[PDF] Top 20 Effectiveness of trastuzumab as adjuvant therapy in patients with early stage breast cancer: A systematic review and meta-analysis

... Breast cancer (BC) is the most common type of cancer worldwide and is one of the leading causes of death in can- cer ...of cancer are diagnosed in the world and more than 400 000 people are ... See full document

... of cancer arise, as the FDA and National Cancer Institute both define it [43], whereas other institutions such as Cancer Research UK report DFS as the proportion of patients who are alive and ... See full document

... of patients with potentially resectable disease over the past two decades, even after the effort of adjuvant therapy (AT) ...the early recurrence caused by micrometastases that were not ... See full document

... for patients with small tumors (< 2 cm) show a slightly greater OS advantage was provided by H/anthra- cycline-containing chemotherapy compared with H/ non-anthracycline-containing ...Central Cancer ... See full document

... The trastuzumab- based therapy applied in different studies was single trastuzumab therapy or in combination with traditional chemotherapy (mainly ...of patients stratified by ... See full document

... this analysis. First, we referred to the Vietnamese utility data for breast can- cer in the absence of such data in the ...Vietnamese patients on the valuation of health states because of nu- merous ... See full document

... The patients were stratified into two groups: complete resec- tions with or without nodal involvement and, palliative resections for positive margins or metastatic ...resected early (T1b) carcinomas and did ... See full document

... this review. It was not possible to conduct a meta-analysis due to significant het- erogeneity between ...because patients know that they are being ... See full document

... the meta-analysis conducted by Valachis et ...current meta-analysis included data from a 60-month follow-up period, while the Valachis study an- alyzed data from a 54-month follow-up ... See full document

... a meta-analysis based on previous studies and not on patient ...and early breast cancer studies included in present study, and patients with metastatic breast ... See full document

... this review: Ikeoluwapo Ajayi, Dami Olorunda, Vera Braun, Frank Mockenhaupt, Harry Tagbor, Matthew Cairns, Brian Greenwood, Dominic Mosha, Mats Wahlgren, Fatuma Namusoke, Linda Kalilani-Phiri, ... See full document

... triple-negative breast cancer, and almost 60% had poorly differentiated ...of patients received chemotherapy in addition to endocrine therapy, 10% of those with HR-positive breast ... See full document

... that cancer cells have aberrant cell cycle machin- ery that aids them to divide and proliferate ...these cancer cells might provide a way to overcome the resistance in cancer ... See full document

... 152 patients who underwent conserva- tive surgery for early-stage breast cancer (pTis, pT1-2, pN0-1) and who adhered, between October 2004 and December 2010, to our adjuvant ... See full document

... the effectiveness of CBT in improving glycaemic control over the longer ...the stage of diabetes in which delivery of CBT is most ...the effectiveness of CBT in preventing poor glycaemic control ... See full document

... BC patients underwent partial or total mastectomy with axillary lymphadenectomy, with or without radiotherapy, chemotherapy and/or hormone therapy at the National Cancer Institute (INCA, Rio de ... See full document

... with breast cancer following a ...with breast cancer for whom a VTE may exert a particularly poor prognostic effect, and for whom treatment strategies could therefore be ...with breast ... See full document

... of patients, mean age, percentage of male), definition of “early” and “late” RRT, main characteristics at the time of RRT initiation (modality, creatinine, urine output, acute physiology and chronic health ... See full document

... PIK3CA mutation in HER2-positive tumors, leading to PI3K pathway irregulation, has been shown to be important in developing resistance to trastuzumab [24]. PIK3CA mutation has been reported in approximately 20% to ... See full document

... traditional therapy (radiotherapy or surgery alone) in some randomized controlled trials (RCTs), especially, in patients with intermediate- or high-risk PCa ... See full document