Top PDF Early Events in Kaposi's Sarcoma-Associated Herpesvirus Infection of Target Cells
Early Events in Kaposi's Sarcoma-Associated Herpesvirus Infection of Target Cells
... the early events of KSHV infection of target cells that remain to be ...different target cells and modes of entry remain incompletely ...KSHV infection of ...
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Focal Adhesion Kinase Is Critical for Entry of Kaposi's Sarcoma-Associated Herpesvirus into Target Cells
... the target cell, certain reasonable scenarios can be hypothesized ...of early events of KSHV infection of target cells, KSHV-induced signal pathways, and their role in ...the ...
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Limited Transmission of Kaposi’s Sarcoma-Associated Herpesvirus in Cultured Cells
... 293 cells is ex- tremely inefficient compared to that generated by induction of BCBL-1 cells, with variable RNA levels hovering around the detection threshold of the cDNA hybridization assay, and that (ii) ...
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RhoA-GTPase Facilitates Entry of Kaposi's Sarcoma-Associated Herpesvirus into Adherent Target Cells in a Src-Dependent Manner
... lation early during infection of adherent target cells, such as HMVEC-d, HFF, and FAK ⫹/⫹ mouse embryonic fibroblast Du17 cells (4, 36, ...Du3 cells demonstrated that FAK is ...
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Activation of Plasmacytoid Dendritic Cells by Kaposi's Sarcoma-Associated Herpesvirus
... Kaposi’s sarcoma-associated herpesvirus (KSHV) is the eti- ological agent of Kaposi’s sarcoma, primary effusion lym- phoma (PEL), and multicentric Castleman’s disease (MCD) (8, ...human ...
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Host Range of Kaposi's Sarcoma-Associated Herpesvirus in Cultured Cells
... influential early studies (2, 23) looked for evi- dence of KSHV propagation by serial passage in the absence of phorbols or other inducing agents, much as one might do for herpes simplex virus type 1 or ...many ...
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Reactive Oxygen Species Are Induced by Kaposi's Sarcoma-Associated Herpesvirus Early during Primary Infection of Endothelial Cells To Promote Virus Entry
... These cells were then infected with KSHV for 2 h, washed, and maintained in 1 mM NAC for 24 h; then RNA was extracted and analyzed by real-time RT-PCR using ORF 73, ORF 50, and K8 primers (3, ...NAC-treated ...
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Identification of the Immediate-Early Transcripts of Kaposi’s Sarcoma-Associated Herpesvirus
... BCBL-1 cells to the toxicity of cycloheximide made it impossible to examine the transcription of these mRNAs in the absence of de novo protein synthesis in this cell ...BCBL-1 cells in the same stage as ...
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De Novo Infection and Serial Transmission of Kaposi's Sarcoma-Associated Herpesvirus in Cultured Endothelial Cells
... of cells undergoing lytic repli- cation compared to untreated cells (20 to 30% versus ...rounded-up cells, often containing multinucleated cells piling up in discrete foci, were observed ...
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CRISPR Cas9 Screening of Kaposi’s Sarcoma Associated Herpesvirus Transformed Cells Identifies XPO1 as a Vulnerable Target of Cancer Cells
... cancer cells is driven by deregulated on- cogenes or tumor suppressors, among which the cancer-vulnerable genes are attrac- tive therapeutic ...Kaposi’s sarcoma-associated herpesvirus (KSHV)- ...
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Kaposi Sarcoma Herpesvirus Induces HO 1 during De Novo Infection of Endothelial Cells via Viral miRNA Dependent and Independent Mechanisms
... plant cells, as well as by the viruses that infect them (19, ...to target the mRNA encoding the HO-1 transcriptional repressor BACH1 (22, ...KSHV infection, which suggests that miR-K12-11 functions ...
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ZIC2 Is Essential for Maintenance of Latency and Is a Target of an Immediate Early Protein during Kaposi's Sarcoma-Associated Herpesvirus Lytic Reactivation
... 293T cells were cotransfected with a fixed amount of HA-tagged ZIC2 (1 g) and increasing amounts of FLAG-K-Rta (0, ...293T cells were transfected with increasing amounts of HA-K-Rta (0, 1, 2, and 3 ...
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IKKγ-Mimetic Peptides Block the Resistance to Apoptosis Associated with Kaposi's Sarcoma-Associated Herpesvirus Infection
... Jurkat cells was only moderately reduced compared to that of cells null for ks-vFLIP, which were severely compromised ...Jurkat cells. Viability assays were conducted with Jurkat cells treated ...
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Upregulation of the TLR3 Pathway by Kaposi's Sarcoma-Associated Herpesvirus during Primary Infection
... to infection by ...upon infection of THP-1 and CD14-positive primary human ...virus infection of lung epithelial ...enter cells through endocytosis (6), the virus may encounter TLR3 in the ...
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Use of a Multiantigen Detection Algorithm for Diagnosis of Kaposi's Sarcoma Associated Herpesvirus Infection
... the cells at a multiplicity of infection equal to 1 for 45 min at room ...Infected cells were brought back up to full volume and incubated for 3 days at 27°C prior to ...harvest. Cells were ...
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Establishment and Maintenance of Kaposi's Sarcoma-Associated Herpesvirus Latency in B Cells
... (IE), early, and late gene ...of cells has been induced with overexpression of open reading frame 50 (ORF 50 or RTA), a KSHV gene that is both necessary and sufficient to activate lytic replication (35, ...
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Transcriptome Analysis of Kaposi's Sarcoma-Associated Herpesvirus during De Novo Primary Infection of Human B and Endothelial Cells
... primary infection of human PBMCs, CD14 ⴙ , and TIVE ...primary infection of B and endothelial cells (natural target cells of KSHV), purified virions were used for the de novo ...
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Kaposi's Sarcoma-Associated Herpesvirus MicroRNAs Target GADD45B To Protect Infected Cells from Cell Cycle Arrest and Apoptosis
... Kaposi’s sarcoma is one of the most common malignancies in HIV- infected ...Kaposi’s sarcoma-associated herpes- virus (KSHV; HHV8), expresses multiple microRNAs (miRNAs), but the targets and ...
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Original Article Kaposi’s sarcoma-associated herpesvirus infection induces overexpression of LYN in Kaposi’s sarcoma
... Kaposi’s sarcoma-associated herpesvirus (KSHV) is an important pathogen for Kaposi’s sarcoma (KS), a multiple ...Yamaguchi sarcoma viral related on- cogene homolog (lyn) gene in ...
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Ets-1 Is Required for the Activation of VEGFR3 during Latent Kaposi's Sarcoma-Associated Herpesvirus Infection of Endothelial Cells
... spindle cells express high levels of Ang2, a gene shown to be upregulated by KSHV infection of macrovas- cular endothelial cells in an Ets-1-dependent fashion ...spindle cells), while in ...
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