[PDF] Top 20 Drug repurposing for the treatment of glioblastoma multiforme

... a drug network based on drug-drug ...of drug networks based on the similarity between compounds in perturbing gene expression signatures [26, ...following drug treatment is ... See full document

... Glioblastoma multiforme (GBM), the most frequent malignant and aggressive primary brain tumor, is characterized by genetically unstable heterogeneous cells, diffused growth pattern, microvascular ... See full document

... Glioblastoma multiforme (WHO grade IV astrocytoma) are tumours that arise from astrocytes: the star-shaped cells that make up the “glue-like or supportive tissue of the ...diagnosed glioblastoma ... See full document

... Abstract: Glioblastoma multiforme (GBM) is the most common malignant primary brain tumor in adults and carries the poorest ...and Drug Administration approval for the treatment of recurrent ... See full document

... Glioblastoma multiforme (GBM) is the most common and aggressive primary brain ...of treatment resistance; making their inhibition an appealing therapeutic ...combination treatment induced ... See full document

... Recurrent glioblastoma multiforme (GBM), insensitive against most therapeutic interventions, has low response and survival ...the treatment of brain tumors and is an attractive drug for ... See full document

... Abstract: Glioblastoma is the most common primary brain tumor with a relatively poor ...in treatment of this ...and Drug Administration (FDA) approval of bevacizumab in the setting of recurrent ...of ... See full document

... viral treatment than how cultured cells do, resulting in the observed discrepancy of spread between ...tumor treatment prior to the harvesting of the ...initial treatment primed the cells in the ... See full document

... Abstract: Glioblastoma multiforme (GBM) remains one of the most malignant primary central nervous system tumors. Personalized therapeutic approaches have not become standard of care for GBM, but science is ... See full document

... FC100 drug, the perturbation of the cellular system U-87 MG fails to produce a specific cytostatic or cytotoxic effect, irrespective of the concentration ...of treatment when compared to 48 and 72 hours ... See full document

... Activation of the complement system contributes to a wide variety of CNS diseases including Alzheimer disease, CNS inflammation, traumatic brain injury and tumors [6, 55]. The cross-link between inflammation and cancer ... See full document

... Abstract: Glioblastoma multiforme (GBM) remains one of the most devastating tumors, and patients have a median survival of 15 months despite aggressive local and systemic therapy, including maximal surgical ... See full document

... Watanabe and colleagues reported that IDH1 mutations always preceded acquisition of TP53 mutations (in astrocytomas) and loss of 1p/19q (in oligodendrogliomas) [51]. These results suggest that IDH mutations are early ... See full document

... reported that primary malignant CNS tumors encompass 2.3% of all primary malignant tumors. Astrocytoma and glioblastoma together form 60.4% of the primary malignant registered brain tumors (6). The more the age, ... See full document

... diagnosed Glioblastoma Mulltiforme ...same treatment with more than 6 cycles of adjuvant chemotherapy extended as long as the pa- tient in good performance, with no unacceptable toxicity, no signs of ... See full document

... (25). Glioblastoma is the most common of all lethal brain ...as glioblastoma stem cells (GSCs) and they have the p o t e n t i a l t o d i ff e r e n t a t e i n t o n e u r o n s , oligodendrocytes and ... See full document

... cellular astrocytic neoplasm with extensive areas of necrosis and endothelial proliferation. Tumor cells showed marked nuclear pleomorphism with bizarre giant cells and extensive mitosis. Two weeks later, the patient ... See full document

... combined treatment of DCA and phenformin is expected to inhibit lactic acidosis in response to treatment with ...combined treatment of phenformin and DCA resulted in synergistic cytotoxic effects ... See full document

... Introduction: Glioblastoma multiforme (GbM), the most aggressive malignant primary brain tumor, is uncommon in children accounting for only 3% of primary pediatric brain ...conclusion: Glioblastoma ... See full document

... GBM: glioblastoma multiforme; GFAP: glial fibrillary acidic protein; GSCs: glioblastoma stem cells; GST-π: glutathione S-transferase π; H&E: hematoxylin and eosin; IB: immunoblotting; IC50: the ... See full document