[PDF] Top 20 DIVERSITY OF VOLTAGE GATED PROTON CHANNELS Deri Morgan and Thomas E. DeCoursey

... to voltage, with an open probability that increases with membrane ...by voltage-gated proton channels make them unique among ion ... See full document

... age-gated proton channels in human neutrophils (1–3, ...by voltage-clamping human ...reported proton currents in human cell lines (179, ...functional proton channels in ... See full document

... the channels can be ...the voltage pulse. The proton chan- nel does not close during sustained depolarizing pulses! Many voltage-gated ion channels (Na + , K + , Ca 2+ , Cl − ) ... See full document

... ion channels 16 are thought to contain a narrow pore through which a column of water molecules 17 interspersed with ions is obliged to march in single fi ...bare proton, hopping from one ligand to another ... See full document

... channel is a molecular entity distinct from any known NADPH oxidase component. Although much progress has been made, the most exciting discoveries lie in the future. I thank Vladimir V. Cherny for nearly a decade of ... See full document

... n channels in snail neurons have extremely rapid gating kinetics, opening and closing in a few ...o channels in newt oocytes and type e in epithelial cells gate more ...Type e channels ... See full document

... Chen, Y. H., Dale, T. J., Romanos, M. A., Whitaker, W. R. J., Xie, X. M. and Clare, J. J. (2000). Cloning, distribution and functional analysis of the type III sodium channel from human brain. Eur. J. Neurosci. 12, ... See full document

... the mechanism and put it in good working order in an environment suitable for its operation during t. Once everything is ready to go, the parts of the mechanism must stay connected to one another and retain a number of ... See full document

... express voltage-gated proton channels (1). Proton channels are opened by depolarization and/or cytoplas- mic acidification and seem to be designed for rapid, efficient acid ... See full document

... In some studies, green fluorescent protein (GFP)-tagged proton channels were studied. More often, GFP was co-transfected with the proton channel construct. Fluorescent cells were identified in the ... See full document

... atrophy during periods of disuse (e.g., immo- bilization), and this phenomenon is also present in the primary inspiratory muscle, the diaphragm, during MV. Unfortunately, the underlying mechanisms that produce skeletal ... See full document

... BK Channels Are Absent and Play No Functional Role The electrophysiology of the respiratory burst was re- examined in light of a recent study concluding that BK channels play an essential role in innate ... See full document

... fact that a single amino acid substitution converts a proton- specific channel to an anion-permeable channel in both species must, therefore, reflect an essential design feature of the proton channel. There ... See full document

... resolved, but usually was about double the unitary H current calculated at the same voltage from . It is possible that these events were simultaneous openings of multiple channels, and that the single ... See full document

... major voltage- gated sodium channels in human brain ...SCN8A voltage-gated sodium channel leads to decreased neuronal excitability which is related to changes in the firing patterns in ... See full document

... al. Voltage-gated sodium channel (Na-V) protein dissection creates a set of functional pore-only ...prokaryotic voltage-gated sodium ... See full document

... the membrane dipping loop between the 5th and 6th transmembrane segments of each domain (Fig. 1) (Catterall, 2000). There are nine a subunits, Na v 1.1-Na v 1.9, encoded by SCN1A-SCN11A (Catterall, 2000). The different a ... See full document

... 65. Lo WL, Donermeyer DL, Allen PM. A voltage-gated sodium channel is essential for the positive selection of CD4(+) T cells. Nature immunology 2012. 66. Andrikopoulos P, Baba A, Matsuda T, Djamgoz MB, ... See full document

... encoding voltage-gated sodium ...for voltage-gated sodium channels and provided new insights into the pathophysiological basis for common diseases such as cardiac arrhythmias and ... See full document

... The injection of cytoplasm, especially fraction P10 (see Fig. 2 and Materials and methods), from the wild-type cells into the pwA or pwB cells caused the mutants to regain the voltage-activated calcium conductance ... See full document