[PDF] Top 20 Drosophila Dok is required for embryonic dorsal closure
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Drosophila Dok is required for embryonic dorsal closure
... vector at the SmaI and BamHI sites to create pLexA-Shark encoding the LexA-Shark fusion protein bait. In addition, the cDNA encoding an activated Src-kinase domain was excised from the BTM116-Src vector (Keegan and ... See full document
11
Drosophila heart cell movement to the midline occurs through both cell autonomous migration and dorsal closure
... In Drosophila, heart cells are specified in bilateral rows in the lateral mesoderm (Poulson ...on dorsal closure, the movement of lateral ectodermal cells towards the dorsal midline thereby ... See full document
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Dynamic analysis of filopodial interactions during the zippering phase of Drosophila dorsal closure
... during embryonic development and also occurs during the process of wound healing (Martin and Parkhurst, ...human embryonic development gives rise to a spectrum of birth defects including spina bifida and ... See full document
6
Hedgehog and Wingless stabilize but do not induce cell fate during Drosophila dorsal embryonic epidermal patterning
... cell stripe depends on the En cells. As Hh is secreted by En cells (Tabata and Kornberg, 1994; Taylor et al., 1993), and is required for groove formation (Larsen et al., 2003), we investigated whether it controls ... See full document
9
Parallels between tissue repair and embryo morphogenesis
... There are a number of lessons for better wound healing that can be learned from the embryo. Undoubtedly, there are many parallels between those tissue movements that shape embryos during development and those that are ... See full document
14
Ion channels contribute to the regulation of cell sheet forces during Drosophila dorsal closure
... an increase in embryonic lethality and penetrance of morphogenetic defects (supplementary material Table S5). Of unhatched rpk/Df embryos (n=103 unhatched, 34.3% total observed), 78% fail to develop cuticle and ... See full document
10
PVF1/PVR signaling and apoptosis promotes the rotation and dorsal closure of the Drosophila male terminalia
... The Drosophila adult male terminalia originate from the genital ...right dorsal halves fuse at the dorsal ...three Drosophila homologues of the mammalian VEGF/PDGF growth factors, is ... See full document
8
The Fes/Fer non receptor tyrosine kinase cooperates with Src42A to regulate dorsal closure in Drosophila
... that Drosophila Fer localises to adherens junctions in the dorsal epidermis and regulates a major morphological event, dorsal ...in dorsal closure similar to those seen in dfer mutant ... See full document
11
Identification of Chromosomal Regions Involved in decapentaplegic Function in Drosophila
... the Drosophila decapentaplegic (dpp) locus is a well-characterized member of this ...factors required for TGF-b function in Drosophila by testing for genetic interactions between mutant alleles of ... See full document
13
The AF-6 Homolog Canoe Acts as a Rap1 Effector During Dorsal Closure of the Drosophila Embryo
... in Drosophila Rap1 cause and an active GTP-bound state, eliciting distinct down- severe morphogenetic abnormalities during embryonic stream responses in the active ...tion, dorsal closure, and ... See full document
12
Par3/Bazooka and phosphoinositides regulate actin protrusion formation during Drosophila dorsal closure and wound healing
... function. Closure of epithelial wounds is primarily driven by the cells bordering the wound, which undergo morphological changes following wounding, including the assembly of dynamic actin protrusions on the edge ... See full document
10
no poles encodes a predicted E3 ubiquitin ligase required for early embryonic development of Drosophila
... not required for inhibition (Lee et ...in Drosophila embryogenesis, probably by mediating its interactions with E2 components, as has been shown for other E3 ligases (Passmore and Barford, ...2004). ... See full document
11
The leading edge during dorsal closure as a model for epithelial plasticity: Pak is required for recruitment of the Scribble complex and septate junction formation
... in embryonic epithelial fusions and wound healing, and Scrib is required for cell migration in an in vitro wound healing assay (Dow et ...2004). Dorsal closure (DC) of the Drosophila ... See full document
10
The Protein 4.1, Ezrin, Radixin, Moesin (FERM) Domain of Drosophila Coracle, a Cytoplasmic Component of the Septate Junction, Provides Functions Essential for Embryonic Development and Imaginal Cell Proliferation
... is required to complete embryonic development, domain should complement alleles that affect only the whereas the C-terminal domain is required at a later other functional ...in dorsal ... See full document
10
Smurf Downregulates Echinoid in the Amnioserosa To Regulate Drosophila Dorsal Closure
... also contribute to the slow zippering. Together, our data suggest that after Ed transcription has ceased in the amnio- serosa, Smurf is required to downregulate the remaining Ed in the amnioserosa. In conclusion, ... See full document
8
Coordinated cell shape changes control epithelial movement in zebrafish and Drosophila
... anterior dorsal hole; 38% had closed but showed misalignment of segments; while 12% showed embryonic lethality without obvious defects during dorsal closure (n=48, ... See full document
11
Armadillo/β catenin dependent Wnt signalling is required for the polarisation of epidermal cells during dorsal closure in Drosophila
... Genetic screens, which are mainly based on surveying defects in the patterning of the dorsal epidermis, have identified a large number of genes required for DC. These can be grouped into two main ... See full document
11
Zygotic expression and activity of the Drosophila Toll gene, a gene required maternally for embryonic dorsal-ventral pattern formation.
... Ma- ternal expression of Toll is required for the produc- tion of the embryonic dorsal-ventral pattern, and zygotic expression of Toll in the embryo is required [r] ... See full document
11
Src family kinases are required for WNT5 signaling through the Derailed/RYK receptor in the Drosophila embryonic central nervous system
... Members of the RYK family of ‘dead’ or ‘fractured’ RTKs have been found in all metazoans examined (Halford and Stacker, 2001). The extracellular domain of RYK members contains a Wnt-binding WIF domain (Patthy, 2000). ... See full document
11
Genetic interaction between Lef1 and Alx4 is required for early embryonic development
... We demonstrated previously that the paired-like homeodomain- containing protein, Aristaless-like 4 (Alx4), could interact with Lef1 and synergize in the regulation of the N-CAM promoter (Boras and Hamel, 2002). ... See full document
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