[PDF] Top 20 Distinct p53, p53:LANA, and LANA Complexes in Kaposi's Sarcoma-Associated Herpesvirus Lymphomas
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Distinct p53, p53:LANA, and LANA Complexes in Kaposi's Sarcoma-Associated Herpesvirus Lymphomas
... activation, p53 is stabilized and induces cell cycle arrest or apoptosis through transcriptional activation of downstream targets (reviewed in reference ...30). p53 is among the most frequently mutated ... See full document
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Kaposi's Sarcoma-Associated Herpesvirus-Encoded LANA Recruits Topoisomerase IIβ for Latent DNA Replication of the Terminal Repeats
... aposi’s sarcoma-associated herpesvirus (KSHV), also called human herpesvirus 8 (HHV-8), is linked to Kaposi’s sarcoma, primary effusion lymphomas (PELs), and multicentric Castle- ... See full document
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A Potential α-Helix Motif in the Amino Terminus of LANA Encoded by Kaposi's Sarcoma-Associated Herpesvirus Is Critical for Nuclear Accumulation of HIF-1α in Normoxia
... of LANA can mediate HIF-1 ␣ accumulation that is independent of its SOCS-box ...by LANA coexpression but not HIF-1 ␣ alone, in- dicating that this accumulation is not dependent on VHL ...the ... See full document
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Differential Regulation of the Overlapping Kaposi's Sarcoma-Associated Herpesvirus vGCR (orf74) and LANA (orf73) Promoters
... proteins LANA (latency-associated nuclear antigen [also known as orf73]) and k-cyclin (orf72) similarly have been implicated in KSHV episome persistence and oncogenesis (2, 12, 14, 22, ...the LANA ... See full document
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The Single RBP-Jκ Site within the LANA Promoter Is Crucial for Establishing Kaposi's Sarcoma-Associated Herpesvirus Latency during Primary Infection
... 62). LANA is a multifunctional protein that regulates both transcription and cell ...growth. LANA regulates transcrip- tion through activating or repressing various cellular and viral promoters (1, 16, 23, ... See full document
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Brd2/RING3 Interacts with a Chromatin-Binding Domain in the Kaposi's Sarcoma-Associated Herpesvirus Latency-Associated Nuclear Antigen 1 (LANA-1) That Is Required for Multiple Functions of LANA-1
... of LANA-1 bound to LBS-1, whereas the more slowly migrating complex represents a tetramer of LANA-1 bound to both LBS-1 and LBS-2 in a cooperative fashion ...dimeric LANA-1/LBS-1 complex is formed ... See full document
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Kaposi's Sarcoma-Associated Herpesvirus-Encoded LANA Interacts with Host KAP1 To Facilitate Establishment of Viral Latency
... that LANA-recruited KAP1 is cru- cial for KSHV primary ...deacetylase complexes (32, ...with LANA, along with KAP1, are members of the deacetylase complex, such as HDAC1, HDAC2, and ...by LANA ... See full document
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Primary B Lymphocytes Infected with Kaposi's Sarcoma-Associated Herpesvirus Can Be Expanded In Vitro and Are Recognized by LANA-Specific CD4+ T Cells
... rKSHV.219 virus carries a puromycin resistance gene, we enriched for infected B cells by selection with puromycin. We found that the infected cells were very sensitive to puromycin, requiring low doses to enrich the ... See full document
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Identification of Host-Chromosome Binding Sites and Candidate Gene Targets for Kaposi's Sarcoma-Associated Herpesvirus LANA
... Kaposi’s sarcoma-associated herpesvirus (KSHV) genome to metaphase chromosomes and for modulating host-cell gene expression, but the binding sites in the host-chromosome remain ...use LANA- ... See full document
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Kaposi's Sarcoma-Associated Herpesvirus-Encoded LANA Can Interact with the Nuclear Mitotic Apparatus Protein To Regulate Genome Maintenance and Segregation
... forms complexes with dynein/dynactin and microtubules, which is critical for the seg- regation of replicated viral ...of LANA have different functions and can cooperate to tether the KSHV genome on human ... See full document
