[PDF] Top 20 Dysregulation of the RANKL/RANK/OPG axis in thalassemia intermedia patients

... TI patients attending the Thalassemic unit of Princess Rahma hos- pital in Irbid, ...Diabetic patients, patients with thyroid or liver disease, patients taking steroids, anticonvulsant ... See full document

... ing OPG and RANKL circulating levels in T1D patients (Table 3) ...lower OPG levels compared to controls, is in agreement with several studies, in which no microvascular complications of T1D ... See full document

... the OPG/RANK/RANKL role in pathogenesis of vascular calcifications and ...in patients with chronic kidney dis- ease (CKD), have brought many conflicting ...this axis may be crucial for ... See full document

... of OPG with BMD measurement, which high- lights the potential link between nephrolithiasis and reduced bone mass, but due to the cross-sectional na- ture of our study cautious the causal assumption be- tween them; ... See full document

... the RANK/RANKL/OPG system was confirmed both at mRNA and protein levels in the rat IVD, including the in ...the RANK/RANKL/OPG sys- tem by AF, NP and CEP ...the ... See full document

... the RANK/RANKL/OPG system was confirmed both at mRNA and protein levels in the rat IVD, including the in ...the RANK/RANKL/OPG sys- tem by AF, NP and CEP ...the ... See full document

... The OPG/RANK/RANKL system is an important regulator of bone metabolism, and participates in the development of post-menopausal ...the OPG/RANK/RANKL pathway is involved in the ... See full document

... the RANKL/RANK/OPG system represents the most important advance in osteoclast biology in the past ...of RANKL, OPG, or both, which are expressed by osteoblasts and stromal cells or ... See full document

... VDR, RANK, RANKL, OPG and osteocalcin (OC) were determined in total lysates from tibias by western blot ...USA); RANK (1:400; Santa Cruz Biotechnology, USA); RANKL (1:250; Santa Cruz ... See full document

... The RANKL inhibitor denosumab was irst approved in 2010 and is now indicated for the prevention of skeletal- related events (SREs) in adults with advanced malignancies involving bone ...in patients with ... See full document

... on thalassemia patients that are due to disorder during rest time of the ventricle caused by iron deposits (12, ...asymptomatic patients have also been mentioned in Vaccari and Bosie studies, the ... See full document

... of RANKL/RANK/OPG pathway in exercise and physical performance as one of the most important remodeling systems is not considered comprehensive in previous ... See full document

... PTH-rP, RANK Ligand and MIP-1alpha have been involved in mediating the enhanced osteoclast formation and bone destruction in patients with ...the RANKL/RANK/OPG system has implicated ... See full document

... The RANKL-OPG system in clinical periodontology Belibasakis, Georgios N ; Bostanci, Nagihan Abstract: BACKGROUND AND OBJECTIVES: The receptor activator of NF-฀B ligand-osteoprotegerin ... See full document

... evolution RANKL/RANK/OPG system - originally required only for bone remodeling - shifted to calcium-related func- tions even in mammary gland ...that RANKL is a key regulator of mammary ... See full document

... 50 OPG and RANKL has not been completely understood, it is important to remember that systemic RANKL and OPG levels may reflect a systemic inflammatory process that is not related to the ... See full document

... heritable. RANKL/RANK/OPG signaling pathway is essential for mammary gland development, which is also found associated with post-menopausal and hormone-related ...the ... See full document

... lates OPG expression and downregulates RANKL ...of OPG and promote osteoblastic differentiation via the Wnt/ β -catenin signaling ...the RANK/RANKL/OPG signaling ... See full document

... (RANK)/ RANK ligand (RANKL)/osteoprotegerin cytokine system has been well implicated in several physiological and pathological processes including bone metabolism, mammary gland devel- opment, ... See full document

... the RANK/RANKL/OPG system would be in- cluded in the complex molecular mechanism of human IVD degeneration by interactions with the proinflammatory cyto- kines ...aberrant RANKL signaling in ... See full document