[PDF] Top 20 Effect of population stratification on the identification of significant single nucleotide polymorphisms in genome wide association studies
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Effect of population stratification on the identification of significant single nucleotide polymorphisms in genome wide association studies
... the stratification score approach will tend to lose power relative to a pooled (unadjusted) analysis when there is no ...the stratification score ...residual stratification in the primary analyses ... See full document
5
Two stage study designs combining genome wide association studies, tag single nucleotide polymorphisms, and exome sequencing: accuracy of genetic effect estimates
... the effect of the rare SNPs (correlation with r i / n i was r > ...detect effect above significance level a for at least one of a = ...genetic effect estimate was inflated by ... See full document
7
Applicability of Precision Medicine Approaches to Managing Hypertension in Rural Populations
... Genome-wide association studies (GWAS) identified associations between specific genetic loci, 87.. mapped by the presence of “single nucleotide polymorphisms” (SNPs) that represent gene[r] ... See full document
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Genome wide association studies using single nucleotide polymorphisms versus haplotypes: an empirical comparison with data from the North American Rheumatoid Arthritis Consortium
... haplotype-based association testing using a sliding window of fixed physical or genetic size would be an alternative ...the genome suggests that methods that use this structure (such as those applied in ... See full document
6
Genetic associations of the response to inhaled corticosteroids in asthma: a systematic review
... is wide variability in the response to inhaled corticosteroids (ICS) in ...pharmacogenomic studies on ICS and discuss the latest insight into the potential functional role of identified genetic ...seven ... See full document
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Rapid multiplex high resolution melting method to analyze inflammatory related SNPs in preterm birth
... like genome-wide association studies (GWAS) yield informa- tion on millions of single nucleotide polymorphisms (SNPs) distributed across the human genome, to inden- ... See full document
8
Qiu-Yue Zhang 1,* , Hui-Fu Wang 1,* , Zhan-Jie Zheng 2, Ling-Li Kong2 , Meng-Shan Tan 1, Chen-Chen Tan1 , Wei Zhang 3, Zi-Xuan Wang1 , Lin Tan 4, Jin-Tai Yu1 and Lan Tan 1
... activating genome instability ...The single nucleotide polymorphisms (SNP), rs17125944 in the FERMT2 gene on chromosome ...reached genome-wide significance in the combined ... See full document
7
Genome-wide identification and analysis of miRNA-related single nucleotide polymorphisms (SNPs) in rice
... a genome-wide scan of miRNA-related SNPs, and analyzed their effects on the stability of miRNAs structure and the alteration of target spectrum in ... See full document
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miRNA-dependent target regulation: functional characterization of single-nucleotide polymorphisms identified in genome-wide association studies of Alzheimer’s disease
... between studies [32, ...independent studies had found that levels of miR-1185-1-3p were abnormally low in the AD brain (compared with controls) [35, 38] (Additional file 3: Table ... See full document
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Marker selection for whole genome association studies with two stage designs using dense single nucleotide polymorphisms
... strong effect of the HLA-DRB1 locus, all three methods have returned more than one sig- nificant SNPs that are close to the locus, even with as few as 100 individuals (Table ...high association with causal ... See full document
5
Genotyping of the Alzheimer’s disease Genome Wide Association Study index single nucleotide polymorphisms in the Brains for Dementia research cohort
... The single exception was for rs35349669 (INPP5D), where opposing alleles were found in the minor frequencies, despite the T-allele minor frequency in the general population being approximately 21%, in the ... See full document
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Original Article Association of single nucleotide polymorphisms in ADAM12 gene with susceptibility to knee osteoarthritis: a case-control study in a Chinese Han population
... Several genome-wide association studies (GWAS) based on large- sample population have demonstrated single nucleotide polymorphisms (SNPs) in various genes were ... See full document
6
Genomic Approaches to Understanding Variable Expressivity in Alagille Syndrome and Genetic Susceptibility to Biliary Atresia
... including genome-wide gene expression analysis, genome-wide association (GWA) studies of single nucleotide polymorphisms (SNPs) and copy number variation ... See full document
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Common genetic variants associated with disease from genome wide association studies are mutually exclusive in prostate cancer and rheumatoid arthritis
... twin studies suggest that 42% of the risk could be due to genetic factors ...to genome-wide association studies (GWAS), which have so far reported 49 single nucleotide ... See full document
9
Lack of association of two common polymorphisms on 9p21 with risk of coronary heart disease and myocardial infarction; results from a prospective cohort study
... detect effect sizes as shown in the published ...lowest effect: 1.18, shown in ARIC study [2]) and 1.23 for MI (the lowest effect: ...Iceland population A) ...former studies may be ... See full document
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Genome-Wide Association Study of Late-Onset Myasthenia Gravis: Confirmation of TNFRSF11A and Identification of ZBTB10 and Three Distinct HLA Associations
... an association with TNFRSF11A (alias RANK) in the LOMG subset defined by age of onset >40 years ...using population substructure matching of publicly avail- able control genotypes, and imputation methods ... See full document
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An association study between USP34 and polycystic ovary syndrome
... Some limitations of the present replication study should be mentioned. First, the sample size of this rep- lication study was relatively small (rs17008940, OR = 1.010; rs17008097, OR = 1.007) and this replication study ... See full document
5
Deep targeted sequencing of 12 breast cancer susceptibility regions in 4611 women across four different ethnicities
... a single-stranded RNA hybridization bait for fishing targets of interest out of a “pond” of randomly sheared, adaptor-ligated, and polymer- ase chain reaction-amplified ...remaining nucleotide is the tar- ... See full document
13
Genome-wide DNA methylation profiling in the superior temporal gyrus reveals epigenetic signatures associated with Alzheimer’s disease
... the association of our DMRs with functional genome-wide datasets generated in non- diseased brain tissue/cell ...found significant enrichments for hyper DMRs in poised promoters (corrected P = ... See full document
14
Genome-wide analysis of genetic predisposition to Alzheimer’s disease and related sex disparities
... European population haplotypes; fastBAT: Fast Set-Based Association Test; FDR: False discovery rate; FHS: Framingham Heart Study; GCTA: Genome-wide Complex Trait Analysis; GLMM: Generalized ... See full document
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