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H2AX Phosphorylation Is Important for LANA-Mediated Kaposi's Sarcoma-Associated Herpesvirus Episome Persistence
... of LANA was observed only in the pres- ence of the KSHV episome, and without the KSHV episome it showed a diffused staining, as expected ...and LANA. Reduction of LANA binding to TR under reduced ... See full document
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Distinct Biology of Kaposi’s Sarcoma-Associated Herpesvirus from Primary Lesions and Body Cavity Lymphomas
... Kaposi’s sarcoma (KS), a recurrent multifocal angioprolif- erative disorder, is the most common neoplasm in patients with AIDS (4, ...and herpesvirus saimiri, and the virus was proposed as a novel member of ... See full document
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In Vivo Persistence of Chimeric Virus after Substitution of the Kaposi's Sarcoma-Associated Herpesvirus LANA DNA Binding Domain with That of Murid Herpesvirus 4
... to distinct partners, which could affect transcription or FIG 5 Detection of LANA proteins in infected ...and LANA-expressing cells in spleens of infected C57 BL/6 mice (10 4 ... See full document
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Kaposi sarcoma–associated herpesvirus: immunobiology, oncogenesis, and therapy
... LANA-episome complexes adopt higher-order structures in the nucleus of infected cells and appear as a characteristic punctate pattern by immunofluorescence (114, 118, ...of LANA dots correlates with ... See full document
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Activated Nrf2 Interacts with Kaposi's Sarcoma-Associated Herpesvirus Latency Protein LANA-1 and Host Protein KAP1 To Mediate Global Lytic Gene Repression
... with LANA-1 and ORF50 re- pression (15, 16, ...that LANA-1-mediated KAP1 recruitment to the ORF50 promoter resulted in repressive epigenetic modifica- FIG 10 Analysis of Nrf2 and KAP1 knockdown effects on ... See full document
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Kaposi's Sarcoma-Associated Herpesvirus LANA2 Is a B-Cell-Specific Latent Viral Protein That Inhibits p53
... the distinct dispersal of the two proteins exclusive of each other, yellow nuclear staining is also evident in other areas, possibly representing colocalization of a subfraction of LANA1 and ... See full document
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Bub1 in Complex with LANA Recruits PCNA To Regulate Kaposi's Sarcoma-Associated Herpesvirus Latent Replication and DNA Translesion Synthesis
... aposi’s sarcoma-associated herpesvirus (KSHV) or human herpesvirus 8, an oncogenic member of the gammaherpesvi- rus subfamily, was first identified in 1994 from body cavity-based lymphoma ... See full document
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Kaposi’s Sarcoma-Associated Herpesvirus LANA-Adjacent Regions with Distinct Functions in Episome Segregation or Maintenance
... of LANA, suggesting selection for increased TR copy numbers for these cell lines ...adjacent LANA binding sites. C-terminal LANA forms multimers through dimer-dimer interactions (43–47), and it is ... See full document
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Latency-Associated Nuclear Antigen (LANA) of Kaposi's Sarcoma-Associated Herpesvirus Interacts with Origin Recognition Complexes at the LANA Binding Sequence within the Terminal Repeats
... 1, LANA and EBNA1 sequence analysis did not reveal the presence of any motif associated with enzymatic activities such as helicase or ATPase, which are essential for replication (6, 52, ...that LANA ... See full document
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Functional p53 Signaling in Kaposi's Sarcoma-Associated Herpesvirus Lymphomas: Implications for Therapy
... of p53 is sufficient to mediate the cell cycle arrest in PEL, we used a recently discovered chemical activator of p53, ...prevent p53 degradation (67, ...wild-type p53 (VG-1, BCLM, JSC-1, and ... See full document
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