[PDF] Top 20 Drugs in induction and treatment of idiopathic inflammatory myopathies

... Conflicting results on the use of high dose intravenous immunoglobulins (IVIg) in patients with IIM has been reported in the literature. A double-blind, placebo-con- trolled, crossover trial in 15 patients diagnosed with ... See full document

... Treatment of dyslipidaemia in patients with IIM is complex. Statins can prevent cardiovascular disease in the general population. In rare cases, statins can be the main cause of disease, that is, statin-associated ... See full document

... immunosuppressive drugs, which is why the role of T lymphocytes in disease mechanisms is more questionable in this form of ...immunosuppressive drugs given to patients with ...these drugs could ... See full document

... While the exact pathogenesis of CAM remains unclear, a paraneoplastic nature was assumed in the ma- jority of these patients because cancer diagnosis and myositis onset seemed to temporally coincide. Addition- ally, ... See full document

... and treatment initi- ...of treatment (range 145–150), due to ceiling ...after treatment initiation range 50–300 IU/L), which indi- cates reducing disease activity, and increase in SF-36 scores ... See full document

... (42.1%), anti Jo-1 (34.2%), anti-Mi-2 (10.5%), and no cases of anti-OJ, anti-EJ, anti-PL-7 or anti-PL-12 autoantibodies. All 38 patients were in concomitant use of at least two immunosuppressive / immunomodulatory ... See full document

... a treatment of resistant- DM that may be also used in other resistant-IIMs; iv) physical therapy and sun protection (in DM patients) are part of the treatment; v) tumour screening for patients with DM ... See full document

... glucocorticoid treatment varies signifi cantly; furthermore, the degrees of infl am- matory infi ltration and muscle function are dissociated, suggesting a role for other mechanisms in muscle dys- func tion in these ... See full document

... There are currently no disease-specific treatments for IIM; instead anti-inflammatory, immunosuppressive and immunodulatory treatments are borrowed from other rheumatic diseases. Furthermore, despite ... See full document

... Clinical and laboratory features of DM/PM patients All patients and NC were matched for age, sex, and eth- nicity (Table 1). DM patients have higher incidence of interstitial lung disease (ILD) than PM patients and PM ... See full document

... additional treatment or alteration, as we did when Calc1 and Calc2 blocks were imaged first with qBSE, subsequently mapped with FTIR-RM and SEM/SDD-EDS, and then scanned with μCT that supplied the internal ... See full document

... Abstract Idiopathic inflammatory myopathies (IIM) are a group of diseases characterized by inflammation of the skeletal ...some drugs (statins), muscular dystrophy, muscular trauma or in case ... See full document

... arms of the immune system. The pathogen may also lead to disease via epitope spreading. Patients with myositis with lung disease and anti-Jo-1 positivity were reported to be associated with type I interferon (IFN) ... See full document

... Abstract: This study aimed to determine the expression pattern of the adenosine receptor (AR) subtypes A 2A , A 2B , and A 3 in human idiopathic inflammatory myopathies (IIMs). A total of 27 patients ... See full document

... In conclusion, in this study, we found the presence of ILD-PH in the majority (55%) of the selected patients with IIM and PH. Surprisingly, a relevant group (33%) of patients with IIM suffered from non-ILD-PH, which ... See full document

... separated from patients with PM in the subclassification tree. Studies including more patients with IMNM could enable revising these criteria in the future to separate Figure 2 Classification tree for subgroups of ... See full document

... a link between calcium deposition in tissues, the calcinosis characteristic of JDM, and the development of neutrophil activation and NETs in muscle tissue (15). This may be an additional mechanism that induces NET ... See full document

... to treatment and prognosis, and refer less frequently for surgical ...the idiopathic setting, with subtle differences noted including fewer fibroblastic foci, smaller honeycombing spaces, higher germinal ... See full document

... regeneration and repair [25]. Accordingly, the role of resis- tin in the pathology of muscle tissue in myositis is under- pinned by its association with parameters of disease activity in the group of patients with ... See full document

... Idiopathic inflammatory myopathies represent a heterogeneous group of autoimmune diseases with systemic involvement. Even though numerous specific autoantibodies have been recognized, they have not ... See full document