[PDF] Top 20 Dormancy in the stem cell niche

... like stem cells, retain the label over time and can be identifi ed as label-retaining cells (LRCs) ...dividing stem cells can be identifi ed through their ability to retain the label combined with the ... See full document

... Metastatic Niche(s)’ ...metastatic niche strongly inluences the fate of DTCs arriving in bone, driving them towards either dormancy or proliferation and development of overt bone metastases ... See full document

... vestigate dormancy. Niche cells are also incorporated in such models as they allow long term ...cancer cell dormancy in a bone mimetic envir- onment as breast cancer cells are known to ... See full document

... positioning stem cell niches ...mesenchymal cell fate to form local signaling centers that signal back to the epithelium to establish intestinal crypts as stem cell niches (Shyer et ... See full document

... Mechanobiologists have begun to elucidate mecha- nisms by which stem cells undergo mechano regulation, building on advances with non-stem cells. Several mechanotransductive proteins involved with producing ... See full document

... C-terminally tagged Zfh1 fusion proteins are functional Visualisation of expression patterns by GFP reporters, and temporally and spatially controlled expression using the Gal4 system, are key elements of the Drosophila ... See full document

... large size cells, cells inside bone marrow vessels, cells around footprints, and are scattered around. 442.[r] ... See full document

... If STAT activation in GSCs does not mediate their self-renewal, then what does it do? Testes that are globally depleted of stat lose both populations of stem cells, but CySCs can be rescued by restoring stat ... See full document

... marrow niche has predominantly been studied in vivo in genetic mouse models; by contrast, studies of HSC niches during embryonic development predominantly rely on ex vivo co- cultures of stromal and hematopoietic ... See full document

... the stem cell field is to improve health outcomes in ageing and ...of stem cell-based models of disease to the use of stem cells for cell-based ...adult cell types, it is ... See full document

... The cytoplasmic domains of both α6A and α6B con- tain serine, threonine, and tyrosine residues which could serve as potential phosphorylation sites. In fact, it has been shown that macrophage adhesion to laminin sub- ... See full document

... molecular, cell biological and developmental functions of this transcription factor have yet to be ...adult stem cell ...as cell type-specific and stage-specific knockdown of Lmx1a, we have ... See full document

... heart cell lines ...4. Cell based therapies: It is maybe the most vital potential use of human undeveloped ...particular cell sorts, offer the likelihood of a renewable wellspring of substitution ... See full document

... The Gene Ontology Consortium (GO Database, http://www.geneontology.org/) is a collaborative project which aims to provide vocabularies for gene annotations, gene products and sequences, with annotations being biological ... See full document

... study niche-stem cell ...the niche play a crucial role in regulating the behavior of GSCs (44-46, ...single niche has also been dominant in the ...the niche-stem ... See full document

... stem cell niche and meristematic zone, whereas the endocycle enhances cell ploidy levels associated with cell expansion at the elongation zone ...in cell cycle exit after mitosis ... See full document

... of stem cell-niche adhesion remain to be ...given stem cell type to interact with its ...purifying stem cells and for identifying surface molecules that could potentially mediate ... See full document

... A stem cell niche has been described as the specialized local microenvironment in which stem cells ...the niche has to be: (1) anatomically defined, (2) composed of specific ... See full document

... Strategies to engineer a stem cell niche. There are a variety of approaches to engineer and control individual niche components. These strategies can be multiplexed to produce hybrid devices ... See full document

... the stem cell ...how niche development is regulated in the Arabidopsis ...family, stem cell-specific expression of the signal peptide gene CLAVATA3 ( CLV3 ) is not maintained despite ... See full document