[PDF] Top 20 The Effect of Decitabine Combined with Arsenic Trioxide on DAPK Gene and HL 60 Cell Proliferation and Apoptosis
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The Effect of Decitabine Combined with Arsenic Trioxide on DAPK Gene and HL 60 Cell Proliferation and Apoptosis
... [15]. DAPK can participate in IFN-γ, TNF-α, P53, and other cell-mediated apoptotic signaling pathway ...[16]-[18]. DAPK is characterized by a conserved Ca 2+ /Calmodulin (CaM) regula- tory domain, a ... See full document
9
The effect of nilotinib plus arsenic trioxide on the proliferation and differentiation of primary leukemic cells from patients with chronic myoloid leukemia in blast crisis
... Hence, combined drug applications may help overcome the drug resistance of nilotinib therapy ...agent arsenic trioxide (ATO) has been used for the treatment of patients with acute pro- myelocytic ... See full document
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Basic Mechanisms of Arsenic Trioxide (ATO)-Induced Apoptosis in Human Leukemia (HL-60) Cells
... APL cell lines have shown that ATO treatment activates caspases [16], down-regulates Bcl-2 protein and up-regulates of p53 expression ...response, cell cycle progression, pro- grammed cell death, and ... See full document
9
Arsenic trioxide induces oxidative stress, DNA damage, and mitochondrial pathway of apoptosis in human leukemia (HL-60) cells
... and cell death in a variety of cells including acute promyelocyte leukemia (APL), acute myeloid leukemia and chronic myeloid leukemia as well as solid tumor cells in vitro [35], but leukemia cells appear to be ... See full document
12
<p>Effect and Mechanism of miR-26a-5p on Proliferation and Apoptosis of Hepatocellular Carcinoma Cells</p>
... metastasis of cancer cells in various tumors including hepatoma. 21 Our results showed that HMGA2 was highly expressed in HCC tissues and cells, and the expression levels of HMGA2 and miR-26a-5p were negatively cor- ... See full document
10
Effects of oridonin nanosuspension on cell proliferation and apoptosis of human prostatic carcinoma PC-3 cell line
... early apoptosis rate of PC-3 cells increased with ORI concentration, reaching ...the effect of nanosuspension in inducing apoptosis in PC-3 cells, PC-3 cells were treated with ORI nanosuspension at ... See full document
8
Mitochondrial and endoplasmic reticulum stress pathways cooperate in zearalenone-induced apoptosis of human leukemic cells
... and cell death [50]. CRT was translocated to the cell membrane of human leukemic cells treated with ZEA (Figure ...of HL-60 treated cells showed increased expres- sion of GRP78, ERp29 and CRT ... See full document
16
The combination astemizole–gefitinib as a potential therapy for human lung cancer
... The drug treatment did not modify Eag1 mRNA levels or protein expression in NCI-H1975 cells (data not shown). However, while the drugs alone did not affect Eag1 mRNA expression in A549 cells, the drug combination ... See full document
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Original Article JARID1B deletion induced apoptosis in Jeko-1 and HL-60 cell lines
... mantle cell lymphoma (MCL) and acute ...and cell apoptosis and cell proliferation were detected by flow cytometry and MTT [3-(4,5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium ... See full document
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Consolidation therapy of arsenic trioxide alternated with chemotherapy achieves remarkable efficacy in newly diagnosed acute promyelocytic leukemia
... (ATRA) combined with daunorubicin and ATRA combined with arsenic trioxide (ATO) therapies are considered the standard induction therapy regimens for adult patients newly diagnosed with acute ... See full document
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The hypomethylating agent decitabine prior to chemotherapy improves the therapy efficacy in refractory/relapsed acute myeloid leukemia patients
... from decitabine treatment with a good toleration [4, ...single decitabine may have limited anti- leukemia effect in relapsed/refractory AML, the results from retrospective studies suggested that it ... See full document
11
Arsenic trioxide inhibits the proliferation of myeloma cell line through notch signaling pathway
... Notch signaling influences multiple processes that govern normal morphogenesis, apoptosis, and cellular proliferation. This signaling is initiated by binding of a Notch ligand to the extracellular domain of ... See full document
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Original Article Targeting miR-9 suppresses proliferation and induces apoptosis of HL-60 cells by PUMA upregulation in vitro
... KR. Gene ex- pression in ovarian cancer reflects both mor- phology and biological behavior, distinguishing clear cell from other poor-prognosis ovarian ... See full document
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Synergistic Effects of Arsenic Trioxide and Radiation: Triggering the Intrinsic Pathway of Apoptosis
... times. Cell viability rate was calculated as the percentage of MTT absorption as shown in the following equation: % survival=(mean experimental absorbance)/(mean control ... See full document
8
Arsenic trioxide inhibits viability and induces apoptosis through reactivating the Wnt inhibitor secreted frizzled related protein-1 in prostate cancer cells
... the expression of phospho-GSK-3 β increased, whereas the expression of β -catenin decreased in LNCaP and PC3 cells treated with As 2 O 3 in a dose-dependent manner, and the expression of GSK-3 β was not affected by As 2 ... See full document
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BERBERINE, COPTIDIS RHIZOMA AND DIOSPYRIN AS NOVEL ANTINEOPLASTIC AGENTS: A REVIEW ON TRADITIONAL USE AND BIOMEDICAL INVESTIGATIONS
... induces apoptosis via positive or negative regulation of various cytokines functioned in cellular ...of apoptosis as one of Bax ...berberine-induced apoptosis in human cervical cancer Ca Ski cells, ... See full document
11
Dose Dependent Biological Effects of Idarubicin in HL-60 Cells: Alterations of the Cell-Cycle and Apoptosis
... inhibit proliferation of the cells and induce changes in cell ...of cell-cycle, af- ter 24 hours we observed arrest in G 2 ...significant apoptosis and the cells did not proliferate during 72 ... See full document
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Arsenic sulfide, the main component of realgar, a traditional Chinese medicine, induces apoptosis of gastric cancer cells in vitro and in vivo
... Detection of apoptosis was performed using a TdT-medi- ated dUTP nick end labeling (TUNEL) assay kit, which was purchased from R&D Systems, Inc. (Minneapolis, MN, USA). Tissue slides were treated with ... See full document
14
Vitamin D3 potentiates the antitumorigenic effects of arsenic trioxide in human leukemia (HL-60) cells
... apoptotic mechanism as evidenced by DNA laddering, the hallmark of apoptotic cells. The apoptotic DNA Ladder kit from Roche Molecular Biochemicals (Indianapolis, IN) was used as directed. A sample volume of 800 μL ... See full document
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IMMUNE SYSTEM STATE IN CHRONIC CHOLECYSTITIS AND METABOLIC SYNDROME PATIENTS
... sality combined with the historically accumulated ex- perience of the form elements proportioning, give a new impetus to the design art development and, as a necessary condition, the integration of design solu- ... See full document
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