breast Masses
... Hematologic metastases to the breast and axilla were rare occurrences. They usually develop in the fifth or sixth decade and the patients most often had a prior history of a malignant tumor with documented metastatic ... See full document
5
T cell receptor alpha , beta , and gamma genes in T cell and pre B cell acute lymphoblastic leukemia
... gamma-T cell receptor (TCR) gene activation within acute lymphoblastic leukemias (ALLs) that represent early stages of B and T cell ... See full document
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Case Report B-acute lymphoblastic leukemia occurring in two pediatric patients with a history of prior Wilms tumors
... on t-AL in the children with neuroblastoma? After treat- ment with similar chemotherapy, why does sec- ondary tumor occur in only a small portion rath- er than all of the patients? We speculate the answer might be ... See full document
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A high complex karyotype involving eleven chromosomes including three novel chromosomal aberrations and monoallelic loss of TP53 in case of follicular lymphoma transformed into B-cell lymphoblastic leukemia
... count of 156 × 10 9 /l. Biochemistry analyses revealed serum lactate dehydrogenase (LDH) value was 893.2 U/l (normal value up to 480 U/l); serum aspartate aminotrasferase (AST) level was 42 U/l (normal up to 45 U/l); and ... See full document
7
Induction of human B cell antigens in non T cell acute lymphoblastic leukemia
... four non-T cell ALL lines ...promyelocytic leukemia line or a T cell lymphoblastic leukemia ...on non-T cell ALL lines, cytoplasmic mu-heavy ... See full document
11
Targeting IRAK1 in T-Cell acute lymphoblastic leukemia
... T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematological malignancy resulting from the transformation of T-cell progenitors at various ... See full document
10
B cell origin of non T cell acute lymphoblastic leukemia A model for discrete stages of neoplastic and normal pre B cell differentiation
... all non-T cell ALLs tested, and given its absence on T cell and myeloid tumors, it appears to be an exceptional marker to define cells of B ...pre-B cell phenotypes ... See full document
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Prediction of outcomes by early treatment responses in childhood T-cell acute lymphoblastic leukemia: a retrospective study in China
... Results: The 5-year event free survival (EFS) and overall survival (OS) rates for these patients were 62.5 % (SE, 6.4) and 62.7 % (SE, 6.6), respectively. Prednisone poor responder was strongly associated with increased ... See full document
11
Emerging roles of epithelial-mesenchymal transition in hematological malignancies
... One of the major triggering events for EMT is the activa- tion of EMT-TFs, such as Snail1, Twist1, zinc finger E–box binding homeobox 1 (ZEB1), and ZEB2. These EMT-TFs often control the expression of each other and ... See full document
8
Impact of blinatumomab on patient outcomes in relapsed/refractory acute lymphoblastic leukemia: evidence to date
... with less tumor burden. Furthermore, using a flat dose of blinatumomab shortens the need for hospitalization for dose increases. There were a total of 113 patients evaluated for MRD response. MRD response was similar to ... See full document
9
Pediatric donor cell leukemia after allogeneic hematopoietic stem cell transplantation in AML patient from related donor
... with acute myeloid leukemia (AML) initially diagnosed as M5 and with karyotype ...stem cell transplantation, and six years later he relapsed as AML M1 with an abnormal karyotype ... See full document
7
WILMS' TUMOR GENE 1 (WT1) EXPRESSION IN CHILDHOOD ACUTE LYMPHOBLASTIC LEUKEMIA
... Subjects &Methods:An case-control study was conducted in pediatric Hematology & oncology unit ,zagazig university children's ٰ hospital ,zagazig university during the period of January 2011 to June 2013.we ... See full document
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