[PDF] Top 20 Direct selection on lifespan in Drosophila Melanogaster to elucidate the mechanisms of longevity

... the lifespan experiments necessitated removing as much age-independent mortality as ...the lifespan assays as well. Median lifespan was chosen as the selected measure because it better reflects ... See full document

... D. melanogaster, and ...regarding mechanisms of aging that may be applicable to ...and lifespan is the insulin / insulin-like signaling (IIS) pathway, which is involved in the regulation of ... See full document

... the mechanisms maintaining variation may vary from locus to ...stabilizing selection acting on Dl through its effect on bristle number, for which we have no direct ... See full document

... in Drosophila indicates that AOXs have originated from an ancient duplication of ...the Drosophila AOX genes are not directly related to the vertebrate ...D. melanogaster AOX genes, AOX1, AOX2 and ... See full document

... In each graph the bivariate distributions of all unselected flies have nearly the same slope and form a single long, narrow developmental zone, which must nearly sp[r] ... See full document

... The effects of relaxed selection on wing length, as shown in Figure 1 at different coefficients of inbreeding, indicate that relaxed selection at 25 percent coefficient of inbr[r] ... See full document

... The optomotor stimulation of the test flies in the selection machine is matched to the requirements of the visual system of Drosophila melanogaster Gotz, 1965 a, b; Hengstenberg & Gotz, [r] ... See full document

... D. melanogaster and starting date of the ...D. melanogaster for each replication was observed over a period of 4 weeks and the number of live flies was recorded in intervals twice a ... See full document

... fly, Drosophila melanogaster, as a model we examined the antioxidant properties of Murraya koenigii on the life history ...that Drosophila can be used to study the cellular, physiological and ... See full document

... CWO belongs to the basic helix-loop-helix-ORANGE (bHLH-O) transcription factor family. It is well known that in addition to cwo, 13 more basic helix-loop-helix- ORANGE family coding genes are present in the ... See full document

... polarity activity in Drosophila receptors (Wu et al. 2008). Also close to the end of TM7 and interleaved with the KTxxxW motif are two serine residues that have been iden- tified as potential protein kinase C (PKC) ... See full document

... Examination of Individual records of mortality In separate tubes, which are not given In the present paper, points on the whole to the conclusion that the Injurious influence of complete[r] ... See full document

... An analysis was made of longevity including the effects of mating status, sex, heterosis, iso- genic lines, general and specific combining ability, maternal ability, residual[r] ... See full document

... In addition we observed very little effect on the survival rate of dnc'14 females kept in the presence of many dead males or in vials with residues previously depos- ited by [r] ... See full document

... fly, Drosophila melanogaster, which displays high similarity to mammals with regards to alcohol related ...underlying mechanisms which may provide information to build new hypotheses to study ... See full document

... microbiota-dependent Drosophila traits (27, 28), indicating that bacterial effects on host TAG and development are neither limited to nor consistent within a specific taxonomic ... See full document

... of selection, the selected flies from each line (~300 individuals with approximately equal number of males and females) are divided into two groups of ~150 flies, each of which is placed into a bottle containing ... See full document

... both Drosophila-associated and human- administered probiotic strains protect Drosophila from infection provides a foundation for the use of the Drosophila system to study probiotic strains in a host ... See full document

... D. melanogaster helps to bridge a fundamental gap in therapeutic drug discovery in ...the direct inhibitors of crystallization is ...no direct crystallization inhibitors of uric acid nephrolithiasis ... See full document

... This study demonstrated that sublethal IMI exposure interferes with the Duox pathway in D. melanogaster. IMI-induced immunosuppression was observed by an increase in total bacteria and yeast, which has been ... See full document